US3608063A
Expired / Lapsed
US
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Molecular drug entrapment process and compositions
Assignee: GILBERT S BANKER
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Filing: 1969-08-15
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Granted: 1971-09-21
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Expires: 1989-08-15
Abstract
Abstract Pharmaceutical compositions are prepared by combining in the presence of water and a carboxylic acid a polymer having acidic or basic functionality with a pharmaceutically active material having respectively basic or acidic functionality, coagulating or otherwise separating the product produced and then formulating the product by conventional techniques into suitable dosage forms. The resulting products are characterized by possessing unique sustained-release, enteric or delayed-release properties.
Inventors
- 👤 Gilbert S Banker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:28
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
12 words
A process in accordance with claim 1 wherein said acid is polycarboxylic.
Claim 2
Dependent Claim
16 words
A process in accordance with claim 1 wherein said acid is a water-soluble, aliphatic dicarboxylic acid.
Claim 3
Dependent Claim
45 words
A process in accordance with claim 1 wherein said carboxylic acid is selected from the group consisting of acetic acid, glycine, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, citric acid, tartaric acid, ascorbic acid, and the phthalic acids.
Claim 4
Dependent Claim
212 words
An oral dosage pharmaceutical composition produced in accordance with the process of claim 6, characterized by controlled release comprising a pharmaceutically active acidic or basic drug or a drug that is both acidic and basic chemisorbed on the molecular-to-ionic scale in an aqueous dispersing medium in which said drug is at least partially soluble to latex particles of a physiologically harmless basic or acidic polymer or a polymer that is both acidic and basic that is hydratable in the gastrointestinal tract, said polymer being a preformed product of emulsion polymerization and sufficiently functionally reactive to chemisorb said drug on the molecular-to-ionic scale whereby the major portion of the drug is available for dialysis, and only a minor portion of the drug is permanently bound by the polymer and is unavailable for gastrointestinal absorption, and further containing a substantial amount of physiologically harmless, at least slightly water-soluble, carboxylic acid selected from the group consisting of acetic acid, aminoacetic acid, polycarboxylic aliphatic acids, citric acid, tartaric acid, ascorbic acid, and the phthalic acids chemisorbed from the aqueous dispersing medium in which said acid is at least partially dissolved with said drug to said latex particles, said composition exhibiting more prolonged release at a buffered pH of 4.5 than the composition free of said acid.
Claim 5
Dependent Claim
45 words
A composition in accordance with claim 5 wherein said carboxylic acid is selected from the group consisting of acetic acid, glycine, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, citric acid, tartaric acid, ascorbic acid, and the phthalic acids.
Claim 6
Dependent Claim
12 words
A composition in accordance with claim 5 wherein said acid is polyfunctional.
Claim 7
Dependent Claim
12 words
A composition in accordance with claim 7 wherein said acid is polycarboxylic.
Claim 8
Dependent Claim
16 words
A composition in accordance with claim 5 wherein said acid is a water-soluble, aliphatic dicarboxylic acid.
Claim 9
Dependent Claim
29 words
A composition in accordance with claim 5 wherein said polymer is an acrylic polymer leaving acid functionally and said drug is a basic drug containing a basic nitrogen group.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-09-20 | 1975-03-22 | 1975-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-09-20 | 1979-03-22 | 1979-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-09-20 | 1983-03-22 | 1983-09-21 | $7700.00 | Window Closed / Lapsed |