Medicinal dosage forms of unpolymerized thiolated gelatin with a cross-linking accelerating agent providing slowly released medication from a swollen matrix
Abstract
Abstract A DRY SOLID MEDICINAL DOSAGE FORM COMPRISING A MEDICINAL AGENT, THE REACTION PRODUCT OF GELATIN WITH N-ACETYLHOMOCYSTEINE THIOLACTONE HAVING AN AVERAGE MOLECULAR WEIGHT OF FROM 10,000 TO 500,000 AND HAVING AN AVERAGE OF FROM ABOUT 3.5 TO ABOUT 30-SH EQUIVALENTS PER 100,000 GRAMS AND ACCELERATING AGENT (HARDENING OR SULFYDRYL CROSS-LINKING AGENT WHICH CAN BE A PHARMACOLOGICALLY ACCEPTABLE OXIDIZING AGENT OR BASE) AND ONE OR BOTH OF A NON-DIGESTIBLE HYDROPHILIC COLLOID AND A WATER SOLUBLE MINERAL ACID SALT. THE DOSAGE FORM CONTAINING THE REACTION PRODUCT OF GELATIN WITH N-ACETHLHOMOCYSTEINE THIOLACTONE IN THE UNPOLYMERIZED FORM, I.E., THE PRODUCT IS NOT CROSS-LINKED AND CONTAINS FREE SULFHYDROL GROUPS.
Inventors
- 👤 Richard H Johnson
- 👤 Englebert L Rowe
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-04-12 | 1974-10-12 | 1975-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-04-12 | 1978-10-12 | 1979-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-04-12 | 1982-10-12 | 1983-04-13 | $7700.00 | Window Closed / Lapsed |