US4289499A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Selecting perfluorocarbon compounds for synthetic blood
Assignee: Cincinnati Children's Hospital Medical Center
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Filing: 1980-09-22
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Granted: 1981-09-15
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Expires: 2000-09-22
Abstract
Abstract A process for selecting a perfluorocarbon compound from those having about 9 to 12 carbon atoms for preparing synthetic blood compositions. The process involves determining the critical solution temperature of the perfluorocarbon compound in a solvent such as n-hexane. The perfluorocarbon compound is accepted as suitable for preparing a synthetic blood composition if its critical solution temperature falls below a selected temperature set by the number of carbon atoms in the perfluorocarbon compound.
Inventors
- 👤 Leland C. Clark, Jr.
- 👤 Robert E. Moore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/106664
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
126 words
A process for selecting perfluorocarbon compounds from those having from about 9 to 12 carbon atoms for preparing synthetic blood compositions comprising: (a) dissolving a candidate perfluorocarbon compound in a solvent; (b) determining the critical solution temperature of said candidate perfluorocarbon; and (c) accepting the candidate perfluorocarbon compound for preparing a synthetic blood composition when said candidate compound has a critical solution temperature of less than; (1) a first temperature when the perfluorocarbon has nine carbon atoms; (2) a second temperature when the perfluorocarbon has ten carbon atoms; (3) a third temperature when the perfluorocarbon has eleven carbon atoms; (4) a fourth temperature when the perfluorocarbon has twelve atoms; and whereby the accepted perfluorocarbon compound has a transpiration rate in animals falling within a predetermined range.
Claim 2
Dependent Claim
126 words
A process for selecting perfluorocarbon compounds from those having from about 9 to 12 carbon atoms for preparing synthetic blood compositions comprising: (a) dissolving a candidate perfluorocarbon compound in a solvent; (b) determining the critical solution temperature of said candidate perfluorocarbon; and (c) accepting the candidate perfluorocarbon compound for preparing a synthetic blood composition when said candidate compound has a critical solution temperature of less than; (1) a first temperature when the perfluorocarbon has nine carbon atoms; (2) a second temperature when the perfluorocarbon has ten carbon atoms; (3) a third temperature when the perfluorocarbon has eleven carbon atoms; (4) a fourth temperature when the perfluorocarbon has twelve atoms; and whereby the accepted perfluorocarbon compound has a transpiration rate in animals falling within a predetermined range.
Claim 3
Dependent Claim
13 words
The process of claim 1 wherein the candidate perfluorocarbon is a cyclic perfluorocarbon.
Claim 4
Dependent Claim
13 words
The process of claim 1 wherein the candidate perfluorocarbon is a paraffinic fluorocarbon.
Claim 5
Dependent Claim
122 words
A process for selecting perfluorocarbon compounds from those having from about 9 to 12 carbon atoms for preparing synthetic blood compositions comprising: (a) dissolving a candidate perfluorocarbon compound in n-hexane; (b) determining the critical solution temperature of said candidate perfluorocarbon; and (c) accepting the candidate perfluorocarbon compound for preparing a synthetic blood composition when said candidate compound has a critical solution temperature of less than: (1) 20° C. when the perfluorocarbon has nine carbon atoms; (2) 30° C. when the perfluorocarbon has ten carbon atoms; (3) 35° C. when the perfluorocarbon has eleven carbon atoms; (4) 45° C. when the perfluorocarbon has twelve carbon atoms; and whereby the accepted perfluorocarbon compound has a transpiration rate in animals falling within a predetermined range.
Claim 6
Dependent Claim
122 words
A process for selecting perfluorocarbon compounds from those having from about 9 to 12 carbon atoms for preparing synthetic blood compositions comprising: (a) dissolving a candidate perfluorocarbon compound in n-hexane; (b) determining the critical solution temperature of said candidate perfluorocarbon; and (c) accepting the candidate perfluorocarbon compound for preparing a synthetic blood composition when said candidate compound has a critical solution temperature of less than: (1) 20° C. when the perfluorocarbon has nine carbon atoms; (2) 30° C. when the perfluorocarbon has ten carbon atoms; (3) 35° C. when the perfluorocarbon has eleven carbon atoms; (4) 45° C. when the perfluorocarbon has twelve carbon atoms; and whereby the accepted perfluorocarbon compound has a transpiration rate in animals falling within a predetermined range.
Claim 7
Dependent Claim
13 words
The process of claim 4 wherein the candidate perfluorocarbon is a cyclic perfluorocarbon.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-14 | 1985-03-16 | 1985-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-14 | 1989-03-16 | 1989-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-14 | 1993-03-16 | 1993-09-15 | $7700.00 | Window Closed / Lapsed |