Patent US2984822A successfully refreshed from Google Patents.
Patent US4479795A successfully refreshed from Google Patents.
US4479795A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antimicrobial polymer compositions
Assignee: Procter and Gamble Co
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Filing: 1982-07-27
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Granted: 1984-10-30
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Expires: 2002-07-27
Abstract
Abstract The present invention relates to medical polymers and devices made therefrom, and is based on the discovery that certain carboxylate antimicrobial agents can be releasably incorporated into permeable polymers. The walls of medical devices such as catheters can be fashioned from such polymers. In use, the antimicrobial agent diffuses from the walls to the surface of the device to form an antimicrobial barrier on the surface of the device and a zone of microbial inhibition on tissue surfaces surrounding the device, thereby effectively supplementing the body's own natural microbial barriers where they have been compromised. The bacterial contamination-resistant carboxylate-plus-polymer compositions herein can be used in the manufacture of a wide variety of medical devices, especially urinary catheters, intravenous catheters, wound dressings, and the like.
Inventors
- 👤 Robert V. Mustacich
- 👤 Donald S. Lucas
- 👤 Roger L. Stone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:51
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A01; A01N; A01N37/00; A01N37/02; A01N37/06; A61L15/00; A61L15/16; A61L15/42; A61L15/46; A61L2300/00; A61L2300/20; A61L2300/21; A61L2300/40; A61L2300/404
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
176 words
A method for catheterization of humans and lower animals with lowered risk of nosocomial infection by achieving microbial inhibition at and around the placement site of catheters and the like used in the bodies of humans and lower animals, comprising: inserting into the body of a human or lower animal in need of such treatment a catheter, or the like, said catheter comprising: delivery means for transporting liquid materials, said delivery means being in the form of a tube; at least part of the portion of said tube which contacts the body comprising a toxicologically-acceptable, medical-grade elastomeric polymer, said polymer having releasably incorporated within the polymer matrix a safe and effective amount of one or more free n-alkane monocarboxylic acid antimicrobial agents or salts thereof, having from about 4 to about 10 carbon atoms, said polymer containing from about 0.1% to about 40% by weight of a substantially non-antimicrobial proton donor selected from the group consisting of citric acid, tartaric acid, malic acid, fumaric acid, maleic acid, malonic acid, ascorbic acid, barbituric acid, and mixtures thereof.
Claim 2
Independent Claim
176 words
A method for catheterization of humans and lower animals with lowered risk of nosocomial infection by achieving microbial inhibition at and around the placement site of catheters and the like used in the bodies of humans and lower animals, comprising: inserting into the body of a human or lower animal in need of such treatment a catheter, or the like, said catheter comprising: delivery means for transporting liquid materials, said delivery means being in the form of a tube; at least part of the portion of said tube which contacts the body comprising a toxicologically-acceptable, medical-grade elastomeric polymer, said polymer having releasably incorporated within the polymer matrix a safe and effective amount of one or more free n-alkane monocarboxylic acid antimicrobial agents or salts thereof, having from about 4 to about 10 carbon atoms, said polymer containing from about 0.1% to about 40% by weight of a substantially non-antimicrobial proton donor selected from the group consisting of citric acid, tartaric acid, malic acid, fumaric acid, maleic acid, malonic acid, ascorbic acid, barbituric acid, and mixtures thereof.
Claim 3
Dependent Claim
32 words
A method according to claim 1 wherein the carboxylate antimicrobial agent is in the form of the protonated acid and comprises from about 0.01% to about 60% by weight of the composition.
Claim 4
Dependent Claim
31 words
A method according to claim 1 wherein the antimicrobial agent is in the form of a pharmaceutically-acceptable salt and comprises from about 0.01% to about 60% by weight of the composition.
Claim 5
Dependent Claim
19 words
A method according to claim 1 wherein the carboxylate antimicrobial agent is a C 6 -C 10 n-alkane carboxylate.
Claim 6
Dependent Claim
24 words
A method according to claim 4 wherein the antimicrobial agent is selected from the group consisting of octanoic acid, sodium octanoate, and mixtures thereof.
Claim 7
Dependent Claim
24 words
A method according to claim 5 wherein the antimicrobial agent is selected from the group consisting of decanoic acid, sodium decanoate, and mixtures thereof.
Claim 8
Dependent Claim
27 words
A method according to claim 1 wherein the antimicrobial agent is in the form of one or more pharmaceutically-acceptable alkali metal salts of the n-alkane monocarboxylic acids.
Claim 9
Dependent Claim
27 words
A method according to claim 7, wherein the antimicrobial agent is in the form of one or more pharmaceutically-acceptable alkali metal salts of the n-alkane monocarboxylic acids.
References Cited (Backward Citations)
US1772975A
Cited
US2190714A
Cited
US2154449A
Cited
US2466663A
Cited
US2589445A
Cited
US2729586A
Cited
US3070559A
Cited
US3279996A
Cited
US3524447A
Cited
US3434869A
Cited
US3404987A
Cited
US3598126A
Cited
US3598127A
Cited
US3566874A
Cited
US3854480A
Cited
US3608063A
Cited
US3708324A
Cited
US3663965A
Cited
US3695921A
Cited
US3767803A
Cited
US3897376A
Cited
US3699956A
Cited
US3996934A
Cited
US3886947A
Cited
US4002775A
Cited
US3848603A
Cited
US3926705A
Cited
US3940430A
Cited
US4012497A
Cited
US4012496A
Cited
US4186745A
Cited
US4193403A
Cited
US4159720A
Cited
US4280500A
Cited
US4327725A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-30 | 1988-04-30 | 1988-10-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-30 | 1992-04-30 | 1992-10-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-30 | 1996-04-30 | 1996-10-30 | $7700.00 | Window Closed / Lapsed |