Patent US4245634A successfully refreshed from Google Patents.
US4245634A
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Artificial beta cell
Assignee: Hospital for Sick Children
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Filing: 1979-02-12
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Granted: 1981-01-20
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Expires: 1999-02-12
Abstract
Abstract An artificial beta cell regulates blood glucose concentration in a subject by continuously analyzing blood from the patient and deriving a computer output signal to drive a pump which infuses insulin at a rate corresponding to the signal. A value of blood glucose concentration from the analyzed blood is used by a computer to determine a rate of change of this concentration which in turn is used to derive a projected blood glucose level. A sigmoidal relationship between the projected blood glucose concentration and the rate of infusion is used to determine the actual rate of infusion required and hence an output signal is fed to the pump to create this actual rate of insulin infusion.
Inventors
- 👤 Anthony M. Albisser
- 👤 Bernard S. Leibel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:50
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
203 words
An artificial beta cell comprising: blood analysis means for determining serial values of blood glucose concentration in the blood (BG) and including signal means for providing input signals corresponding to said values; means coupled to the blood analysis means to receive said input signals and including, first means for deriving serial values of the rate of change of blood glucose concentration in the blood (BG), second means receiving said values of BG and deriving a difference factor (DF) in accordance with a function of BG which is monotonic and symmetrical in the first and third quadrants, and has a slope which is never negative and which is smaller adjacent the origin than it is remote from the origin, and third means receiving DF and adding corresponding values of DF and BG to give a projected blood glucose concentration (PBG), and fourth means for deriving a desired rate of insulin infusion (RI) using the derived value of PBG from a sigmoidal relationship between PBG and RI and providing an output signal corresponding to the desired value of RI; and pump means coupled to receive the output signal and responsive to the output signal to supply the desired rate of insulin infusion to the subject.
Claim 2
Dependent Claim
203 words
An artificial beta cell comprising: blood analysis means for determining serial values of blood glucose concentration in the blood (BG) and including signal means for providing input signals corresponding to said values; means coupled to the blood analysis means to receive said input signals and including, first means for deriving serial values of the rate of change of blood glucose concentration in the blood (BG), second means receiving said values of BG and deriving a difference factor (DF) in accordance with a function of BG which is monotonic and symmetrical in the first and third quadrants, and has a slope which is never negative and which is smaller adjacent the origin than it is remote from the origin, and third means receiving DF and adding corresponding values of DF and BG to give a projected blood glucose concentration (PBG), and fourth means for deriving a desired rate of insulin infusion (RI) using the derived value of PBG from a sigmoidal relationship between PBG and RI and providing an output signal corresponding to the desired value of RI; and pump means coupled to receive the output signal and responsive to the output signal to supply the desired rate of insulin infusion to the subject.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-20 | 1984-07-21 | 1985-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-20 | 1988-07-21 | 1989-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-20 | 1992-07-21 | 1993-01-20 | $7700.00 | Window Closed / Lapsed |