Patent US3820713A successfully refreshed from Google Patents.
Patent US4349467A successfully refreshed from Google Patents.
US4349467A
Expired / Lapsed
US
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Nonthrombogenic articles and method of preparation
Assignee: Individual
•
Filing: 1979-09-17
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Granted: 1982-09-14
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Expires: 1999-09-17
Abstract
Abstract The disclosure is of articles having reduced thrombogenicity and which are useful for purposes requiring their contact with whole blood. The articles comprise solid, polymeric resin substrates to which there is fixed a compound of the formula: ##STR1## wherein R 1 is alkyl of 12 to 18 carbon atoms, inclusive; R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen and lower alkyl; X represents a negative monovalent ion such as halogen; and A represents the residue of a salt of heparin after removal of the positive ion. The articles advantageously exhibit low toxicity and excellent blood compatibility when used for purposes which bring them into contact with whole blood for prolonged periods of time.
Inventors
- 👤 Joel L. Williams
- 👤 Betty J. Dudley, deceased
- 👤 executor by Kenneth H. Dudley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:42
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; C08L; C08L5/00; C08L5/10
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
65 words
In a method for reducing the thrombogenicity of a solid polymeric resin, which comprises absorbing a quaternary ammonium salt on the surface of the resin and then contacting the surface with the absorbed salt, with a solution of heparin, the improvement which comprises; employing as said solution one containing a concentration of heparin within the range of from about 5 percent by weight to saturation.
Claim 2
Dependent Claim
65 words
In a method for reducing the thrombogenicity of a solid polymeric resin, which comprises absorbing a quaternary ammonium salt on the surface of the resin and then contacting the surface with the absorbed salt, with a solution of heparin, the improvement which comprises; employing as said solution one containing a concentration of heparin within the range of from about 5 percent by weight to saturation.
Claim 3
Dependent Claim
57 words
The improved method of claim 1 wherein the quaternary ammonium salt is a compound of the formula: ##STR5## wherein R 1 is alkyl of 12 to 18 carbon atoms, R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen and lower alkyl; and X represents a negative monovalent ion.
Claim 4
Dependent Claim
24 words
The improved method of claim 2 wherein R 2 is lower alkyl, R 3 and R 4 are each hydrogen and X is halogen.
Claim 5
Dependent Claim
10 words
The improved method of claim 3 where X is chloride.
Claim 6
Dependent Claim
27 words
The improved method of claim 4 wherein the compound is selected from the group consisting of dodecylmethylammonium chloride, tetradecylmethylammonium chloride, hexadecylmethylammonium chloride, octadecylmethylammonium chloride and dodecylhexylammonium chloride.
Claim 7
Dependent Claim
19 words
The improved method of claim 1 wherein the concentration of heparin is from about 9 to about 15 percent.
Claim 8
Dependent Claim
88 words
An article for use in association with whole blood, which comprises; a solid, polymeric resin substrate; and a compound of the formula: ##STR6## wherein R 1 is alkyl of 12 to 18 carbon atoms, inclusive; R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen and lower alkyl; and A represents the negative ion of a salt of heparin, affixed to said substrate in a proportion of at least 6.61 μg of heparin per cm 2 of the substrate surface.
Claim 9
Dependent Claim
88 words
An article for use in association with whole blood, which comprises; a solid, polymeric resin substrate; and a compound of the formula: ##STR6## wherein R 1 is alkyl of 12 to 18 carbon atoms, inclusive; R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen and lower alkyl; and A represents the negative ion of a salt of heparin, affixed to said substrate in a proportion of at least 6.61 μg of heparin per cm 2 of the substrate surface.
Claim 10
Dependent Claim
10 words
The article of claim 7 wherein said resin comprises polyethylene.
Claim 11
Dependent Claim
10 words
The article of claim 7 wherein said resin is polyurethane.
Claim 12
Dependent Claim
10 words
The article of claim 7 wherein said resin is polytetrafluoroethylene.
Claim 13
Dependent Claim
11 words
The article of claim 7 wherein said resin is polyvinyl chloride.
Claim 14
Dependent Claim
11 words
The article of claim 7 wherein said resin is silicone rubber.
Claim 15
Dependent Claim
37 words
The article of claim 7 wherein the resin is selected from the group consisting of polyethylene, polyacrylics, polypropylene, polyvinyl chloride, polyamides, polyurethanes, polyvinylpyrrolidone, polyvinyl alcohols, cellulose acetate, polystyrene, polytetrafluoroethylene, polyoxymethylene, polyesters, silicone rubber, natural rubber and polycarbonates.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-09-13 | 1986-03-15 | 1986-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-13 | 1990-03-15 | 1990-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-13 | 1994-03-15 | 1994-09-14 | $7700.00 | Window Closed / Lapsed |