US6379690B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Keratin-based hydrogel for biomedical applications and method of production
Assignee: Keraplast Technologies Ltd
•
Filing: 2000-12-12
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Granted: 2002-04-30
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Expires: 2020-12-12
Abstract
Abstract A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.
Inventors
- 👤 Cheryl R. Blanchard
- 👤 Scott F. Timmons
- 👤 Robert A. Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:02
CPC Classifications
C; C08; C08H; C08H1/00; C08H1/06; A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/1703; A61K38/1709; A61K38/39; A61K8/00; A61K8/02; A61K8/04; A61K8/042; A61K8/18; A61K8/30; A61K8/64; A61K8/65; A61L; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0047; A61L26/0061; A61L26/008; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/28; A61L27/34; A61L27/50; A61L27/52; A61L27/60; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/08; A61L31/10; A61Q; A61Q19/00; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4741; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/842
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
22 words
A method of engineering tissue comprising the implantation of a tissue engineering scaffold comprising a keratin hydrogel comprising reformed keratin-to-keratin disulfide links.
Claim 2
Independent Claim
22 words
A method of engineering tissue comprising the implantation of a tissue engineering scaffold comprising a keratin hydrogel comprising reformed keratin-to-keratin disulfide links.
Claim 3
Dependent Claim
16 words
The method of claim 1 , wherein said keratin hydrogel is derived primarily from human hair.
Claim 4
Dependent Claim
28 words
The method of claim 1 , wherein said keratin includes keratin bound together with covalent, disulfide links, and said keratin has ionic groups responsible for the hydrophilic property.
Claim 5
Dependent Claim
24 words
The method of claim 1 , wherein said hydrogel has a concentration in the range of 0.05 to 0.4 grams of keratin per mL.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-04-29 | 2005-10-29 | 2006-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-04-29 | 2009-10-29 | 2010-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-04-29 | 2013-10-29 | 2014-04-30 | $7700.00 | Window Closed / Lapsed |