US4049802A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Zinc sulfadiazine and its use in the treatment of burns
Assignee: Research Corp
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Filing: 1975-03-19
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Granted: 1977-09-20
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Expires: 1995-03-19
Abstract
Abstract Zinc is essential in the complex process of wound healing. Zinc sulfadiazine promotes wound healing and controls infection. When taken into the body, such as by topical application to a wound surface, zinc sulfadiazine dissolves and its dissociation achieves a replacement of zinc lost in the body fluids, such as in the urine, after thermal or other trauma. Although both zinc sulfadiazine and silver sulfadiazine each effectively controls infection and enhances healing in burn wounds, the combination of zinc sulfadiazine and silver sulfadiazine, particularly in a single medicament, possesses enhanced efficacy.
Inventors
- 👤 Charles L. Fox, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/63; A61K31/635; Y; Y10; Y10S; Y10S424/00; Y10S424/13
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
76 words
A composition useful for treating burns consisting essentially of an admixture of silver sulfadiazine and zinc sulfadiazine dispersed as finely divided particles in a water-dispersible hydrophilic carrier, said admixture being present in said composition in an amount to about 10% by weight of said composition and said silver sulfadiazine and said zinc sulfadiazine being present in said composition in an amount of at least 0.1% by weight and 1.0% by weight, respectively, based on said composition.
Claim 2
Dependent Claim
76 words
A composition useful for treating burns consisting essentially of an admixture of silver sulfadiazine and zinc sulfadiazine dispersed as finely divided particles in a water-dispersible hydrophilic carrier, said admixture being present in said composition in an amount to about 10% by weight of said composition and said silver sulfadiazine and said zinc sulfadiazine being present in said composition in an amount of at least 0.1% by weight and 1.0% by weight, respectively, based on said composition.
Claim 3
Dependent Claim
21 words
A composition in accordance with claim 1 containing a minor amount by weight of silver sulfadiazine relative to said zinc sulfadiazine.
Claim 4
Dependent Claim
21 words
A composition in accordance with claim 1 containing a minor amount by weight of zinc sulfadiazine relative to said silver sulfadiazine.
Claim 5
Dependent Claim
19 words
A composition in accordance with claim 1 containing about equal amounts of weight of zinc sulfadiazine and silver sulfadiazine.
Claim 6
Dependent Claim
137 words
A composition useful for treating burns consisting essentially of 0-25% by weight petrolatum, 7-45% by weight of a long chain fatty alcohol having a carbon atom content in the range C 16 -C 22 , an admixture consisting essentially of finely divided silver sulfadiazine and zinc sulfadiazine to about 10% by weight, 4-16% by weight of a non-ionic emusifying agent, 7-40% by weight of a humectant selected from the group consisting of propylene glycol, sorbitol and glycerine, 0-15% by weight of an emollient and an amount of water, when required, sufficient to bring the total of the percentages of the above-identified components to 100%, said silver sulfadiazine and said zinc sulfadiazine of said admixture being present in said composition in an amount of at least 0.1% by weight and 1.0% by weight, respectively, based on said composition.
Claim 7
Dependent Claim
137 words
A composition useful for treating burns consisting essentially of 0-25% by weight petrolatum, 7-45% by weight of a long chain fatty alcohol having a carbon atom content in the range C 16 -C 22 , an admixture consisting essentially of finely divided silver sulfadiazine and zinc sulfadiazine to about 10% by weight, 4-16% by weight of a non-ionic emusifying agent, 7-40% by weight of a humectant selected from the group consisting of propylene glycol, sorbitol and glycerine, 0-15% by weight of an emollient and an amount of water, when required, sufficient to bring the total of the percentages of the above-identified components to 100%, said silver sulfadiazine and said zinc sulfadiazine of said admixture being present in said composition in an amount of at least 0.1% by weight and 1.0% by weight, respectively, based on said composition.
Claim 8
Dependent Claim
22 words
A composition useful for treating burns consisting essentially of 0.1-10% by weight solid particleform zinc sulfadiazine dispersed in a physiologically acceptable carrier.
Claim 9
Dependent Claim
22 words
A composition useful for treating burns consisting essentially of 0.1-10% by weight solid particleform zinc sulfadiazine dispersed in a physiologically acceptable carrier.
Claim 10
Dependent Claim
15 words
A composition in accordance with claim 6 wherein said carrier is a water-dispersible, hydrophilic carrier.
Claim 11
Dependent Claim
93 words
A composition useful for treating burns consisting essentially of 0-25% by weight petrolatum, 7-45% by weight of a long chain fatty alcohol having a carbon content in the range C 16 -C 22 , 0.1-10% by weight finely divided zinc sulfadiazine, 4-16% by weight of a non-ionic emulsifying agent, 7-40% by weight of a humectant selected from a group consisting of propylene glycol, sorbitol and glycerine, 0-15% by weight of an emollient and an amount of water, when required, sufficient to bring the total of the percentages of the above-identified components to 100%.
Claim 12
Dependent Claim
93 words
A composition useful for treating burns consisting essentially of 0-25% by weight petrolatum, 7-45% by weight of a long chain fatty alcohol having a carbon content in the range C 16 -C 22 , 0.1-10% by weight finely divided zinc sulfadiazine, 4-16% by weight of a non-ionic emulsifying agent, 7-40% by weight of a humectant selected from a group consisting of propylene glycol, sorbitol and glycerine, 0-15% by weight of an emollient and an amount of water, when required, sufficient to bring the total of the percentages of the above-identified components to 100%.
Claim 13
Dependent Claim
25 words
A method of treating burns in man or animal which comprises topically applying an effective antibacterial amount of a composition in accordance with claim 1.
Claim 14
Independent Claim
24 words
A method of treating burns in animal or man which comprises topically applying an effective antibacterial amount of zinc sulfadiazine to the affected surface.
Claim 15
Independent Claim
24 words
A method of treating burns in animal or man which comprises topically applying an effective antibacterial amount of zinc sulfadiazine to the affected surface.
Claim 16
Dependent Claim
42 words
A method in accordance with claim 10 wherein said zinc sulfadiazine is applied as a dispersion in a water-dispersible, hydrophilic carrier, said carrier containing an amount in the range from about 0.1 to about 10% by weight of zinc sulfadiazine dispersed therein.
Claim 17
Dependent Claim
21 words
A method in accordance with claim 10 wherein said zinc sulfadiazine is applied as a dispersion in a water-dispersible, hydrophilic carrier.
Claim 18
Dependent Claim
98 words
A method in accordance with claim 12 wherein said dispersion consists essentially of 0-25% by weight petrolatum, 7-45% by weight of a long chain fatty alcohol having a carbon atom content in the range C 16 -C 22 , 0.1-10% by weight finely divided zinc sulfadiazine, 4-16% by weight of a non-ionic emulsifying agent, 7-40% by weight of a humectant selected from the group consisting of propylene glycol, sorbitol and glycerine, 0-15% by weight of an emollient and an amount of water, when required, sufficient to bring the total of the percentages of the above-identified components to 100%.
Claim 19
Independent Claim
33 words
A method of treating burns in animal or man which comprises separately topically applying an effective antibacterial amount of silver sulfadiazine and an effective antibacterial amount of zinc sulfadiazine to the affected surface.
Claim 20
Independent Claim
33 words
A method of treating burns in animal or man which comprises separately topically applying an effective antibacterial amount of silver sulfadiazine and an effective antibacterial amount of zinc sulfadiazine to the affected surface.
Claim 21
Dependent Claim
21 words
A method in accordance with claim 14 wherein said zinc sulfadiazine is applied subsequent to the application of said silver sulfadiazine.
Claim 22
Dependent Claim
41 words
A method in accordance with claim 14 wherein said silver sulfadiazine is first applied to the affected surface for a period of about 1-10 days and upon discontinuing the application of said silver sulfadiazine applying zinc sulfadiazine to the affected surface.
Claim 23
Dependent Claim
21 words
A method in accordance with claim 14 wherein said silver sulfadiazine is applied subsequent to the application of said zinc sulfadiazine.
Claim 24
Dependent Claim
2 words
Zinc sulfadiazine.
Claim 25
Dependent Claim
2 words
Zinc sulfadiazine.
References Cited (Backward Citations)
GB1240546A
Cited
US3761590A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-19 | 1981-03-21 | 1981-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-19 | 1985-03-21 | 1985-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-19 | 1989-03-21 | 1989-09-20 | $7700.00 | Window Closed / Lapsed |