EP0806212A1
Expired / Lapsed
EP
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Device for incorporation and release of biologically active agents
Assignee: Chienna BV
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Filing: 1997-05-12
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Granted: —
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Expires: 2017-05-12
Abstract
Abstract The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.
Inventors
- 👤 Eugenia Ribeiro De Sousa Fidalgo Leitao
- 👤 Joost Dick De Bruijn
- 👤 Hai-Bo Wen
- 👤 Klaas De Groot
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:58
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61L27/28; A61L27/30; A61L27/32; A61F2002/30001; A61F2002/30667; A61F2002/30677; A61F2002/30906; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00023; A61F2310/00179; A61F2310/00389; A61F2310/00592; A61F2310/00796; A61F2310/0097; A61F2310/00976; A61L2300/00; A61L2300/20; A61L2300/22; A61L2300/23; A61L2300/232; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/416; A61L2300/43; A61L2300/60; A61L2300/606
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
35 words
An implantable device of a material having a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm, said surface being coated with a layer comprising calcium ions and phosphate ions.
Claim 2
Dependent Claim
33 words
An implantable device according to claim 1, wherein said layer further comprises a growth factor, a lipid, a (lipo)polysaccharide, a cytostatic agent, a hormone, an antibiotic, a protein and/or another biologically active agent.
Claim 3
Dependent Claim
22 words
An implantable device according to claim 1 or 2, having a surface roughness with an average depth between 20 and 1,000 nm.
Claim 4
Dependent Claim
34 words
An implantable device according to any one of claims 1-3, wherein said layer of calcium phosphate has a thickness of 50 nm - 200 µm, in particular of between 1000 nm and 50 µm.
Claim 5
Dependent Claim
35 words
An implantable device according to any one of claims 1-4, wherein said material is a metal, a metal alloy, a ceramic material, a natural or synthetic polymer or a composite of any of these materials.
Claim 6
Dependent Claim
54 words
A process for producing an implantable device, comprising subjecting a porous or non-porous material to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm is obtained, and subsequently subjecting the surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions.
Claim 7
Dependent Claim
16 words
A process according to claim 6, wherein said solution has a pH of 4-10, preferably 6-8.
Claim 8
Dependent Claim
34 words
A process according to claim 6 or 7, wherein said solution further contains a growth factor, a lipid, a (lipo)polysaccharide, a hormone, a cytostatic agent, an antibiotic, a protein and/or another biologically active agent.
Claim 9
Dependent Claim
23 words
A process according to any one of claims 6-8, wherein said subjecting to precipitation of calcium phosphate is carried out in two stages.
Claim 10
Dependent Claim
45 words
Use of a device according to any one of claims 1-5, or produced according to any one of claims 6-9, as a bone substitute, a joint prosthesis, a dental implant, a maxillofacial implant, a vertebral surgery aid, a transcutaneous device or any other hard-tissue-related device.
References Cited (Backward Citations)
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US5344457A
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US5456723A
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EP0450939A2
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WO1995013101A1
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WO1995013102A1
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