Burn ointment comprising silver sulfadiazine and collagenase
Abstract
Abstract AN OINTMENT MADE OF SILVER SULFADIAZINE AND COLLAGENASE DISPERSED IN A NON-AQUEOUS HYDROPHOBIC CARRIER, SUCH AS PETROLATUM, HAS BEEN FOUND TO BE USEFUL IN BURN THERAPY. THE SILVER SULFADIAZINE IS PRESENT IN THE OINTMENT IN AN EFFECTIVE ANTIBACTERIAL AMOUNT, SUCH AS AN AMOUNT IN THE RANGE FROM ABOUT 0.1 TO ABOUT 10.0% BY WEIGHT BASED ON SAID OINTMENT. THE COLLAGENASE IS PRESENT IN THE OINTMENT USUALLY IN AN AMOUNT IN THE RANGE FROM ABOUT 0.010.05% TO ABOUT 2.0% BY WEIGHT BASED ON SAID OINTMENT, PETROLATUM IS PREFERRED AS THE NON-AQUEOUS HYDROPHOBIC CARRIER. WHEN APPLIED IN BURN THERAPY THE SILVER SULFADIAZINE COMPONENT OF THE OINTMENT IS ANTIBACTERIAL, FOR EXAMPLE, IS EFFECTIVE AGAINST PSEYDONONAS AERUGINOSA, AND THE COLLAGENASE COMPONENT OF THE OINTMENT APPEARS TO IMPROVE OR ACCELERATE THE SEPARATION OF THE ESCHAR AND PROMOTES HEALING.
Inventors
- 👤 C Fox
Bibliographic Details
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