US6569147B1
Expired / Lapsed
US
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Systems and methods of use for delivering beneficial agents for revascularizing stenotic bypass grafts and other occluded blood vessels and for other purposes
Assignee: DSM Biomedical Inc
•
Filing: 2000-09-22
•
Granted: 2003-05-27
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Expires: 2020-09-22
Abstract
Abstract A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid.
Inventors
- 👤 Douglas G. Evans
- 👤 John E. Nash
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:08
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/32; A61B17/3205; A61B17/3207; A61B17/320758; A61B17/22; A61L; A61L27/00; A61L27/50; A61L27/54; A61L29/00; A61L29/14; A61L29/16; A61L31/00; A61L31/14; A61L31/16; A61B2017/22082; A61B2017/22084; A61L2300/00; A61L2300/20; A61L2300/22; A61L2300/40; A61L2300/416; A61L2300/60; A61L2300/62; A61L2300/622; A61L2300/624; A61L2300/626
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
117 words
An intra-luminal system for locally delivering an infusate liquid comprising at least one beneficial agent to the wall of a lumen in the body of a living being, said system comprising: an infusation means for delivering said infusate liquid, said delivery done at an infusate liquid flow rate, said infusate liquid comprising a beneficial agent; an extraction means for removing an extraction liquid, said removing done at an extraction liquid flow rate, said extraction liquid comprising the beneficial agent, the concentration of the beneficial agent in the extraction liquid either the same or different from the concentration of the beneficial agent in the infusate liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 2
Dependent Claim
117 words
An intra-luminal system for locally delivering an infusate liquid comprising at least one beneficial agent to the wall of a lumen in the body of a living being, said system comprising: an infusation means for delivering said infusate liquid, said delivery done at an infusate liquid flow rate, said infusate liquid comprising a beneficial agent; an extraction means for removing an extraction liquid, said removing done at an extraction liquid flow rate, said extraction liquid comprising the beneficial agent, the concentration of the beneficial agent in the extraction liquid either the same or different from the concentration of the beneficial agent in the infusate liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 3
Dependent Claim
18 words
The intra-luminal system of claim 1 wherein said at least one beneficial agent comprises at least one lipid.
Claim 4
Dependent Claim
14 words
The intra-luminal system of claim 2 wherein said at least one lipid is ceramide.
Claim 5
Dependent Claim
17 words
The intra-luminal system of claim 2 wherein said at least one lipid is sphingolipid or derivitized sphingolipid.
Claim 6
Dependent Claim
15 words
The intra-luminal system of claim 2 wherein said at least one lipid is cell-permeable (C6-ceramide).
Claim 7
Dependent Claim
14 words
The intraluminal system of claim 1 wherein said beneficial agent is an antineoplastic agent.
Claim 8
Dependent Claim
36 words
The intra-luminal system of claim 6 wherein said beneficial agent is an antineoplastic agent selected from the group consisting of alkylating agents, antimetabolites, antimitotic agents, antibiotics, hormones, enzymes, cytoprotective agents, biological response modifiers and monoclonal antibodies.
Claim 9
Dependent Claim
33 words
The intra-luminal system of claim 1 , wherein the infusation means comprises an outlet port and additionally a blocking member arranged to be located distally of said outlet port to block the lumen.
Claim 10
Dependent Claim
13 words
The intra-luminal system of claim 8 wherein said blocking member comprises a balloon.
Claim 11
Independent Claim
162 words
A method for locally delivering at least one beneficial agent to the wall of a lumen in the body of a living being comprising the steps of: A. providing an intra-luminal system comprising an infusate liquid, an infusation means for delivering said at least one beneficial agent, an extraction means for removing an extraction liquid, said infusation means comprising an outlet port, said infusation liquid comprising at least one beneficial agent, B. positioning said intra-luminal system within the body of the being so that said outlet port is within the lumen adjacent a portion of the wall thereof, and C. delivering, at an infusate liquid flow rate, said infusation liquid through said infusation means and out of said outlet port for localized delivery into the adjacent lumen wall portion; and D. removing via the extraction means, at an extraction liquid flow rate, at least a portion of said infusation liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 12
Independent Claim
162 words
A method for locally delivering at least one beneficial agent to the wall of a lumen in the body of a living being comprising the steps of: A. providing an intra-luminal system comprising an infusate liquid, an infusation means for delivering said at least one beneficial agent, an extraction means for removing an extraction liquid, said infusation means comprising an outlet port, said infusation liquid comprising at least one beneficial agent, B. positioning said intra-luminal system within the body of the being so that said outlet port is within the lumen adjacent a portion of the wall thereof, and C. delivering, at an infusate liquid flow rate, said infusation liquid through said infusation means and out of said outlet port for localized delivery into the adjacent lumen wall portion; and D. removing via the extraction means, at an extraction liquid flow rate, at least a portion of said infusation liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 13
Dependent Claim
17 words
The method of claim 10 wherein said at least one beneficial agent comprises at least one lipid.
Claim 14
Dependent Claim
13 words
The method of claim 11 wherein said at least one lipid is ceramide.
Claim 15
Dependent Claim
16 words
The method of claim 11 wherein said at least one lipid is sphingolipid or derivitized sphingolipid.
Claim 16
Dependent Claim
14 words
The method of claim 11 wherein said at least one lipid is cell-permeable (C6-ceramide).
Claim 17
Dependent Claim
13 words
The method of claim 10 wherein said beneficial agent is an antineoplastic agent.
Claim 18
Dependent Claim
35 words
The method of claim 15 wherein said beneficial agent is an antineoplastic agent selected from the group consisting of alkylating agents, antimetabolites, antimitotic agents, antibiotics, hormones, enzymes, cytoprotective agents, biological response modifiers and monoclonal antibodies.
Claim 19
Dependent Claim
31 words
The method of claim 10 wherein the infusation means comprises an outlet port and additionally a blocking member arranged to be located distally of said outlet port to block the lumen.
Claim 20
Dependent Claim
12 words
The method of claim 17 wherein said blocking member comprises a balloon.
Claim 21
Dependent Claim
124 words
An intra-luminal system for locally delivering an infusate liquid comprising at least one beneficial agent to the wall of a lumen in the body of a living being, said system comprising: a working head to open the lumen; an infusation means for delivering said infusate liquid, said delivering done at an infusate liquid flow rate, said infusate liquid comprising a beneficial agent; an extraction means for removing an extraction liquid, said removing done at an extraction liquid flow rate, said extraction liquid comprising the beneficial agent, the concentration of the beneficial agent in the extraction liquid either the same or different from the concentration of the beneficial agent in the infusate liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 22
Dependent Claim
124 words
An intra-luminal system for locally delivering an infusate liquid comprising at least one beneficial agent to the wall of a lumen in the body of a living being, said system comprising: a working head to open the lumen; an infusation means for delivering said infusate liquid, said delivering done at an infusate liquid flow rate, said infusate liquid comprising a beneficial agent; an extraction means for removing an extraction liquid, said removing done at an extraction liquid flow rate, said extraction liquid comprising the beneficial agent, the concentration of the beneficial agent in the extraction liquid either the same or different from the concentration of the beneficial agent in the infusate liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 23
Dependent Claim
18 words
The intra-luminal system of claim 19 wherein said at least one beneficial agent comprises at least one lipid.
Claim 24
Dependent Claim
14 words
The intra-luminal system of claim 20 wherein said at least one lipid is ceramide.
Claim 25
Dependent Claim
17 words
The intra-luminal system of claim 20 wherein said at least one lipid is sphingolipid or derivitized sphingolipid.
Claim 26
Dependent Claim
15 words
The intra-luminal system of claim 20 wherein said at least one lipid is cell-permeable (C6-ceramide).
Claim 27
Dependent Claim
14 words
The intraluminal system of claim 19 wherein said beneficial agent is an antineoplastic agent.
Claim 28
Dependent Claim
35 words
The intra-luminal system of claim wherein said beneficial agent is an antineoplastic agent selected from the group consisting of alkylating agents, antimetabolites, antimitotic agents, antibiotics, hormones, enzymes, cytoprotective agents, biological response modifiers and monoclonal antibodies.
Claim 29
Dependent Claim
32 words
The intra-luminal system of claim 19 wherein the infusation means comprises an outlet port and additionally a blocking member arranged to be located distally of said outlet port to block the lumen.
Claim 30
Dependent Claim
13 words
The intra-luminal system of claim 26 wherein said blocking member comprises a balloon.
Claim 31
Dependent Claim
23 words
A system of claim 19 wherein the working head creates debris and the extraction liquid comprises at least a portion of said debris.
Claim 32
Independent Claim
165 words
A method for locally delivering at least one beneficial agent to the wall of a lumen in the body of a living being comprising the steps of: A. providing an intra-luminal system comprising a working head, infusate liquid, an infusation means for delivering said drug, an extraction means for removing an extraction liquid, said infusation means comprising an outlet port, said infusation liquid comprising at least one beneficial agent, B. positioning said intra-luminal system within the body of the being so that that the working head and said outlet port is within the lumen adjacent a portion of the wall thereof, and C. delivering, at an infusate liquid flow rate, said infusation liquid through said infusation means and out of said outlet port for localized delivery into the adjacent lumen wall portion; and D. removing via the extraction means, at an extraction liquid flow rate, at least a portion of said infusation liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 33
Independent Claim
165 words
A method for locally delivering at least one beneficial agent to the wall of a lumen in the body of a living being comprising the steps of: A. providing an intra-luminal system comprising a working head, infusate liquid, an infusation means for delivering said drug, an extraction means for removing an extraction liquid, said infusation means comprising an outlet port, said infusation liquid comprising at least one beneficial agent, B. positioning said intra-luminal system within the body of the being so that that the working head and said outlet port is within the lumen adjacent a portion of the wall thereof, and C. delivering, at an infusate liquid flow rate, said infusation liquid through said infusation means and out of said outlet port for localized delivery into the adjacent lumen wall portion; and D. removing via the extraction means, at an extraction liquid flow rate, at least a portion of said infusation liquid; wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
Claim 34
Dependent Claim
17 words
The method of claim 29 wherein said at least one beneficial agent comprises at least one lipid.
Claim 35
Dependent Claim
13 words
The method of claim 30 wherein said at least one lipid is ceramide.
Claim 36
Dependent Claim
16 words
The method of claim 30 wherein said at least one lipid is sphingolipid or derivitized sphingolipid.
Claim 37
Dependent Claim
14 words
The method of claim 30 wherein said at least one lipid is cell-permeable (C6-ceramide).
Claim 38
Dependent Claim
14 words
The method of claim 29 , wherein said beneficial agent is an antineoplastic agent.
Claim 39
Dependent Claim
35 words
The method of claim 34 wherein said beneficial agent is an antineoplastic agent selected from the group consisting of alkylating agents, antimetabolites, antimitotic agents, antibiotics, hormones, enzymes, cytoprotective agents, biological response modifiers and monoclonal antibodies.
Claim 40
Dependent Claim
31 words
The method of claim 29 wherein the infusation means comprises an outlet port and additionally a blocking member arranged to be located distally of said outlet port to block the lumen.
Claim 41
Dependent Claim
12 words
The method of claim 36 wherein said blocking member comprises a balloon.
Claim 42
Dependent Claim
23 words
A system of claim 29 wherein the working head creates debris and the extraction liquid comprises at least a portion of said debris.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2006-05-26 | 2006-11-25 | 2007-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-05-26 | 2010-11-25 | 2011-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-05-26 | 2014-11-25 | 2015-05-27 | $7700.00 | Window Closed / Lapsed |