US3914402A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ophthalmic dosage form, for releasing medication over time
Assignee: Alza Corp
•
Filing: 1973-06-14
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Granted: 1975-10-21
•
Expires: 1993-06-14
Abstract
Abstract A dosage form for ophthalmic drugs is disclosed. The dosage form is a suspension of 10 to 300 micron particles in a liquid medium. The particles are made up of drug enclosed within a drug release rate-controlling material which bioerodes in the environment of the eye.
Inventors
- 👤 John W Shell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/0012; A61K9/0048; A61K9/0051; A61K9/1635; A61K9/1658
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
145 words
AN OPHTHALMIC DOSAGE FORM COMPRISING SUBSTANTIALLY DRY SOLID PARTICLES OF OPHTHALMIC DRUG ENCLOSED WITHIN A BIOERODIBLE RELEASE RATE CONTROLLING MATERIAL FORMED OF A HYDROPHOBIC POLY(CARBOXYLIC ACID) HAVING A MOLECULAR WEIGHT OF ABOUT 10,000 TO ABOUT 800,000 AND CONTAINING 8 TO 22 CARBON ATOMS FOR EACH CARBOXYLIC HYDROGEN WITH THE PARTICLES CONSISTING OF ABOUT 8 PARTS DRUG UP TO 1 PART MATERIAL TO ABOUT 1 PART DRUG UP TO ABOUT 3 PARTS MATERIAL, SAID PARTICLES BEING FROM 10 TO 300 MICRONS IN LARGEST DIMENSIONS AND FORMING A SUSPENSION OF 1 PART TO 50 PARTS WHEN ADMIXED PRIOR TO ADMINISTRATION WITH UP TO 100 PARTS OF AN OPHTHALMICALLY ACCEPTABLE ISOTONIC AQUEOUS CARRIER HAVING A PH ACCEPTABLE TO THE EYE, WITH DRUG RELEASED IN THE EYE AS THE PARTICLES ERODE IN RESPONSE TO THE ACULAR ENVIRONMENT IN A CONTROLLED AND CONTINUOUS RATE OVER A PROLONGED PERIOD OF TIME.
Claim 2
Dependent Claim
145 words
AN OPHTHALMIC DOSAGE FORM COMPRISING SUBSTANTIALLY DRY SOLID PARTICLES OF OPHTHALMIC DRUG ENCLOSED WITHIN A BIOERODIBLE RELEASE RATE CONTROLLING MATERIAL FORMED OF A HYDROPHOBIC POLY(CARBOXYLIC ACID) HAVING A MOLECULAR WEIGHT OF ABOUT 10,000 TO ABOUT 800,000 AND CONTAINING 8 TO 22 CARBON ATOMS FOR EACH CARBOXYLIC HYDROGEN WITH THE PARTICLES CONSISTING OF ABOUT 8 PARTS DRUG UP TO 1 PART MATERIAL TO ABOUT 1 PART DRUG UP TO ABOUT 3 PARTS MATERIAL, SAID PARTICLES BEING FROM 10 TO 300 MICRONS IN LARGEST DIMENSIONS AND FORMING A SUSPENSION OF 1 PART TO 50 PARTS WHEN ADMIXED PRIOR TO ADMINISTRATION WITH UP TO 100 PARTS OF AN OPHTHALMICALLY ACCEPTABLE ISOTONIC AQUEOUS CARRIER HAVING A PH ACCEPTABLE TO THE EYE, WITH DRUG RELEASED IN THE EYE AS THE PARTICLES ERODE IN RESPONSE TO THE ACULAR ENVIRONMENT IN A CONTROLLED AND CONTINUOUS RATE OVER A PROLONGED PERIOD OF TIME.
Claim 3
Dependent Claim
39 words
An ophthalmic dosage form according to claim 1 wherein the ophthalmic drug is a member selected from the group consisting of idoxuridine, phenylephrine, pilocarpine and its acceptable salts, eserine, carbachol, phospholine iodine, demecarium bromide, cyclopentolate, homatropine, scopolamine and epinephrine.
Claim 4
Dependent Claim
39 words
An ophthalmic dosage form according to claim 1 wherein the drug is an ophthalmic steroid selected from the group consisting of hydrocortisone, hydrocortisone acetate, dexamethasone, dexamethasone 21-phosphate, fluocinolone, medrysone, prednisolone, methylprednisolone, prednisolone 21-phosphate, prednisolone acetate, fluorometholone, betamethasone and triamcinoline.
Claim 5
Dependent Claim
33 words
An ophthalmic dosage form according to claim 1 wherein te drug is an ophthalmic antibiotic selected from the group consisting of tetracycline, chlorotetracycline, bacitracin, neomycin, polymyxin, gramicidin, oxytetracycline, chloramphenicol, gentamycin, pencillin and erythromycin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-20 | 1979-04-21 | 1979-10-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-20 | 1983-04-21 | 1983-10-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-20 | 1987-04-21 | 1987-10-21 | $7700.00 | Window Closed / Lapsed |