Patent US6730016B1 successfully refreshed from Google Patents.
US6730016B1
Expired / Lapsed
US
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Cardiac disease treatment and device
Assignee: Mardil Inc
•
Filing: 2000-06-12
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Granted: 2004-05-04
•
Expires: 2020-06-12
Abstract
Abstract A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
Inventors
- 👤 James Cox
- 👤 Michael J. Girard
- 👤 II Donald F. Palme
- 👤 Donald G. Rohrbaugh
- 👤 Hani N. Sabbah
- 👤 II J. Edward Shapland
- 👤 Robert G. Walsh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:39
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2478; A61F2/2481; A61P; A61P9/00; A61P9/04; A61P9/06; D; D04; D04B; D04B21/00; D04B21/10; D04B21/12; D10; D10B; D10B2509/00; D10B2509/08; Y; Y10; Y10S; Y10S977/00; Y10S977/902; Y10S977/904; Y10S977/906; Y10S977/907
Claims Analysis
Total Claims: 48
Claim 1
Independent Claim
121 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent lining in association with the jacket wherein the non-adherent lining is provided in the form of one or more ribs extending from a base to an apex of the heart.
Claim 2
Independent Claim
121 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent lining in association with the jacket wherein the non-adherent lining is provided in the form of one or more ribs extending from a base to an apex of the heart.
Claim 3
Independent Claim
116 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; b. a non-adherent lining in association with the jacket; and c. a delivery source for the delivery of one or more therapeutic agents to the surface of the heart.
Claim 4
Independent Claim
116 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; b. a non-adherent lining in association with the jacket; and c. a delivery source for the delivery of one or more therapeutic agents to the surface of the heart.
Claim 5
Dependent Claim
29 words
The device according to claim 2 wherein the device provides localized delivery of the one or more therapeutic agents to a target area on the surface of the heart.
Claim 6
Dependent Claim
14 words
The device according to claim 2 wherein the therapeutic agent comprises a pharmacological agent.
Claim 7
Dependent Claim
13 words
The device according to claim 2 wherein the therapeutic agent comprises cellular material.
Claim 8
Dependent Claim
16 words
The device according to claim 2 wherein the delivery source comprises a coating on the jacket.
Claim 9
Dependent Claim
17 words
The device according to claim 2 wherein the delivery source comprises a separable element from the jacket.
Claim 10
Dependent Claim
35 words
The device according to claim 2 wherein the delivery source for the delivery of one or more therapeutic agents is provided at an area of the jacket that overlaps an area of the non-adherent material.
Claim 11
Dependent Claim
16 words
The device according to claim 8 wherein the non-adherent material is permeable to the therapeutic agent(s).
Claim 12
Dependent Claim
37 words
The device according to claim 2 wherein the delivery source for the delivery of one or more therapeutic agents is provided at an area of the jacket that is separate from an area of the non-adherent material.
Claim 13
Independent Claim
146 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and 2) a non-adherent lining in association with the jacket, wherein the non-adherent lining is provided in the form of one or more ribs extending from a base to an apex of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 14
Independent Claim
146 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and 2) a non-adherent lining in association with the jacket, wherein the non-adherent lining is provided in the form of one or more ribs extending from a base to an apex of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 15
Independent Claim
135 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between at upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; 2) a non-adherent lining; and 3) a delivery source for delivery of one or more therapeutic agents to the surface of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 16
Independent Claim
135 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between at upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; 2) a non-adherent lining; and 3) a delivery source for delivery of one or more therapeutic agents to the surface of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 17
Dependent Claim
20 words
The method according to claim 12 , wherein the one or more therapeutic agents comprise one or more pharmacological agents.
Claim 18
Dependent Claim
16 words
The method according to claim 12 wherein the one or more therapeutic agents comprise cellular material.
Claim 19
Independent Claim
111 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent coating in association with the jacket, wherein the non-adherent coating is configured to cover only selected areas of the heart.
Claim 20
Independent Claim
111 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent coating in association with the jacket, wherein the non-adherent coating is configured to cover only selected areas of the heart.
Claim 21
Dependent Claim
13 words
The device according to claim 15 wherein the jacket comprises an elastic material.
Claim 22
Dependent Claim
15 words
The device according to claim 15 , wherein the jacket comprises an open cell material.
Claim 23
Independent Claim
123 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket comprised of an open cell flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent coating in association with the jacket wherein the open cell material defines interstitial spaces and the non-adherent coating fills the interstitial spaces defined by the open cell material.
Claim 24
Independent Claim
123 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket comprised of an open cell flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent coating in association with the jacket wherein the open cell material defines interstitial spaces and the non-adherent coating fills the interstitial spaces defined by the open cell material.
Claim 25
Independent Claim
103 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole, the jacket comprising a biodegradable material; and b. a non-adherent coating in association with the jacket.
Claim 26
Independent Claim
103 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole, the jacket comprising a biodegradable material; and b. a non-adherent coating in association with the jacket.
Claim 27
Independent Claim
120 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent coating in association with the jacket, wherein the non-adherent material provided in the form of one or more ribs extending from a base to an apex of the heart.
Claim 28
Independent Claim
120 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and b. a non-adherent coating in association with the jacket, wherein the non-adherent material provided in the form of one or more ribs extending from a base to an apex of the heart.
Claim 29
Independent Claim
116 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; b. a non-adherent coating in association with the jacket; and c. a delivery source for the delivery of one or more therapeutic agents to the surface of the heart.
Claim 30
Independent Claim
116 words
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising: a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; b. a non-adherent coating in association with the jacket; and c. a delivery source for the delivery of one or more therapeutic agents to the surface of the heart.
Claim 31
Dependent Claim
29 words
The device according to claim 21 wherein the device provides localized delivery of the one or more therapeutic agents to a target area on the surface of the heart.
Claim 32
Dependent Claim
14 words
The device according to claim 21 wherein the therapeutic agent comprises a pharmacological agent.
Claim 33
Dependent Claim
13 words
The device according to claim 21 wherein the therapeutic agent comprises cellular material.
Claim 34
Dependent Claim
15 words
The device according to claim 21 the delivery source comprises a coating on the jacket.
Claim 35
Dependent Claim
17 words
The device according to claim 21 wherein the delivery source comprises a separable element from the jacket.
Claim 36
Dependent Claim
35 words
The device according to claim 21 wherein the delivery source for the delivery of one or more therapeutic agents is provided at an area of the jacket that overlaps an area of the non-adherent material.
Claim 37
Dependent Claim
16 words
The device according to claim 21 wherein the non-adherent material is permeable to the therapeutic agent(s).
Claim 38
Dependent Claim
37 words
The device according to claim 21 wherein the delivery source for the delivery of one or more therapeutic agents is provided at an area of the jacket that is separate from an area of the non-adherent material.
Claim 39
Independent Claim
136 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and 2) a non-adherent coating in association with the jacket, wherein the non-adherent coating is configured to contact only selected areas of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 40
Independent Claim
136 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and 2) a non-adherent coating in association with the jacket, wherein the non-adherent coating is configured to contact only selected areas of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 41
Independent Claim
146 words
A method for treating cardiac disease, the method comprising: a surgically accessing the heart; b. applying a treatment device oil the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and 2), a non-adherent coating in association with the jacket, wherein the non-adherent material is provided in the form of one or more ribs extending from a base to an apex of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 42
Independent Claim
146 words
A method for treating cardiac disease, the method comprising: a surgically accessing the heart; b. applying a treatment device oil the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; and 2), a non-adherent coating in association with the jacket, wherein the non-adherent material is provided in the form of one or more ribs extending from a base to an apex of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 43
Independent Claim
140 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; 2) a non-adherent coating in association with the jacket; and 3) a delivery source for delivery of one or more therapeutic agents to the surface of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 44
Independent Claim
140 words
A method for treating cardiac disease, the method comprising: a. surgically accessing the heart; b. applying a treatment device on the heart, the device comprising: 1) a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart to constrain circumferential expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole; 2) a non-adherent coating in association with the jacket; and 3) a delivery source for delivery of one or more therapeutic agents to the surface of the heart; c. securing the treatment device to the heart; and d. surgically closing access to the heart while leaving the treatment device on the heart.
Claim 45
Dependent Claim
20 words
The method according to claim 31 , wherein the one or more therapeutic agents comprise one or more pharmacological agents.
Claim 46
Dependent Claim
16 words
The method according to claim 31 wherein the one or more therapeutic agents comprise cellular material.
Claim 47
Dependent Claim
15 words
The device according to claim 31 , wherein the jacket comprises an open cell material.
Claim 48
Dependent Claim
29 words
The device according to claim 35 , wherein the open cell material defines interstitial spaces and the non-adherent coating fills the interstitial spaces defined by the open cell material.
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