Patent US4681763A successfully refreshed from Google Patents.
US4681763A
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Composition for stimulating bone growth
Assignee: Rutgers Health
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Filing: 1985-06-11
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Granted: 1987-07-21
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Expires: 2005-06-11
Abstract
Abstract There is disclosed a method of recovering a material active in the formation of new bone and cartilage from demineralized bone extract and the composition of said material on a pliable physiologically acceptable support.
Inventors
- 👤 Mark A. Nathanson
- 👤 A. H. Reddi
- 👤 T. K. Sampath
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:52
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/32
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
46 words
A composition for implantation into animals to stimulate new bone growth comprising: a material capable of stimulating formation of new bone and cartilage in vivo derived from demineralized bone by use of aqueous guanidine hydrochloride, said material deposited by precipitation onto a pliable physiologically acceptable support.
Claim 2
Dependent Claim
46 words
A composition for implantation into animals to stimulate new bone growth comprising: a material capable of stimulating formation of new bone and cartilage in vivo derived from demineralized bone by use of aqueous guanidine hydrochloride, said material deposited by precipitation onto a pliable physiologically acceptable support.
Claim 3
Dependent Claim
14 words
The composition of claim 1, wherein the pliable physiologically acceptable support comprises collagen gel.
Claim 4
Independent Claim
68 words
A method of recovering a material capable of stimulating cartilage in vivo derived from demineralized bone by use of aqueous guanidine hdrochloride comprising: (a) applying a solution of said material in aqueous guanidine hydrochloride to a pliable physiologically acceptable support; (b) precipitating said material from the solution of aqueous guanidine hydrochloride onto the support by the addition of a precipitating agent; and (c) removing the volatile alcohol solvent.
Claim 5
Independent Claim
68 words
A method of recovering a material capable of stimulating cartilage in vivo derived from demineralized bone by use of aqueous guanidine hdrochloride comprising: (a) applying a solution of said material in aqueous guanidine hydrochloride to a pliable physiologically acceptable support; (b) precipitating said material from the solution of aqueous guanidine hydrochloride onto the support by the addition of a precipitating agent; and (c) removing the volatile alcohol solvent.
Claim 6
Dependent Claim
14 words
The method of claim 3, wherein the precipitating agent is a volatile alcohol solvent.
Claim 7
Dependent Claim
15 words
The method of claim 3, wherein the temperature of the precipitating agent is -10° C.
Claim 8
Dependent Claim
14 words
The method of claim 3, wherein the concentration of the precipitating agent is 85%.
Claim 9
Independent Claim
62 words
A method of preparing an implant to induce new bone growth which comprises (a) providing a solution of a material capable of stimulating formation of new bone and cartilage in vivo derived from demineralized bone by use of aqueous guanidine hydrochloride; (b) applying said solution to a pliable physiologically acceptable support; and (c) percipitating said material from said solution onto said support.
Claim 10
Independent Claim
62 words
A method of preparing an implant to induce new bone growth which comprises (a) providing a solution of a material capable of stimulating formation of new bone and cartilage in vivo derived from demineralized bone by use of aqueous guanidine hydrochloride; (b) applying said solution to a pliable physiologically acceptable support; and (c) percipitating said material from said solution onto said support.
Claim 11
Dependent Claim
15 words
The method of claim 7 wherein the pliable physiologically acceptable support is a collagen gel.
Claim 12
Dependent Claim
20 words
The method of claim 7 wherein the precipitation of said material is caused by the addition of an alcohol solvent.
Claim 13
Dependent Claim
13 words
The method of claim 9 wherein the alcohol solvent is ethanol or isopropanol.
Claim 14
Independent Claim
62 words
A method of stimulating formation of new bone and cartilage in vivo which comprises implanting in a patient in need of such stimulation therapy an implant which comprises a material capable of stimulating formation of new bone and cartilage in vivo derived from demineralized bone by use of aqueous guanidine hydrochloride said material deposited by precipitation onto a pliable physiologically acceptable support.
Claim 15
Independent Claim
62 words
A method of stimulating formation of new bone and cartilage in vivo which comprises implanting in a patient in need of such stimulation therapy an implant which comprises a material capable of stimulating formation of new bone and cartilage in vivo derived from demineralized bone by use of aqueous guanidine hydrochloride said material deposited by precipitation onto a pliable physiologically acceptable support.
Claim 16
Dependent Claim
14 words
The method of claim 11 wherein the physiologically acceptable support is a collagen gel.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-20 | 1991-01-19 | 1991-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-20 | 1995-01-19 | 1995-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-20 | 1999-01-19 | 1999-07-21 | $7700.00 | Window Closed / Lapsed |