US6543455B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cell harvesting method
Assignee: Bonutti Skeletal Innovations LLC
•
Filing: 2002-01-11
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Granted: 2003-04-08
•
Expires: 2022-01-11
Abstract
Abstract A percutaneous tissue removal apparatus having a flexible drill shaft, a cutting tip mounted on the shaft a power source for transmitting motion to the shaft to move the cutting tip against tissue and a suction source for removing tissue fragments along the shaft to a location outside the tissue mass while cutting. The apparatus may include a container for collecting one or more selected components of the harvested tissue fragments for implantation of the fragments preferably into the body of the patient from whom they were removed. Where the tissue to be cut is bone, a cutting tip is preferably made of a polymeric material which is softer than the cortical portion of the bone, although the cutting tip may be made of a ceramic or a composite material. A second flexible shaft may be provided either within or about the flexible drill shaft.
Inventors
- 👤 Peter M. Bonutti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 21:57
CPC Classifications
A; A61; A61B; A61B10/00; A61B10/02; A61B10/0233; A61B10/025; A61B17/00; A61B17/16; A61B17/1635; A61B17/32; A61B17/320016; A61B17/32002; A61B17/1613; A61B17/1615; A61B17/1631; A61B2017/00831; A61B2017/00969; A61B2217/00; A61B2217/002; A61B2217/005; A61B2217/007; A61M; A61M1/00; A61M1/71; A61M1/79
Claims Analysis
Total Claims: 55
Claim 1
Independent Claim
53 words
A method for harvesting cells for therapeutic use comprising the steps of: cutting tissue fragments from a tissue of a donor; suctioning the tissue fragments through a shaft to a location outside of the donor; separating cells from the tissue fragments; and implanting the cells into a recipient, wherein the cells are viable.
Claim 2
Independent Claim
53 words
A method for harvesting cells for therapeutic use comprising the steps of: cutting tissue fragments from a tissue of a donor; suctioning the tissue fragments through a shaft to a location outside of the donor; separating cells from the tissue fragments; and implanting the cells into a recipient, wherein the cells are viable.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein rotating motion is used to cut the tissue fragments.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein reciprocating motion is used to cut the tissue fragments.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein the shaft is flexible.
Claim 6
Dependent Claim
13 words
The method of claim 1 further comprising the step of irrigating the tissue.
Claim 7
Dependent Claim
11 words
The method of claim 5 wherein the irrigation and suction alternate.
Claim 8
Dependent Claim
13 words
The method of claim 5 wherein the irrigation and suction occur substantially simultaneously.
Claim 9
Dependent Claim
16 words
The method of claim 1 wherein the shaft is inserted percutaneously through skin of the donor.
Claim 10
Dependent Claim
14 words
The method of claim 1 wherein the donor and recipient are the same individual.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein the donor and recipient are different individuals.
Claim 12
Dependent Claim
16 words
The method of claim 1 wherein the cells are at least partially separated using a filter.
Claim 13
Dependent Claim
15 words
The method of claim 1 wherein the cells are at least partially separated using centrifugation.
Claim 14
Dependent Claim
16 words
The method of claim 1 wherein the cells are at least partially separated using a press.
Claim 15
Dependent Claim
21 words
The method of claim 1 wherein the tissue is selected from the group consisting of bone, cartilage, muscle, and fetal tissue.
Claim 16
Dependent Claim
31 words
The method of claim 1 wherein prior to implantation the cells are combined with a material selected from the group consisting of tissue grafts, collagen, antibiotics, and bone growth promoting substances.
Claim 17
Dependent Claim
16 words
The method of claim 15 wherein the bone growth promoting substances are hydroxyapatite or tricalcium phosphate.
Claim 18
Dependent Claim
14 words
The method of claim 1 wherein an adhesive element is added to the cells.
Claim 19
Dependent Claim
13 words
The method of claim 17 wherein the adhesive element is blood or fibrin.
Claim 20
Dependent Claim
17 words
The method of claim 1 further comprising the step of adding the cells to a biodegradable material.
Claim 21
Dependent Claim
16 words
The method of claim 1 further comprising the step of adding the cells to a polymer.
Claim 22
Dependent Claim
16 words
The method of claim 1 further comprising the step of sealing the cells in the recipient.
Claim 23
Dependent Claim
22 words
The method of claim 1 wherein at least one of the steps of cutting, suctioning, and implanting is performed under x-ray guidance.
Claim 24
Dependent Claim
22 words
The method of claim 1 wherein at least one of the steps of cutting, suctioning, and implanting is performed through a cannula.
Claim 25
Dependent Claim
26 words
The method of claim 1 wherein at least one of the steps of cutting, suctioning, and implanting is performed under endoscopic, arthroscopic, or fiber optic guidance.
Claim 26
Dependent Claim
14 words
The method of claim 1 wherein the cells include at least two cell types.
Claim 27
Dependent Claim
19 words
The method of claim 1 wherein the cells are formed into an implant prior to implantation into the recipient.
Claim 28
Independent Claim
71 words
A method for harvesting cells for therapeutic use comprising the steps of: cutting tissue fragments from a tissue of a donor; collecting the tissue fragments at a location outside of the donor; separating cells from the tissue fragments; combining the cells with a material selected from the group consisting of tissue grafts, collagen, antibiotics, and bone growth promoting substances; and implanting the cells into a recipient, wherein the cells are viable.
Claim 29
Independent Claim
71 words
A method for harvesting cells for therapeutic use comprising the steps of: cutting tissue fragments from a tissue of a donor; collecting the tissue fragments at a location outside of the donor; separating cells from the tissue fragments; combining the cells with a material selected from the group consisting of tissue grafts, collagen, antibiotics, and bone growth promoting substances; and implanting the cells into a recipient, wherein the cells are viable.
Claim 30
Dependent Claim
15 words
The method of claim 27 wherein rotating motion is used to cut the tissue fragments.
Claim 31
Dependent Claim
15 words
The method of claim 27 wherein reciprocating motion is used to cut the tissue fragments.
Claim 32
Dependent Claim
17 words
The method of claim 27 wherein the tissue fragments are collected using suction through a flexible shaft.
Claim 33
Dependent Claim
13 words
The method of claim 30 further comprising the step of irrigating the tissue.
Claim 34
Dependent Claim
11 words
The method of claim 31 wherein the irrigation and suction alternate.
Claim 35
Dependent Claim
13 words
The method of claim 31 wherein the irrigation and suction occur substantially simultaneously.
Claim 36
Dependent Claim
16 words
The method of claim 30 wherein the shaft is inserted percutaneously through skin of the donor.
Claim 37
Dependent Claim
14 words
The method of claim 27 wherein the donor and recipient are the same individual.
Claim 38
Dependent Claim
13 words
The method of claim 27 wherein the donor and recipient are different individuals.
Claim 39
Dependent Claim
16 words
The method of claim 27 wherein the cells are at least partially separated using a filter.
Claim 40
Dependent Claim
15 words
The method of claim 27 wherein the cells are at least partially separated using centrifugation.
Claim 41
Dependent Claim
16 words
The method of claim 27 wherein the cells are at least partially separated using a press.
Claim 42
Dependent Claim
21 words
The method of claim 27 wherein the tissue is selected from the group consisting of bone, cartilage, muscle, and fetal tissue.
Claim 43
Dependent Claim
16 words
The method of claim 27 wherein the bone growth promoting substances are hydroxyapatite or tricalcium phosphate.
Claim 44
Dependent Claim
14 words
The method of claim 27 wherein an adhesive element is added to the cells.
Claim 45
Dependent Claim
13 words
The method of claim 42 wherein the adhesive element is blood or fibrin.
Claim 46
Dependent Claim
17 words
The method of claim 27 further comprising the step of adding the cells to a biodegradable material.
Claim 47
Dependent Claim
16 words
The method of claim 27 further comprising the step of adding the cells to a polymer.
Claim 48
Dependent Claim
16 words
The method of claim 27 further comprising the step of sealing the cells in the recipient.
Claim 49
Dependent Claim
22 words
The method of claim 27 wherein at least one of the steps of cutting, suctioning, and implanting is performed under x-ray guidance.
Claim 50
Dependent Claim
22 words
The method of claim 27 wherein at least one of the steps of cutting, suctioning, and implanting is performed through a cannula.
Claim 51
Dependent Claim
26 words
The method of claim 27 wherein at least one of the steps of cutting, suctioning, and implanting is performed under endoscopic, arthroscopic, or fiber optic guidance.
Claim 52
Dependent Claim
14 words
The method of claim 27 wherein the cells include at least two cell types.
Claim 53
Dependent Claim
19 words
The method of claim 27 wherein the cells are formed into an implant prior to implantation into the recipient.
Claim 54
Independent Claim
75 words
A method for harvesting cells for therapeutic use comprising the steps of: cutting tissue fragments from a tissue of a donor; removing the tissue fragments from the donor to a location outside of the donor; separating cells from the tissue fragments; and implanting the cells into a recipient, wherein the cells are viable and at least one of the steps of cutting, removing, separating, and implanting is performed under endoscopic, arthroscopic, or fiber optic guidance.
Claim 55
Independent Claim
75 words
A method for harvesting cells for therapeutic use comprising the steps of: cutting tissue fragments from a tissue of a donor; removing the tissue fragments from the donor to a location outside of the donor; separating cells from the tissue fragments; and implanting the cells into a recipient, wherein the cells are viable and at least one of the steps of cutting, removing, separating, and implanting is performed under endoscopic, arthroscopic, or fiber optic guidance.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-04-07 | 2006-10-07 | 2007-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-04-07 | 2010-10-07 | 2011-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-04-07 | 2014-10-07 | 2015-04-08 | $7700.00 | Window Closed / Lapsed |