US6454741B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aspiration method
Assignee: Kardiametrix LLC
•
Filing: 2000-03-24
•
Granted: 2002-09-24
•
Expires: 2020-03-24
Abstract
Abstract A method for the treatment of a stenosis or an occlusion in a blood vessel in which an occlusive device is first delivered and activated at a site distal to the occlusion to at least partially occlude the vessel. A therapy catheter is then introduced to treat the occlusion and a debris removal device is delivered to aspirate debris from the vessel. The present invention eliminates the need for a separate irrigation catheter and irrigation fluid which allows the procedure to be performed quickly and efficiently, and is especially useful in the removal of occlusion from saphenous vein graft, the coronary and carotid arteries, arteries above the aortic arch and vessels of similar size and pressure.
Inventors
- 👤 Ketan P. Muni
- 👤 Gholam Reza Zadno-Azizi
- 👤 Celso Bagaoisan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:27
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/104; A61B; A61B17/00; A61B17/22; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61B18/245; A61B2017/22051; A61B2017/22065; A61B2017/22067; A61B2017/22082; A61B2017/22084; A61B17/32; A61B17/3205; A61B17/3207; A61B2017/320716; A61M25/01; A61M25/09; A61M2025/09175; A61M2025/09183; A61M25/1011; A61M2025/1015; A61M2025/1043; A61M2025/1052; A61M2025/109; A61M2025/1093
Claims Analysis
Total Claims: 74
Claim 1
Independent Claim
232 words
A method of treatment of a blood vessel in which blood fluid flows proximally to distally, said method comprising: delivering a guidewire having a proximal end and a distal end and an expandable device thereon into the blood vessel, said expandable device being actuatable between a nonexpanded state and an expanded state, said expandable device when in said expanded state forming a barrier sufficient to inhibit emboli suspended in said fluid from migrating past the barrier in a proximal to distal direction; preventing emboli from moving in a distal to proximal direction by exposing said expandable device to blood fluid pressure within said vessel; advancing a catheter having a lumen in fluid communication with a distal opening in the catheter, said advancing comprising moving said distal opening relative to said expandable device within the blood vessel such that said opening is distal to at least a portion of an occlusive substance within said blood vessel, said occlusive substance comprising said emboli suspended in said fluid; and drawing fluid from the vessel into the distal opening such that (a) a fluid flow is created in the lumen in a distal to proximal direction, and (b) said fluid flow is simultaneously created in said vessel in a proximal to distal direction, whereby said emboli are carried by said fluid flow from said vessel into said distal opening and through said lumen of said catheter.
Claim 2
Independent Claim
232 words
A method of treatment of a blood vessel in which blood fluid flows proximally to distally, said method comprising: delivering a guidewire having a proximal end and a distal end and an expandable device thereon into the blood vessel, said expandable device being actuatable between a nonexpanded state and an expanded state, said expandable device when in said expanded state forming a barrier sufficient to inhibit emboli suspended in said fluid from migrating past the barrier in a proximal to distal direction; preventing emboli from moving in a distal to proximal direction by exposing said expandable device to blood fluid pressure within said vessel; advancing a catheter having a lumen in fluid communication with a distal opening in the catheter, said advancing comprising moving said distal opening relative to said expandable device within the blood vessel such that said opening is distal to at least a portion of an occlusive substance within said blood vessel, said occlusive substance comprising said emboli suspended in said fluid; and drawing fluid from the vessel into the distal opening such that (a) a fluid flow is created in the lumen in a distal to proximal direction, and (b) said fluid flow is simultaneously created in said vessel in a proximal to distal direction, whereby said emboli are carried by said fluid flow from said vessel into said distal opening and through said lumen of said catheter.
Claim 3
Dependent Claim
18 words
The method of claim 1 , wherein the occlusive substance includes material on a wall of the vessel.
Claim 4
Dependent Claim
34 words
The method of claim 2 , wherein said advancing comprises moving said distal opening such that said distal opening is distal to at least some of the material on the wall of the vessel.
Claim 5
Dependent Claim
25 words
The method of claim 1 , further comprising moving the distal opening in the catheter relative to the expandable device during said drawing of fluid.
Claim 6
Dependent Claim
14 words
The method of claim 1 , wherein said expandable device is an inflatable balloon.
Claim 7
Dependent Claim
13 words
The method of claim 1 , wherein said expandable device is a filter.
Claim 8
Dependent Claim
36 words
The method of claim 1 , further comprising advancing a guide catheter until a distal end of the guide catheter is positioned proximal to the emboli, and wherein said catheter is advanced through said guide catheter.
Claim 9
Dependent Claim
15 words
The method of claim 1 , wherein said blood vessel comprises a saphenous vein graft.
Claim 10
Dependent Claim
17 words
The method of claim 8 , wherein said fluid pressure is provided by blood from the aorta.
Claim 11
Dependent Claim
14 words
The method of claim 1 , wherein said blood vessel comprises a carotid artery.
Claim 12
Dependent Claim
23 words
The method of claim 1 , wherein the emboli are located in a segment of the blood vessel having substantially no side branches.
Claim 13
Dependent Claim
14 words
The method of claim 1 , wherein the catheter is advanced over the guidewire.
Claim 14
Independent Claim
117 words
A method for the evacuation of emboli from a blood vessel comprising: positioning an expandable device distal to a location in the vessel having an occlusion on the walls of said vessel; positioning a catheter having a lumen in fluid communication with a distal opening in the catheter such that said opening is distal to said location; drawing fluid from the vessel into the distal opening such that emboli broken off from said occlusion are carried by said fluid from said vessel into said distal opening and through said lumen of said catheter; and moving the distal opening in the catheter until it is proximal to said location during the drawing of fluid into the distal opening.
Claim 15
Independent Claim
117 words
A method for the evacuation of emboli from a blood vessel comprising: positioning an expandable device distal to a location in the vessel having an occlusion on the walls of said vessel; positioning a catheter having a lumen in fluid communication with a distal opening in the catheter such that said opening is distal to said location; drawing fluid from the vessel into the distal opening such that emboli broken off from said occlusion are carried by said fluid from said vessel into said distal opening and through said lumen of said catheter; and moving the distal opening in the catheter until it is proximal to said location during the drawing of fluid into the distal opening.
Claim 16
Dependent Claim
25 words
The method of claim 13 , wherein positioning said expandable device further comprises delivering a guidewire into said vessel, said guidewire carrying said expandable device.
Claim 17
Dependent Claim
18 words
The method of claim 14 , wherein said catheter is positioned in the blood vessel over said guidewire.
Claim 18
Dependent Claim
23 words
The method of claim 13 , further comprising actuating said expandable device into an expanded position prior to drawing fluid from the vessel.
Claim 19
Dependent Claim
39 words
The method of claim 13 , wherein said drawing fluid further comprises creating a fluid flow in the lumen in a distal to proximal direction, and simultaneously creating fluid flow in the vessel in a proximal to distal direction.
Claim 20
Dependent Claim
26 words
The method of claim 13 , wherein the distal opening in the catheter is positioned distal said location more than once during the drawing of fluid.
Claim 21
Dependent Claim
14 words
The method of claim 13 , wherein said expandable device is an inflatable balloon.
Claim 22
Dependent Claim
13 words
The method of claim 13 , wherein said expandable device is a filter.
Claim 23
Dependent Claim
36 words
The method of claim 13 , further comprising, prior to drawing fluid into the distal opening of the catheter, performing therapy on the occlusion, the performing of therapy causing emboli to break off from the occlusion.
Claim 24
Independent Claim
214 words
A method for the treatment of an occlusion in a blood vessel having a fluid pressure of at least 0.2 psi, comprising: inserting a guidewire having an occlusive device at its distal end into said blood vessel, until said occlusive device is distal to said occlusion; activating said occlusive device to at least partially occlude said vessel distal to said occlusion and create a working area around said occlusion; advancing a therapy catheter into said blood vessel until it reaches said occlusion; performing therapy on said occlusion; utilizing fluid pressure within said vessel to inhibit particles produced during therapy from substantial migration in a direction proximal to said occlusion; removing said therapy catheter; delivering an aspiration catheter having a proximal end and a distal end over said guidewire until the distal end of said aspiration catheter is at a location proximal to the occlusive device and distal to the occlusion; creating a flow of fluid within said vessel in a proximal to distal direction by aspirating fluid from said working area inside the vessel through said distal end of said aspiration catheter, whereby said particles are removed from the working area and said fluid pressure provides fluid to replace fluid aspirated from the working area; and deactivating said occlusive device and removing said catheter.
Claim 25
Independent Claim
214 words
A method for the treatment of an occlusion in a blood vessel having a fluid pressure of at least 0.2 psi, comprising: inserting a guidewire having an occlusive device at its distal end into said blood vessel, until said occlusive device is distal to said occlusion; activating said occlusive device to at least partially occlude said vessel distal to said occlusion and create a working area around said occlusion; advancing a therapy catheter into said blood vessel until it reaches said occlusion; performing therapy on said occlusion; utilizing fluid pressure within said vessel to inhibit particles produced during therapy from substantial migration in a direction proximal to said occlusion; removing said therapy catheter; delivering an aspiration catheter having a proximal end and a distal end over said guidewire until the distal end of said aspiration catheter is at a location proximal to the occlusive device and distal to the occlusion; creating a flow of fluid within said vessel in a proximal to distal direction by aspirating fluid from said working area inside the vessel through said distal end of said aspiration catheter, whereby said particles are removed from the working area and said fluid pressure provides fluid to replace fluid aspirated from the working area; and deactivating said occlusive device and removing said catheter.
Claim 26
Dependent Claim
55 words
The method of claim 22 , wherein said aspiration catheter comprises a hollow lumen and a separate second lumen for receiving said guidewire, and wherein said aspiration catheter is delivered by inserting a proximal end of said guidewire into said second lumen, and slidably advancing said second lumen of said aspiration catheter over said guidewire.
Claim 27
Dependent Claim
42 words
The method of claim 22 , wherein said distal end of said aspiration catheter is inserted at least one time to a position no more than about 5 cm proximal to said occlusive device and thereafter slidably withdrawn in a proximal direction.
Claim 28
Dependent Claim
31 words
The method of claim 22 , wherein said blood vessel is selected from the group consisting of a saphenous vein graft, a coronary artery, and a vessel above the aortic arch.
Claim 29
Dependent Claim
23 words
The method of claim 22 , wherein said blood vessel has a fluid flow rate of at least about 10 cc per minute.
Claim 30
Dependent Claim
25 words
The method of claim 22 , wherein said blood vessel has a fluid flow rate of from about 60 to about 80 cc per minute.
Claim 31
Dependent Claim
24 words
The method of claim 22 , further comprising inserting a guide catheter to aid in the insertion of said occlusive device and said guidewire.
Claim 32
Dependent Claim
18 words
The method of claim 22 , wherein activating said occlusive device results in the vessel being substantially occluded.
Claim 33
Dependent Claim
21 words
The method of claim 22 , wherein said occlusive device is a balloon and said activating step comprises inflating said balloon.
Claim 34
Dependent Claim
27 words
The method of claim 22 , wherein said occlusive device is a filter and said activating step comprises deploying said filter to prevent migration of particles downstream.
Claim 35
Dependent Claim
21 words
The method of claim 22 , wherein performing said therapy comprises delivering a drug directly to the site of said occlusion.
Claim 36
Dependent Claim
29 words
The method of claim 22 , wherein performing said therapy comprises creating a venturi effect within said vessel to aspirate said occlusion, and wherein the fluid aspiration occurs simultaneously.
Claim 37
Dependent Claim
28 words
The method of claim 22 , wherein performing said therapy comprises creating fluid turbulence within said vessel to aspirate said occlusion, and wherein the fluid aspiration occurs simultaneously.
Claim 38
Dependent Claim
45 words
The method of claim 22 , wherein said therapy catheter is selected from the group consisting of a thrombectomy catheter, a rheolitic device, and a device which creates a venturi effect within the vessel, and wherein the therapy and the fluid aspiration are performed simultaneously.
Claim 39
Dependent Claim
22 words
The method of claim 22 , further comprising moving the distal end of the aspiration catheter within said working area during aspiration.
Claim 40
Dependent Claim
24 words
The method of claim 36 , wherein the distal end of the aspiration catheter is moved in a distal to proximal direction during aspiration.
Claim 41
Dependent Claim
24 words
The method of claim 36 , wherein the distal end of the aspiration catheter is moved in a proximal to distal direction during aspiration.
Claim 42
Dependent Claim
23 words
The method of claim 22 , wherein the emboli are located in a segment of the blood vessel having substantially no side branches.
Claim 43
Independent Claim
232 words
A method of treatment of a blood vessel in which blood flows proximally to distally at a location having an occlusion on the walls of said vessel that constricts said vessel, said method comprising: delivering a guidewire having a proximal end and a distal end and an expandable device thereon into the blood vessel, said expandable device being actuatable between a nonexpanded state and an expanded state, said expandable device when in said expanded state forming a barrier sufficient to inhibit emboli in said blood from migrating past the barrier in a proximal to distal direction; preventing emboli from moving in a distal to proximal direction by exposing said expandable device to blood flowing in a proximal to distal direction; advancing a catheter having a lumen in fluid communication with a distal opening in the catheter, said advancing comprising moving said distal opening relative to said expandable device within the blood vessel such that said opening is distal to said occlusion within said blood vessel; and drawing blood from the vessel into the distal opening such that (a) a blood flow is created in the lumen in a distal to proximal direction, and (b) said blood flow is simultaneously created in said vessel in a proximal to distal direction, whereby said emboli are carried by said blood flow from said vessel into said distal opening and through said lumen of said catheter.
Claim 44
Independent Claim
232 words
A method of treatment of a blood vessel in which blood flows proximally to distally at a location having an occlusion on the walls of said vessel that constricts said vessel, said method comprising: delivering a guidewire having a proximal end and a distal end and an expandable device thereon into the blood vessel, said expandable device being actuatable between a nonexpanded state and an expanded state, said expandable device when in said expanded state forming a barrier sufficient to inhibit emboli in said blood from migrating past the barrier in a proximal to distal direction; preventing emboli from moving in a distal to proximal direction by exposing said expandable device to blood flowing in a proximal to distal direction; advancing a catheter having a lumen in fluid communication with a distal opening in the catheter, said advancing comprising moving said distal opening relative to said expandable device within the blood vessel such that said opening is distal to said occlusion within said blood vessel; and drawing blood from the vessel into the distal opening such that (a) a blood flow is created in the lumen in a distal to proximal direction, and (b) said blood flow is simultaneously created in said vessel in a proximal to distal direction, whereby said emboli are carried by said blood flow from said vessel into said distal opening and through said lumen of said catheter.
Claim 45
Dependent Claim
27 words
The method of claim 40 , wherein said advancing comprises moving said distal opening such that said opening is distal to at least some of the emboli.
Claim 46
Dependent Claim
35 words
The method of claim 40 , further comprising moving the distal opening in the catheter in a distal to proximal direction during said drawing of blood to cross at least a portion of the occlusion.
Claim 47
Dependent Claim
14 words
The method of claim 40 , wherein said expandable device is an inflatable balloon.
Claim 48
Dependent Claim
13 words
The method of claim 40 , wherein said expandable device is a filter.
Claim 49
Dependent Claim
14 words
The method of claim 40 , wherein said catheter is advanced over the guidewire.
Claim 50
Dependent Claim
36 words
The method of claim 40 , further comprising, prior to drawing blood into the distal opening of the catheter, performing therapy on the occlusion, the performing of therapy causing emboli to break off from the occlusion.
Claim 51
Independent Claim
104 words
A method for the evacuation of emboli from a blood vessel in which therapy has been performed on a lesion in the vessel, comprising: positioning a catheter having a lumen in fluid communication with a distal opening in the catheter such that said opening is in the region of said emboli; drawing fluid from the vessel into the distal opening such that emboli are carried by said fluid flow from said vessel into said distal opening and through said lumen of said catheter; and moving the distal opening in the catheter relative to said lesion while continuing to draw fluid into the distal opening.
Claim 52
Independent Claim
104 words
A method for the evacuation of emboli from a blood vessel in which therapy has been performed on a lesion in the vessel, comprising: positioning a catheter having a lumen in fluid communication with a distal opening in the catheter such that said opening is in the region of said emboli; drawing fluid from the vessel into the distal opening such that emboli are carried by said fluid flow from said vessel into said distal opening and through said lumen of said catheter; and moving the distal opening in the catheter relative to said lesion while continuing to draw fluid into the distal opening.
Claim 53
Dependent Claim
32 words
The method of claim 47 , wherein the distal opening in the catheter is positioned at a location distal to at least a portion of an occlusive substance within said blood vessel.
Claim 54
Dependent Claim
12 words
The method of claim 48 , wherein the occlusive substance comprises emboli.
Claim 55
Dependent Claim
22 words
The method of claim 48 , wherein the occlusive substance includes material that is attached to the walls of the blood vessel.
Claim 56
Dependent Claim
35 words
The method of claim 48 , wherein the distal opening in the catheter is moved in a distal to proximal direction until it is proximal to said location while drawing fluid into the distal opening.
Claim 57
Dependent Claim
32 words
The method of claim 51 , further comprising moving the distal opening in the catheter in a proximal to distal direction after moving the distal opening in a distal to proximal direction.
Claim 58
Dependent Claim
18 words
The method of claim 47 , wherein said catheter is delivered into the blood vessel over a guidewire.
Claim 59
Dependent Claim
17 words
The method of claim 53 , wherein the guidewire includes an occlusive device at its distal end.
Claim 60
Dependent Claim
14 words
The method of claim 54 , wherein the occlusive device is an inflatable balloon.
Claim 61
Dependent Claim
13 words
The method of claim 54 , wherein the occlusive device is a filter.
Claim 62
Independent Claim
148 words
A method for the evacuation of emboli from a blood vessel comprising: delivering a guidewire carrying an expandable device near its distal end to a location in the vessel having an occlusion on the walls of the vessel; actuating said expandable device to inhibit emboli in said blood vessel from migrating past said expandable device; positioning a catheter having a lumen in fluid communication with a distal opening in the catheter over said guidewire such that said opening is proximal to said expandable device; drawing fluid from the vessel into the distal opening such that emboli are carried by said fluid from said vessel into said distal opening and through said lumen of said catheter, and moving the distal opening of the catheter during the drawing of fluid into the distal opening in a direction such that the distal opening crosses at least a portion of the occlusion.
Claim 63
Independent Claim
148 words
A method for the evacuation of emboli from a blood vessel comprising: delivering a guidewire carrying an expandable device near its distal end to a location in the vessel having an occlusion on the walls of the vessel; actuating said expandable device to inhibit emboli in said blood vessel from migrating past said expandable device; positioning a catheter having a lumen in fluid communication with a distal opening in the catheter over said guidewire such that said opening is proximal to said expandable device; drawing fluid from the vessel into the distal opening such that emboli are carried by said fluid from said vessel into said distal opening and through said lumen of said catheter, and moving the distal opening of the catheter during the drawing of fluid into the distal opening in a direction such that the distal opening crosses at least a portion of the occlusion.
Claim 64
Dependent Claim
19 words
The method of claim 57 , wherein the expandable device is actuated at a location distal to the occlusion.
Claim 65
Dependent Claim
36 words
The method of claim 57 , wherein the distal opening of the catheter is moved during the drawing of fluid in a direction such that the distal opening crosses at least a portion of the occlusion.
Claim 66
Dependent Claim
23 words
The method of claim 57 , wherein the emboli are carried through said lumen of said catheter in a distal to proximal direction.
Claim 67
Dependent Claim
36 words
The method of claim 57 , further comprising, prior to drawing fluid from the vessel into the distal opening, performing therapy on said occlusion, the performing of therapy causing emboli to break off from the occlusion.
Claim 68
Dependent Claim
14 words
The method of claim 57 , wherein the expandable device is an inflatable balloon.
Claim 69
Dependent Claim
13 words
The method of claim 57 , wherein the expandable device is a filter.
Claim 70
Dependent Claim
26 words
The method of claim 57 , wherein the distal opening of the catheter is moved in a distal to proximal direction during the drawing of fluid.
Claim 71
Dependent Claim
26 words
The method of claim 57 , wherein the distal opening of the catheter is moved in a proximal to distal direction during the drawing of fluid.
Claim 72
Dependent Claim
40 words
The method of claim 65 , wherein the distal opening of the catheter is moved in a proximal to distal direction after moving the distal opening of the catheter in a distal to proximal direction during the drawing of fluid.
Claim 73
Dependent Claim
29 words
The method of claim 57 , wherein the distal opening of the catheter is moved over a distance of about 10 cm or more during the drawing of fluid.
Claim 74
Dependent Claim
24 words
The method of claim 57 , wherein the distal opening of the catheter is moved repeatedly across the occlusion during the drawing of fluid.
References Cited (Backward Citations)
US3144868A
Cited
US4276874A
Cited
US4511354A
Cited
US4456011A
Cited
US4573966A
Cited
US4610662A
Cited
US4636195A
Cited
US4445892A
Cited
US4468216A
Cited
US4714460A
Cited
US4692139A
Cited
US4705507A
Cited
US4926858A
Cited
US4790813A
Cited
US4824436A
Cited
US4696668A
Cited
US4781677A
Cited
US5449343A
Cited
US4790812A
Cited
US4655746A
Cited
US4911163A
Cited
US4748982A
Cited
US5496346A
Cited
DE3804849A1
Cited
US4832028A
Cited
US5000743A
Cited
US5152277A
Cited
WO1989001309A1
Cited
US4921478A
Cited
US4838268A
Cited
US4950238A
Cited
US5059178A
Cited
US5163906A
Cited
US5035686A
Cited
US4946466A
Cited
US4964409A
Cited
US5423742A
Cited
US5195955A
Cited
US5460610A
Cited
US5163905A
Cited
US5328471A
Cited
US5135484A
Cited
US5395311A
Cited
US5279546A
Cited
US5226889A
Cited
US5320604A
Cited
US5167239A
Cited
US5221270A
Cited
US5645533A
Cited
US5413558A
Cited
US5505702A
Cited
US5458573A
Cited
US5250060A
Cited
US5415635A
Cited
US5500180A
Cited
US5439000A
Cited
US5281200A
Cited
US5423744A
Cited
US5256141A
Cited
US5320605A
Cited
US5403274A
Cited
US5322508A
Cited
US5342306A
Cited
US5464394A
Cited
US5599307A
Cited
US5405322A
Cited
US5380284A
Cited
WO1995009024A1
Cited
US5462529A
Cited
US5634897A
Cited
US5476450A
Cited
US5397307A
Cited
US5458574A
Cited
US5415636A
Cited
US5484412A
Cited
US5478309A
Cited
US5505700A
Cited
US5439446A
Cited
WO1996001079A1
Cited
US5514092A
Cited
WO1996015824A1
Cited
US5827229A
Cited
US5833650A
Cited
US5674198A
Cited
US5681336A
Cited
US5688234A
Cited
US5823996A
Cited
US6022336A
Cited
WO1997044082A2
Cited
US5833644A
Cited
US6152909A
Cited
US6309399B1
Cited
US5779721A
Cited
US5879361A
Cited
WO1998026833A1
Cited
WO1998038930A1
Cited
US6135991A
Cited
WO1998044982A1
Cited
US5954745A
Cited
US5941896A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-09-23 | 2006-03-25 | 2006-09-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-09-23 | 2010-03-25 | 2010-09-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-09-23 | 2014-03-25 | 2014-09-24 | $7700.00 | Window Closed / Lapsed |