Patent US6572578B1 successfully refreshed from Google Patents.
US6572578B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluid-jet catheter and its application to flexible endoscopy
Assignee: Individual
•
Filing: 2000-08-25
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Granted: 2003-06-03
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Expires: 2020-08-25
Abstract
Abstract Fluid jet tubes having operative openings and cell traps for cell cluster, tissue and debris harvesting and collecting are used with an endoscope such that the fluid jets draw-in, stabilize and hold in-vivo target specimens at a distal end. While the catheter grips the tissue by suction, blasts of high pressure solution strip from the tissue and suspend clusters of cells which are ready for analysis. The clusters are entrained in the solution and are recovered in a cell collection trap at the proximal end. Traps are removed, replaced or rotated out of and into alignment with a trap connector to accommodate new target specimens. A switch controls fluid flow, intensity and frequency of fluid jet blasts of the solution. The fluid jet catheter paired with a fiber optic system in an endoscope allows viewing of areas surrounding the distal end of the catheter.
Inventors
- 👤 Patrick A. Blanchard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:16
CPC Classifications
A; A61; A61B; A61B10/00; A61B10/02; A61B10/0233; A61B10/0266; A61B10/04; A61B17/00; A61B17/32; A61B17/3203; A61B17/32037
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
93 words
Sample collection apparatus comprising a catheter having a proximal and a distal end, a pressure tube connected to the catheter and extending from the proximal to the distal end of the catheter, a cell recovery tube connected to the catheter and extending from the proximal to the distal end of the catheter, and a cell cluster trap connected to the cell recovery tube at the proximal end of the catheter for obtaining, dissecting and storing dissected tissue samples from targeted tissue within a body and conveying the dissected tissue samples from the body.
Claim 2
Dependent Claim
93 words
Sample collection apparatus comprising a catheter having a proximal and a distal end, a pressure tube connected to the catheter and extending from the proximal to the distal end of the catheter, a cell recovery tube connected to the catheter and extending from the proximal to the distal end of the catheter, and a cell cluster trap connected to the cell recovery tube at the proximal end of the catheter for obtaining, dissecting and storing dissected tissue samples from targeted tissue within a body and conveying the dissected tissue samples from the body.
Claim 3
Dependent Claim
43 words
The apparatus of claim 1 , further comprising an operator connected at the proximal end of the catheter and a flow reverser connected to at least one of the pressure tube and the cell recovery tube at a distal end of the catheter.
Claim 4
Dependent Claim
12 words
The apparatus of claim 2 , wherein the operator is a handpiece.
Claim 5
Dependent Claim
19 words
The apparatus of claim 3 , further comprising a connector for connecting the cell cluster trap to the handpiece.
Claim 6
Dependent Claim
31 words
The apparatus of claim 1 , further comprising a chamber with a lateral aperture connected between the pressure tube and the cell recovery tube at the distal end of the catheter.
Claim 7
Dependent Claim
36 words
The apparatus of claim 5 , further comprising a flow reverser connected to the chamber and to at least one of the pressure tube and the cell recovery tube at a distal end of the catheter.
Claim 8
Dependent Claim
28 words
The apparatus of claim 6 , wherein the flow reverser is connected to the chamber and the pressure tube at a distal end of the cell recovery tube.
Claim 9
Dependent Claim
18 words
The apparatus of claim 1 , wherein the cell cluster trap is detachable from the cell recovery tube.
Claim 10
Dependent Claim
20 words
The apparatus of claim 1 , further comprising plural cell cluster traps for sequentially attaching and removing from the catheter.
Claim 11
Dependent Claim
41 words
The apparatus of claim 1 , further comprising an endoscope having a proximal end and a distal end and having a lumen extending from the proximal end to the distal end of the endoscope for receiving the catheter in the lumen.
Claim 12
Dependent Claim
57 words
The apparatus of claim 10 , further comprising optical fibers disposed in the endoscope and extending from the proximal end to the distal end of the endoscope, a light source connected to at least one of the optical fibers at the proximal end of the endoscope for illuminating a body at the distal end of the endoscope.
Claim 13
Dependent Claim
34 words
The apparatus of claim 11 , further comprising a viewing screen connected to at least on of the optical fibers for projecting an image of a view surrounding the distal end of the catheter.
Claim 14
Dependent Claim
81 words
The apparatus of claim 12 , further comprising a pressure source connected to a proximal end of the pressure tube, a suction source connected to a proximal end of the cell recovery tube, a power source connected to the pressure source and the suction source and a foot switch control connected to the power source for starting the sources and then intensifying the sources when a tissue to be sampled is adjacent the distal end as seen in the viewing screen.
Claim 15
Dependent Claim
163 words
Sample collecting apparatus comprising a catheter tube, a pressure tube within the catheter tube, a pump connected to the pressure tube for pumping saline solution through the pressure tube, a saline solution source connected to the pump, an end piece having a flow reverser attached to a distal end of the catheter tube for redirecting flow of saline solution and having a lateral opening for attracting the targeted tissue into the lateral opening and for dissecting clusters of cells from the targeted tissue, a cell recovery tube connected to the end piece for transporting the dissected clusters of cells, a cell cluster trap connected to a proximal end of the cell recovery tube for collecting and storing the clusters of cells, a controller connected to the pump for controlling actuation of the pump, and a power supply connected to the pump and to the controller for supplying power to the pump for obtaining, dissecting and storing clusters of cells from within a body.
Claim 16
Dependent Claim
163 words
Sample collecting apparatus comprising a catheter tube, a pressure tube within the catheter tube, a pump connected to the pressure tube for pumping saline solution through the pressure tube, a saline solution source connected to the pump, an end piece having a flow reverser attached to a distal end of the catheter tube for redirecting flow of saline solution and having a lateral opening for attracting the targeted tissue into the lateral opening and for dissecting clusters of cells from the targeted tissue, a cell recovery tube connected to the end piece for transporting the dissected clusters of cells, a cell cluster trap connected to a proximal end of the cell recovery tube for collecting and storing the clusters of cells, a controller connected to the pump for controlling actuation of the pump, and a power supply connected to the pump and to the controller for supplying power to the pump for obtaining, dissecting and storing clusters of cells from within a body.
Claim 17
Dependent Claim
22 words
The apparatus of claim 14 , further comprising a foot switch connected to the controller for governing the actuation of the controller.
Claim 18
Dependent Claim
34 words
The apparatus of claim 14 , further comprising an opening connected between the lateral opening and the cell recovery tube for directing saline solution and the clusters of cells into the cell recovery tube.
Claim 19
Dependent Claim
31 words
The apparatus of claim 14 , further comprising a connecting means connecting the cell recovery tube to the cell cluster trap for facilitating removal and replacement of the cell cluster trap.
Claim 20
Dependent Claim
68 words
A sample collection method comprising obtaining, dissecting and storing clusters of cells from targeted tissue by inserting a catheter in a body, transmitting fluid pressure through the catheter, drawing tissue partially into a chamber and partially dissecting the tissue and forming clusters of cells, entraining the clusters of cells through the catheter to a cell cluster trap and storing the clusters of cells in the cell cluster trap.
Claim 21
Dependent Claim
68 words
A sample collection method comprising obtaining, dissecting and storing clusters of cells from targeted tissue by inserting a catheter in a body, transmitting fluid pressure through the catheter, drawing tissue partially into a chamber and partially dissecting the tissue and forming clusters of cells, entraining the clusters of cells through the catheter to a cell cluster trap and storing the clusters of cells in the cell cluster trap.
Claim 22
Dependent Claim
28 words
The method of claim 18 , wherein the transmitting fluid pressure further comprises adjusting pulsation frequency, pressure, spray pattern, fluid composition and flow rate of a saline solution.
Claim 23
Dependent Claim
19 words
The method of claim 18 , further comprising using a foot switch to govern the actuation of the controller.
Claim 24
Dependent Claim
22 words
The method of claim 18 , wherein the applying fluid pressure comprises pumping a saline solution at pressures up to 20,000 psi.
Claim 25
Dependent Claim
19 words
The method of claim 18 , wherein the inserting a catheter in a body is controlled by a human.
Claim 26
Dependent Claim
19 words
The method of claim 18 , wherein the inserting a catheter in a body is controlled by a machine.
Claim 27
Dependent Claim
16 words
The method of claim 18 , further comprising contacting the clusters of cells with a cytopreservative.
Claim 28
Dependent Claim
16 words
The method of claim 18 , further comprising sequentially removing and replacing the cell cluster trap.
Claim 29
Dependent Claim
142 words
Diagnostic or therapeutic fluid jet applicator apparatus comprising a tubular structure having distal and proximal ends first and second lumens extending between the ends of the tubular structure, the first and second lumens having proximal ends near the proximal end of the tubular structure and having distal ends near the distal end of the tubular structure, an operative opening between the lumens at the distal end of the tubular structure, a pressure source connection at the proximal end of the tubular structure for connecting the pressure source to the proximal end of the first lumen, a cell trap connection at the proximal end of the tubular structure for connecting a cell trap to the proximal end of the second lumen, a drain connection at the proximal end of the tubular structure for removing fluids from the proximal end of the second lumen.
Claim 30
Dependent Claim
142 words
Diagnostic or therapeutic fluid jet applicator apparatus comprising a tubular structure having distal and proximal ends first and second lumens extending between the ends of the tubular structure, the first and second lumens having proximal ends near the proximal end of the tubular structure and having distal ends near the distal end of the tubular structure, an operative opening between the lumens at the distal end of the tubular structure, a pressure source connection at the proximal end of the tubular structure for connecting the pressure source to the proximal end of the first lumen, a cell trap connection at the proximal end of the tubular structure for connecting a cell trap to the proximal end of the second lumen, a drain connection at the proximal end of the tubular structure for removing fluids from the proximal end of the second lumen.
Claim 31
Dependent Claim
25 words
The apparatus of claim 26 , wherein the operative opening comprises an opening for drawing abraided material into a distal end of the second lumen.
Claim 32
Dependent Claim
29 words
The apparatus of claim 26 , wherein the cell trap connection further comprises multiple connections for sequentially connecting multiple cell traps to the proximal end of the second lumen.
Claim 33
Dependent Claim
20 words
The apparatus of claim 26 , wherein the operative opening at the distal end of the tube enables arterial thrombectomy.
Claim 34
Dependent Claim
20 words
The apparatus of claim 26 , wherein the operative opening at the distal end of the tube enables internal biopsy.
Claim 35
Dependent Claim
13 words
The apparatus of claim 26 , wherein the tube comprises a flexible catheter.
Claim 36
Dependent Claim
33 words
The apparatus of claim 31 , wherein the flexible catheter is disposed in a flexible endoscope with fiber optics for viewing an environment of the endoscope and the tube at the distal end.
Claim 37
Dependent Claim
28 words
The apparatus of claim 26 , wherein the tube is rigid and wherein the rigid tube is disposed in an operative opening at the end of the tube.
Claim 38
Dependent Claim
29 words
The apparatus of claim 26 , wherein the distal operative opening at the end of the tube is used for external biopsy, wound debriedment, surgical incisions or surgical excisions.
Claim 39
Dependent Claim
18 words
The apparatus of claim 26 , further comprising a cell trap removably connected to the cell trap connector.
Claim 40
Dependent Claim
31 words
The apparatus of claim 26 , further comprising multiple cell traps connected to a cell trap mount for sequentially connecting each cell trap to the proximal end of the second lumen.
Claim 41
Dependent Claim
28 words
The apparatus of claim 35 , wherein the operative opening comprise an opening for exposing tissue to a fluid jet from a distal end of the first lumen.
Claim 42
Dependent Claim
23 words
The apparatus of claim 26 , further comprising a pump connected to the pressure source connection and a controller connected to the pump.
Claim 43
Dependent Claim
22 words
The apparatus of claim 26 , wherein the tubular structure comprises first and second tubes respectively having the first and second lumens.
Claim 44
Dependent Claim
20 words
The apparatus of claim 26 , wherein the tubular structure comprises a single tube having first and second lumens therein.
Claim 45
Dependent Claim
42 words
A diagnostic or therapeutic method comprising directing fluid jets to a tissue, abraiding the tissue, entraining cell clusters from the abraided tissue in a fluid and conveying cell clusters in the fluid, trapping cell clusters from the fluid and discharging the fluid.
Claim 46
Dependent Claim
42 words
A diagnostic or therapeutic method comprising directing fluid jets to a tissue, abraiding the tissue, entraining cell clusters from the abraided tissue in a fluid and conveying cell clusters in the fluid, trapping cell clusters from the fluid and discharging the fluid.
Claim 47
Dependent Claim
37 words
The method of claim 41 wherein the directing further comprises pumping fluid through a first tube and jetting fluid from the first tube toward an opening in a second tube and drawing tissue toward the jetting fluid.
Claim 48
Dependent Claim
20 words
The method of claim 42 wherein the entraining comprises entraining the cell clusters into the opening in the second tube.
Claim 49
Dependent Claim
26 words
The method of claim 43 wherein the trapping comprises receiving cell clusters in a trap and further comprising removing and replacing the trap with another trap.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-06-02 | 2006-12-02 | 2007-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-06-02 | 2010-12-02 | 2011-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-06-02 | 2014-12-02 | 2015-06-03 | $7700.00 | Window Closed / Lapsed |