Non-thrombogenic vascular prosthesis

Abstract

Abstract The invention provides vascular prostheses (10) free of any substance that counteracts an anti-coagulant comprising a base material having inner (16) and outer (14) surfaces, wherein the outer surface has a layer of a material capable of reducing the porosity of said prosthesis to blood or body fluid and a coating of compounded heparin (24) bound thereon, and the inner surface (16) has a coating of compounded heparin (24) bound thereon, the compounded heparin (24) comprising heparin and a cationic surfactant. The present invention also provides a method for forming a vascular prosthesis. The vascular prostheses (10) exhibit an initial low porosity thereby obviating the need for pre-clotting the prosthesis. The compounded heparin (24) coating of the vascular prostheses prevents or slows down blood clotting which leads to the build up of natural tissue within the interstitial spaces of the prosthesis (10) and the build-up of a thin, even, well-defined and well-adhered pseudo-intima on the inner surface of the prosthesis (10).

Inventors

• 👤 George L. De Goicoechea
• 👤 John O. Hudson

Bibliographic Details