US4055175A
Expired / Lapsed
US
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Blood glucose control apparatus
Assignee: Bayer Corp
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Filing: 1976-05-07
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Granted: 1977-10-25
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Expires: 1996-05-07
Abstract
Abstract Apparatus is described for controlling blood glucose concentration in a subject by selected infusion of insulin and/or glucose, depending upon the general blood glucose concentration. This apparatus comprises in combination sensor means for measuring the blood glucose concentration and for providing computer input signals based on such measurement, computer means for receiving such input signals and being programmed to provide output signals based upon such input signals, and pump means responsive to such computer output signals to supply insulin and/or glucose to such subject at a rate determined by such output signals. The computer derives the output signals in accordance with specific quadratic and biquadratic equations employing certain independently selected values relating to basal blood glucose concentrations and basal insulin and glucose infusion rates at such basal blood glucose concentrations.
Inventors
- 👤 Anton Hubert Clemens
- 👤 Robert Weston Myers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:43
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723; A61B; A61B5/00; A61B5/145; A61B5/14532
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
263 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon both the particular concentration of glucose in said blood stream and the rate of change of said blood glucose concentration comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU5## wherein IR = calculated insulin infusion rate BI = basal glucose concentration RI = desired basal insulin infusion rate at BI g = measured previous serial blood glucose reading and BI, RI, and QI are preselected values and wherein if the blood glucose concentration is rising GD =(K.sub.R A.sup.2 10) + 6A wherein A is the average change in blood gulcose concentration over several previous serial readings and K R is a preselected value and wherein if the blood glucose concentration is falling GD = (K.sub.F A.sup.2 10) + 6A wherein A is the same as above and K F is a preselected value which is different from and less than K R , said GD being substracted from G in the above equation when the blood glucose concentration is falling.
Claim 2
Dependent Claim
263 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon both the particular concentration of glucose in said blood stream and the rate of change of said blood glucose concentration comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU5## wherein IR = calculated insulin infusion rate BI = basal glucose concentration RI = desired basal insulin infusion rate at BI g = measured previous serial blood glucose reading and BI, RI, and QI are preselected values and wherein if the blood glucose concentration is rising GD =(K.sub.R A.sup.2 10) + 6A wherein A is the average change in blood gulcose concentration over several previous serial readings and K R is a preselected value and wherein if the blood glucose concentration is falling GD = (K.sub.F A.sup.2 10) + 6A wherein A is the same as above and K F is a preselected value which is different from and less than K R , said GD being substracted from G in the above equation when the blood glucose concentration is falling.
Claim 3
Dependent Claim
121 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon the particualr concentration of glucose in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU6##wherein
Claim 4
Dependent Claim
121 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon the particualr concentration of glucose in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU6##wherein
Claim 5
Dependent Claim
6 words
IR = calculated insulin infusion rate
Claim 6
Dependent Claim
6 words
IR = calculated insulin infusion rate
Claim 7
Dependent Claim
5 words
BI = basal glucose concentration
Claim 8
Dependent Claim
5 words
BI = basal glucose concentration
Claim 9
Dependent Claim
9 words
RI = desired basal insulin infusion rate at BI
Claim 10
Dependent Claim
9 words
RI = desired basal insulin infusion rate at BI
Claim 11
Dependent Claim
14 words
G = measured previous glucose reading and BI, RI and QI are preselected values.
Claim 12
Dependent Claim
14 words
G = measured previous glucose reading and BI, RI and QI are preselected values.
Claim 13
Dependent Claim
252 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon the rate of change of glucose concentration in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU7## wherein IR = calculated insulin infusion rate Bi = basal glucose concentration RI = desired basal insulin infusion rate at BI g = measured previous glucose reading and BI, RI and QI are preselected values and wherein if the blood glucose concentration is rising GD = (K.sub.R A.sup.2 10) = 6A wherein A = the average change in blood concentration over several previous serial readings and K R is a preselected value and wherein if the blood glucose concentration is falling GD = (K.sub.F A.sup.2 10) = 6A wherein A is the same as above and K F is a preselected value which is different from and less than K R , said GD being substracted from G in the above equation when the blood glucose concentration is falling.
Claim 14
Dependent Claim
252 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon the rate of change of glucose concentration in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU7## wherein IR = calculated insulin infusion rate Bi = basal glucose concentration RI = desired basal insulin infusion rate at BI g = measured previous glucose reading and BI, RI and QI are preselected values and wherein if the blood glucose concentration is rising GD = (K.sub.R A.sup.2 10) = 6A wherein A = the average change in blood concentration over several previous serial readings and K R is a preselected value and wherein if the blood glucose concentration is falling GD = (K.sub.F A.sup.2 10) = 6A wherein A is the same as above and K F is a preselected value which is different from and less than K R , said GD being substracted from G in the above equation when the blood glucose concentration is falling.
Claim 15
Dependent Claim
155 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of glucose to such subject dependent upon the particular concentration of glucose in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying glucose to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU8##wherein DR = calculated glucose infusion rate BD = basal glucose concentration RD = desired basal glucose infusion rate at BD g = measured previous glucose reading and BD, RD and QD are preselected values.
Claim 16
Dependent Claim
155 words
Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of glucose to such subject dependent upon the particular concentration of glucose in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values; computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and pump means responsive to said output signals for supplying glucose to such subject at a rate determined by said output signals; said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU8##wherein DR = calculated glucose infusion rate BD = basal glucose concentration RD = desired basal glucose infusion rate at BD g = measured previous glucose reading and BD, RD and QD are preselected values.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-24 | 1981-04-25 | 1981-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-24 | 1985-04-25 | 1985-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-24 | 1989-04-25 | 1989-10-25 | $7700.00 | Window Closed / Lapsed |