US6692563B2
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Magnesium-ammonium-phosphates cements, the production of the same and the use thereof
Assignee: Medtronic Europe SARL
•
Filing: 2001-07-03
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Granted: 2004-02-17
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Expires: 2021-07-03
Abstract
Abstract This invention relates to a cement, which consists in its main phase of microcrystalline magnesium ammonium phosphate and nanoapatite after hardening and thus at the same time has considerable strength.The material is biologically degradable and is suitable for application in tooth cements, as bone replacement, as bone filler, as bone cement or as bone adhesive.
Inventors
- 👤 Michael Zimmermann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:36
CPC Classifications
C; C04; C04B; C04B28/00; C04B28/34; A; A61; A61K; A61K33/00; A61K33/06; A61K33/42; A61K45/00; A61K45/06; A61K6/00; A61K6/15; A61K6/17; A61K6/80; A61K6/831; A61K6/838; A61K6/849; A61K6/864; A61K6/867; A61L; A61L24/00; A61L24/001; A61L24/0036; A61L24/02; A61L27/00; A61L27/02; A61L27/12; A61L27/50; A61L27/56; A61P; A61P19/00; C04B28/344; C04B28/346; C04B28/348; A61B; A61B17/00; A61B17/00491; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30316; A61F2002/30535; A61F2/46; A61F2002/4631; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0058; A61L2430/00; A61L2430/02; C04B2103/00; C04B2103/0004; C04B2103/0006; C04B2103/0009; C04B2111/00; C04B2111/00034; C04B2111/00206; C04B2111/00474; C04B2111/00836
Claims Analysis
Total Claims: 82
Claim 1
Independent Claim
41 words
A magnesium ammonium phosphate cement preparation comprising a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; an ammonium salt; and water or an aqueous solution.
Claim 2
Dependent Claim
41 words
A magnesium ammonium phosphate cement preparation comprising a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; an ammonium salt; and water or an aqueous solution.
Claim 3
Dependent Claim
28 words
The preparation according to claim 1 , wherein the aqueous solution comprises an aqueous solution of an ammonium salt having a pH value in the range from 7<pH<12.
Claim 4
Dependent Claim
35 words
The preparation according to claim 1 , wherein the ammonium salt is present in the powder mixture and the molar quantity of the component ammonium (NH 4 ) lies in the range 0<NH 4 <0.50.
Claim 5
Dependent Claim
18 words
A preparation according to one of claim 1 , wherein the powder mixture comprises α/β-tertiary calcium phosphate (α/β-TCP).
Claim 6
Dependent Claim
18 words
A preparation according to claim 4 , wherein the powder mixture further comprises MgHPO 4 .3H 2 O.
Claim 7
Dependent Claim
20 words
The preparation according to claim 5 , wherein the powder mixture further comprises Mg 3 (PO 4 ) 2 .
Claim 8
Dependent Claim
21 words
The preparation according to claim 1 , wherein the aqueous solution comprises an aqueous (NH 4 ) 2 SO 4 solution.
Claim 9
Dependent Claim
19 words
The preparation according to claim 1 , wherein the powder mixture comprises (NH 4 ) 2 SO 4 .
Claim 10
Dependent Claim
21 words
The preparation according to claim 1 , wherein the aqueous solution comprises an aqueous (NH 4 ) 2 HPO 4 solution.
Claim 11
Dependent Claim
18 words
The preparation according to claim 1 , wherein the powder mixture further comprises KH 2 PO 4 .
Claim 12
Dependent Claim
18 words
The preparation according to claim 1 , wherein the powder mixture further comprises Na 2 HPO 4 .
Claim 13
Dependent Claim
12 words
The preparation according to claim 1 , further comprising SrCO 3 .
Claim 14
Dependent Claim
29 words
The preparation according to claim 12 , wherein the SrCO 3 is in the range of 0 to 10 wt. % based on the total weight of the preparation.
Claim 15
Dependent Claim
15 words
The preparation according to claim 13 , comprising an aqueous solution of an ammonium salt.
Claim 16
Dependent Claim
29 words
The preparation according to claim 12 , wherein the SrCO 3 is in the range of 0.1 to 5 wt. % based on the total weight of the preparation.
Claim 17
Dependent Claim
15 words
The preparation according to claim 15 , comprising an aqueous solution of an ammonium salt.
Claim 18
Dependent Claim
19 words
The preparation according to claim 1 , wherein the aqueous solution comprises an aqueous solution of a strontium salt.
Claim 19
Dependent Claim
10 words
The preparation according to claim 1 , further comprising ZnO.
Claim 20
Dependent Claim
23 words
The preparation according to claim 1 , wherein the powder mixture further comprises Ca 2 NaK(PO 4 ) 2 and/or CaKPO 4 .
Claim 21
Dependent Claim
11 words
The preparation according to claim 1 , further comprising a fluoride.
Claim 22
Dependent Claim
16 words
The preparation according to claim 1 , further comprising a pharmaceutical and/or a bioactive active ingredient.
Claim 23
Dependent Claim
39 words
The preparation according to claim 21 , wherein the pharmaceutical and/or a bioactive active ingredient comprises a therapeutic dose of a component selected from the group consisting of antibiotics, cytostatic agents, analgesics, disinfectants, growth factors, proteins or elastin inhibitors.
Claim 24
Dependent Claim
38 words
A magnesium ammonium phosphate cement preparation comprising: a powder mixture comprising α-TCP, β-TCP, MgHPO 4 .3 H 2 O, KH 2 PO 4 and Na 2 HPO 4 ; an ammonium salt; and water or an aqueous solution.
Claim 25
Dependent Claim
38 words
A magnesium ammonium phosphate cement preparation comprising: a powder mixture comprising α-TCP, β-TCP, MgHPO 4 .3 H 2 O, KH 2 PO 4 and Na 2 HPO 4 ; an ammonium salt; and water or an aqueous solution.
Claim 26
Dependent Claim
16 words
The preparation according to claim 23 , wherein the powder mixture further comprises SrCO 3 .
Claim 27
Dependent Claim
30 words
The preparation according to claim 24 , wherein the SrCO 3 is present in a quantity of 0.01 to 10 wt. % based on the total weight of the preparation.
Claim 28
Dependent Claim
19 words
The preparation according to claim 23 , wherein the aqueous solution comprises an aqueous solution of a strontium salt.
Claim 29
Dependent Claim
10 words
The preparation according to claim 23 , further comprising ZnO.
Claim 30
Dependent Claim
23 words
The preparation according to claim 23 , wherein the powder mixture further comprises Ca 2 NaK(PO 4 ) 2 and/or CaKPO 4 .
Claim 31
Dependent Claim
11 words
The preparation according to claim 23 , further comprising a fluoride.
Claim 32
Dependent Claim
16 words
The preparation according to claim 23 , further comprising a pharmaceutical and/or a bioactive active ingredient.
Claim 33
Dependent Claim
39 words
The preparation according to claim 30 , wherein the pharmaceutical and/or a bioactive active ingredient comprises a therapeutic dose of a component selected from the group consisting of antibiotics, cytostatic agents, analgesics, disinfectants, growth factors, proteins or elastin inhibitors.
Claim 34
Dependent Claim
40 words
A magnesium ammonium phosphate cement preparation comprising an aqueous solution containing ammonium ions and a powder mixture comprising α/β-TCP, MgHPO 4 ×3H 2 O, KH 2 PO 4 Na 2 HPO 4 and Mg 3 (PO 4 ) 2 .
Claim 35
Dependent Claim
40 words
A magnesium ammonium phosphate cement preparation comprising an aqueous solution containing ammonium ions and a powder mixture comprising α/β-TCP, MgHPO 4 ×3H 2 O, KH 2 PO 4 Na 2 HPO 4 and Mg 3 (PO 4 ) 2 .
Claim 36
Dependent Claim
16 words
The preparation according to claim 32 , wherein the powder mixture further comprises SrCO 3 .
Claim 37
Dependent Claim
30 words
The preparation according to claim 33 , wherein the SrCO 3 is present in a quantity of 0.01 to 10 wt. % based on the total weight of the preparation.
Claim 38
Dependent Claim
19 words
The preparation according to claim 32 , wherein the aqueous solution comprises an aqueous solution of a strontium salt.
Claim 39
Dependent Claim
10 words
The preparation according to claim 32 , further comprising ZnO.
Claim 40
Dependent Claim
23 words
The preparation according to claim 32 , wherein the powder mixture further comprises Ca 2 NaK(PO 4 ) 2 and/or CaKPO 4 .
Claim 41
Dependent Claim
11 words
The preparation according to claim 32 , further comprising a fluoride.
Claim 42
Dependent Claim
16 words
The preparation according to claim 32 , further comprising a pharmaceutical and/or a bioactive active ingredient.
Claim 43
Dependent Claim
39 words
The preparation according to claim 39 , wherein the pharmaceutical and/or a bioactive active ingredient comprises a therapeutic dose of a component selected from the group consisting of antibiotics, cytostatic agents, analgesics, disinfectants, growth factors, proteins or elastin inhibitors.
Claim 44
Dependent Claim
39 words
A magnesium ammonium phosphate cement preparation comprising: a powder mixture comprising α-TCP, β-TCP, (NH 4 ) 2 SO 4 , KH 2 PO 4 and Na 2 HPO 4 ; a magnesium salt; and water or an aqueous solution.
Claim 45
Dependent Claim
39 words
A magnesium ammonium phosphate cement preparation comprising: a powder mixture comprising α-TCP, β-TCP, (NH 4 ) 2 SO 4 , KH 2 PO 4 and Na 2 HPO 4 ; a magnesium salt; and water or an aqueous solution.
Claim 46
Dependent Claim
17 words
The preparation according to claim 41 , wherein the magnesium salt is MgHPO 4 .3H 2 O.
Claim 47
Dependent Claim
16 words
The preparation according to claim 41 , wherein the powder mixture further comprises SrCO 3 .
Claim 48
Dependent Claim
30 words
The preparation according to claim 43 , wherein the SrCO 3 is present in a quantity of 0.01 to 10 wt. % based on the total weight of the preparation.
Claim 49
Dependent Claim
19 words
The preparation according to claim 41 , wherein the aqueous solution comprises an aqueous solution of a magnesium salt.
Claim 50
Dependent Claim
19 words
The preparation according to claim 41 , wherein the aqueous solution comprises an aqueous solution of a strontium salt.
Claim 51
Dependent Claim
10 words
The preparation according to claim 41 , further comprising ZnO.
Claim 52
Dependent Claim
23 words
The preparation according to claim 41 , wherein the powder mixture further comprises Ca 2 NaK(PO 4 ) 2 and/or CaKPO 4 .
Claim 53
Dependent Claim
11 words
The preparation according to claim 41 , further comprising a fluoride.
Claim 54
Dependent Claim
16 words
The preparation according to claim 41 , further comprising a pharmaceutical and/or a bioactive active ingredient.
Claim 55
Dependent Claim
39 words
The preparation according to claim 50 , wherein the pharmaceutical and/or a bioactive active ingredient comprises a therapeutic dose of a component selected from the group consisting of antibiotics, cytostatic agents, analgesics, disinfectants, growth factors, proteins or elastin inhibitors.
Claim 56
Dependent Claim
37 words
A magnesium ammonium phosphate cement preparation comprising: a powder mixture comprising α-TCP, β-TCP, primary or secondary ammonium phosphate, KH 2 PO 4 and Na 2 HPO 4 ; a magnesium salt; and water or an aqueous solution.
Claim 57
Dependent Claim
37 words
A magnesium ammonium phosphate cement preparation comprising: a powder mixture comprising α-TCP, β-TCP, primary or secondary ammonium phosphate, KH 2 PO 4 and Na 2 HPO 4 ; a magnesium salt; and water or an aqueous solution.
Claim 58
Dependent Claim
18 words
The preparation according to claim 52 , wherein the magnesium salt is MgHPO 4 .3 H 2 O.
Claim 59
Dependent Claim
16 words
The preparation according to claim 52 , wherein the powder mixture further comprises SrCO 3 .
Claim 60
Dependent Claim
30 words
The preparation according to claim 54 , wherein the SrCO 3 is present in a quantity of 0.01 to 10 wt. % based on the total weight of the preparation.
Claim 61
Dependent Claim
19 words
The preparation according to claim 52 , wherein the aqueous solution comprises an aqueous solution of a strontium salt.
Claim 62
Dependent Claim
10 words
The preparation according to claim 52 , further comprising ZnO.
Claim 63
Dependent Claim
23 words
The preparation according to claim 52 , wherein the powder mixture further comprises Ca 2 NaK(PO 4 ) 2 and/or CaKPO 4 .
Claim 64
Dependent Claim
11 words
The preparation according to claim 52 , further comprising a fluoride.
Claim 65
Dependent Claim
16 words
The preparation according to claim 52 , further comprising a pharmaceutical and/or a bioactive active ingredient.
Claim 66
Dependent Claim
39 words
The preparation according to claim 60 , wherein the pharmaceutical and/or a bioactive active ingredient comprises a therapeutic dose of a component selected from the group consisting of antibiotics, cytostatic agents, analgesics, disinfectants, growth factors, proteins or elastin inhibitors.
Claim 67
Dependent Claim
86 words
A process for producing a magnesium ammonium phosphate cement, the process comprising: providing an ammonium salt; providing a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; mixing the ammonium salt and the powder mixture with a mixing liquid to form a paste and achieve an uniform distribution of the liquid in the powder mixture; and hardening the paste and reacting the components therein to form a microcrystalline magnesium ammonium phosphate.
Claim 68
Dependent Claim
86 words
A process for producing a magnesium ammonium phosphate cement, the process comprising: providing an ammonium salt; providing a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; mixing the ammonium salt and the powder mixture with a mixing liquid to form a paste and achieve an uniform distribution of the liquid in the powder mixture; and hardening the paste and reacting the components therein to form a microcrystalline magnesium ammonium phosphate.
Claim 69
Dependent Claim
29 words
The process according to claim 62 , wherein the ammonium salt is provided in an aqueous solution and the mixing liquid comprises the aqueous solution of the ammonium salt.
Claim 70
Dependent Claim
35 words
The process according to claim 62 , further comprising providing the powder mixture with granular particles, which are slightly soluble in aqueous liquids, having a particle size between about 10 μm and about 300 μm.
Claim 71
Dependent Claim
18 words
The process according to claim 64 , wherein the granular particles are between 50 μm and 200 μm.
Claim 72
Dependent Claim
34 words
The process according to claim 64 , further comprising selecting the granular particles from the group consisting of NaCl, sugars, CaSO 4 , β-TCP, polylactides, polyglycolides, polylactide/polyglycolide copolymers, CaCO 3 and CaHPO 4 .
Claim 73
Dependent Claim
82 words
A process for producing a magnesium ammonium phosphate cement, the process comprising: providing an ammonium salt; providing a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; mixing the ammonium salt and the powder mixture with a mixing liquid to form a paste and achieve an uniform distribution of the liquid in the powder mixture; and hardening the paste with formation of a microcrystalline magnesium ammonium phosphate.
Claim 74
Dependent Claim
82 words
A process for producing a magnesium ammonium phosphate cement, the process comprising: providing an ammonium salt; providing a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; mixing the ammonium salt and the powder mixture with a mixing liquid to form a paste and achieve an uniform distribution of the liquid in the powder mixture; and hardening the paste with formation of a microcrystalline magnesium ammonium phosphate.
Claim 75
Dependent Claim
29 words
The process according to claim 67 , wherein the ammonium salt is provided in an aqueous solution and the mixing liquid comprises the aqueous solution of the ammonium salt.
Claim 76
Dependent Claim
35 words
The process according to claim 67 , further comprising providing the powder mixture with granular particles, which are slightly soluble in aqueous liquids, having a particle size between about 10 μm and about 300 μm.
Claim 77
Dependent Claim
18 words
The process according to claim 69 , wherein the granular particles are between 50 μm and 200 μm.
Claim 78
Dependent Claim
34 words
The process according to claim 69 , further comprising selecting the granular particles from the group consisting of NaCl, sugars, CaSO 4 , β-TCP, polylactides, polyglycolides, polylactide/polyglycolide copolymers, CaCO 3 and CaHPO 4 .
Claim 79
Independent Claim
63 words
A method for dentine or endodontology repair in a patient site, said method comprising applying a hardenable magnesium phosphate cement preparation to the patient site, wherein the preparation comprises: a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; an ammonium salt; and water or an aqueous solution.
Claim 80
Independent Claim
63 words
A method for dentine or endodontology repair in a patient site, said method comprising applying a hardenable magnesium phosphate cement preparation to the patient site, wherein the preparation comprises: a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; an ammonium salt; and water or an aqueous solution.
Claim 81
Independent Claim
63 words
A method for bone replacement or repair in a patient site, said method comprising applying a hardenable magnesium phosphate cement preparation to the patient site, wherein the preparation comprises: a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; an ammonium salt; and water or an aqueous solution.
Claim 82
Independent Claim
63 words
A method for bone replacement or repair in a patient site, said method comprising applying a hardenable magnesium phosphate cement preparation to the patient site, wherein the preparation comprises: a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; an ammonium salt; and water or an aqueous solution.
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