US5952010A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Paste compositions capable of setting into carbonated apatite
Assignee: Norian Corp
•
Filing: 1997-12-09
•
Granted: 1999-09-14
•
Expires: 2017-12-09
Abstract
Abstract Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest
Inventors
- 👤 Brent R. Constantz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:34
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/02; A61K; A61K6/00; A61K6/60; A61K6/69; A61K6/70; A61K6/71; A61K6/74; A61K6/75; A61L27/00; A61L27/02; A61L27/12; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/58; C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; C01B25/322; C01B25/327; C01B25/455; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2817; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2210/00; A61F2210/0004; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
97 words
A paste composition capable of hardening in about 5 to 20 minutes into an integral mass of substantially pure carbonate substituted hydroxyapatite, wherein said integral mass comprises from about 2 to 10% by weight carbonate and a calcium/phosphate ratio in the range of about 1.33 to 2.0 and has a compressive strength ranging from about 5620 to 11794 psi, wherein said paste composition is prepared by mixing: dry ingredients comprising at least one calcium source, a partially neutralized phosphoric acid source free of uncombined water, and a carbonate source; with a lubricant to produce said pasete composition.
Claim 2
Dependent Claim
97 words
A paste composition capable of hardening in about 5 to 20 minutes into an integral mass of substantially pure carbonate substituted hydroxyapatite, wherein said integral mass comprises from about 2 to 10% by weight carbonate and a calcium/phosphate ratio in the range of about 1.33 to 2.0 and has a compressive strength ranging from about 5620 to 11794 psi, wherein said paste composition is prepared by mixing: dry ingredients comprising at least one calcium source, a partially neutralized phosphoric acid source free of uncombined water, and a carbonate source; with a lubricant to produce said pasete composition.
Claim 3
Dependent Claim
36 words
The paste composition according to claim 1, wherein said integral mass comprises from about 2.5 and 7% carbonate by weight and a calcium/phosphate ratio of more than 1.5 and less than or equal to about 2.0.
Claim 4
Dependent Claim
23 words
The paste composition according to claim 2, wherein said lubricant is an aqueous lubricant having a pH in the range of about 6-11.
Claim 5
Dependent Claim
25 words
The paste composition according to claim 2, wherein said lubricant is present in from about 15 to 50 weight % of the total paste composition.
Claim 6
Dependent Claim
16 words
The paste composition according to claim 2, wherein said lubricant contains sodium phosphate, carbonate or hydroxide.
Claim 7
Dependent Claim
25 words
The paste composition according to claim 5, wherein the concentration of sodium phosphate, carbonate or hydroxide in said lubricant ranges from about 0.01 to 2M.
Claim 8
Dependent Claim
96 words
A paste composition capable of hardening in about 5 to 20 minutes into an integral mass of substantially pure carbonate substituted hydroxyapatite, wherein said integral mass comprises from about 2 to 10% by weight carbonate and a calcium/phosphate ratio in the range of about 1.33 to 2.0 and has a compressive strength ranging from about 5620 to 11794 psi, wherein said composition is prepared by the method comprising: mechanically mixing at least one calcium source, a partially neutralized phosphoric acid source free of uncombined water, and a carbonate source with a lubricant to produce said composition.
Claim 9
Dependent Claim
96 words
A paste composition capable of hardening in about 5 to 20 minutes into an integral mass of substantially pure carbonate substituted hydroxyapatite, wherein said integral mass comprises from about 2 to 10% by weight carbonate and a calcium/phosphate ratio in the range of about 1.33 to 2.0 and has a compressive strength ranging from about 5620 to 11794 psi, wherein said composition is prepared by the method comprising: mechanically mixing at least one calcium source, a partially neutralized phosphoric acid source free of uncombined water, and a carbonate source with a lubricant to produce said composition.
Claim 10
Dependent Claim
28 words
The paste composition according to claim 7, wherein said integral mass comprises from about 2.5 and 7% carbonate by weight and a calcium/phosphate ratio of more than 1.5.
Claim 11
Dependent Claim
23 words
The paste composition according to claim 8, wherein said lubricant is an aqueous lubricant having a pH in the range of about 6-11.
Claim 12
Dependent Claim
25 words
The paste composition according to claim 9, wherein said lubricant is present in from about 15 to 50 weight % of the total paste composition.
Claim 13
Dependent Claim
17 words
The paste composition according to claim 10, wherein said aqueous lubricant contains sodium phosphate, carbonate or hydroxide.
Claim 14
Dependent Claim
25 words
The paste composition according to claim 11, wherein the concentration of sodium phosphate, carbonate or hydroxide in said lubricant ranges from about 0.01 to 2M.
References Cited (Backward Citations)
US33121A
Cited
US33161A
Cited
US4139599A
Cited
US3913229A
Cited
US4170658A
Cited
US4321042A
Cited
US4097935A
Cited
US4279661A
Cited
US4429691A
Cited
USRE33121E
Cited
US4481174A
Cited
USRE33161E
Cited
US4917702A
Cited
US4959104A
Cited
US5178845A
Cited
US5336264A
Cited
JPH03174349A
Cited
US5569490A
Cited
US5152836A
Cited
US5322675A
Cited
US5149368A
Cited
JPH04348754A
Cited
JPH04348755A
Cited
JPH059383A
Cited
JPH0523386A
Cited
US5338356A
Cited
US5320844A
Cited
JPH05319891A
Cited
JPH0645494A
Cited
EP0639366A1
Cited
WO1995008304A1
Cited
US5525148A
Cited
CA2143733A1
Cited
US5571493A
Cited
US5676976A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-09-13 | 2003-03-15 | 2003-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-09-13 | 2007-03-15 | 2007-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-09-13 | 2011-03-15 | 2011-09-14 | $7700.00 | Window Closed / Lapsed |