Gradual release medicine carrier

Abstract

Abstract A medicament carried within a perforate or semipermeable shell is gradually released, as by dissolution into body fluids, to provide effective therapy with reduced concentration and dosage. The medicament may be in dry powdered form. For treatment of the eye, the carrier comprises a capsule less than 1 millimeter in diameter which is placed in the conjunctival sac or mounted in a contact lens. The capsule may be colored for easy location and removal, may be absorbable by the body, or may gradually swell to allow washout by the tears. For glaucoma treatment, less than 1 milligram of pilocarpine or phospholine in a single sustained release capsule may be an adequate daily dosage. In another embodiment a soft contact lens itself may serve as the medicine containing carrier. For burn, ulcer, or wound treatment, the carrier may be of planar configuration or incorporated in a film forming spray comprising many minute particles or capsules each containing a medicament. The resultant film will protect the tissue from exposure, will provide sustained release medication, and may be absorbable to eliminate the need for removal with concomitant damage to newly formed granulation tissue.

Inventors

• 👤 S Abraham

Bibliographic Details