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US3914402A Expired / Lapsed US ⏱️ 0.0 years remaining

Ophthalmic dosage form, for releasing medication over time

Assignee: Alza Corp
•
Filing: 1973-06-14
•
Granted: 1975-10-21
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Expires: 1993-06-14
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Abstract

Abstract A dosage form for ophthalmic drugs is disclosed. The dosage form is a suspension of 10 to 300 micron particles in a liquid medium. The particles are made up of drug enclosed within a drug release rate-controlling material which bioerodes in the environment of the eye.

Inventors

  • 👤 John W Shell

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 07:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/0012; A61K9/0048; A61K9/0051; A61K9/1635; A61K9/1658

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 145 words
AN OPHTHALMIC DOSAGE FORM COMPRISING SUBSTANTIALLY DRY SOLID PARTICLES OF OPHTHALMIC DRUG ENCLOSED WITHIN A BIOERODIBLE RELEASE RATE CONTROLLING MATERIAL FORMED OF A HYDROPHOBIC POLY(CARBOXYLIC ACID) HAVING A MOLECULAR WEIGHT OF ABOUT 10,000 TO ABOUT 800,000 AND CONTAINING 8 TO 22 CARBON ATOMS FOR EACH CARBOXYLIC HYDROGEN WITH THE PARTICLES CONSISTING OF ABOUT 8 PARTS DRUG UP TO 1 PART MATERIAL TO ABOUT 1 PART DRUG UP TO ABOUT 3 PARTS MATERIAL, SAID PARTICLES BEING FROM 10 TO 300 MICRONS IN LARGEST DIMENSIONS AND FORMING A SUSPENSION OF 1 PART TO 50 PARTS WHEN ADMIXED PRIOR TO ADMINISTRATION WITH UP TO 100 PARTS OF AN OPHTHALMICALLY ACCEPTABLE ISOTONIC AQUEOUS CARRIER HAVING A PH ACCEPTABLE TO THE EYE, WITH DRUG RELEASED IN THE EYE AS THE PARTICLES ERODE IN RESPONSE TO THE ACULAR ENVIRONMENT IN A CONTROLLED AND CONTINUOUS RATE OVER A PROLONGED PERIOD OF TIME.
Claim 2
Dependent Claim 145 words
AN OPHTHALMIC DOSAGE FORM COMPRISING SUBSTANTIALLY DRY SOLID PARTICLES OF OPHTHALMIC DRUG ENCLOSED WITHIN A BIOERODIBLE RELEASE RATE CONTROLLING MATERIAL FORMED OF A HYDROPHOBIC POLY(CARBOXYLIC ACID) HAVING A MOLECULAR WEIGHT OF ABOUT 10,000 TO ABOUT 800,000 AND CONTAINING 8 TO 22 CARBON ATOMS FOR EACH CARBOXYLIC HYDROGEN WITH THE PARTICLES CONSISTING OF ABOUT 8 PARTS DRUG UP TO 1 PART MATERIAL TO ABOUT 1 PART DRUG UP TO ABOUT 3 PARTS MATERIAL, SAID PARTICLES BEING FROM 10 TO 300 MICRONS IN LARGEST DIMENSIONS AND FORMING A SUSPENSION OF 1 PART TO 50 PARTS WHEN ADMIXED PRIOR TO ADMINISTRATION WITH UP TO 100 PARTS OF AN OPHTHALMICALLY ACCEPTABLE ISOTONIC AQUEOUS CARRIER HAVING A PH ACCEPTABLE TO THE EYE, WITH DRUG RELEASED IN THE EYE AS THE PARTICLES ERODE IN RESPONSE TO THE ACULAR ENVIRONMENT IN A CONTROLLED AND CONTINUOUS RATE OVER A PROLONGED PERIOD OF TIME.
Claim 3
Dependent Claim 39 words
An ophthalmic dosage form according to claim 1 wherein the ophthalmic drug is a member selected from the group consisting of idoxuridine, phenylephrine, pilocarpine and its acceptable salts, eserine, carbachol, phospholine iodine, demecarium bromide, cyclopentolate, homatropine, scopolamine and epinephrine.
Claim 4
Dependent Claim 39 words
An ophthalmic dosage form according to claim 1 wherein the drug is an ophthalmic steroid selected from the group consisting of hydrocortisone, hydrocortisone acetate, dexamethasone, dexamethasone 21-phosphate, fluocinolone, medrysone, prednisolone, methylprednisolone, prednisolone 21-phosphate, prednisolone acetate, fluorometholone, betamethasone and triamcinoline.
Claim 5
Dependent Claim 33 words
An ophthalmic dosage form according to claim 1 wherein te drug is an ophthalmic antibiotic selected from the group consisting of tetracycline, chlorotetracycline, bacitracin, neomycin, polymyxin, gramicidin, oxytetracycline, chloramphenicol, gentamycin, pencillin and erythromycin.

References Cited (Backward Citations)

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-10-20 1979-04-21 1979-10-21 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-10-20 1983-04-21 1983-10-21 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-10-20 1987-04-21 1987-10-21 $7700.00 Window Closed / Lapsed

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