US6124273A
Expired / Lapsed
US
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Chitin hydrogels, methods of their production and use
Assignee: American Red Cross
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Filing: 1997-10-13
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Granted: 2000-09-26
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Expires: 2017-10-13
Abstract
Abstract This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, this invention provides a composition of matter, comprising a chitin hydrogel or chitin-derived hydrogel, wherein the hydrogel does not inhibit full-thickness skin wound healing.
Inventors
- 👤 William N. Drohan
- 👤 Martin J. MacPhee
- 👤 Shirley I. Miekka
- 👤 Manish S. Singh
- 👤 Clive Elson
- 👤 John R. Taylor, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:03
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/36; A61K38/37; A61K38/43; A61K38/46; A61K38/48; A61K38/482; A61K38/4846; A61K47/00; A61K47/30; A61K47/36; A61K9/00; A61K9/0012; A61K9/0014; A61K9/0019; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61L26/00; A61L26/0009; A61L26/0023; A61L26/0028; A61L26/0047; A61L26/0061; A61L26/0066; A61L26/008; A61P; A61P17/00; A61P7/00; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0024; C08B37/0027; C08B37/003; C08L; C08L5/00; C08L5/08; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/418; A61L2300/45; A61L2300/60; A61L2300/602
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
35 words
A composition of matter that provides sustained release of proteins, said composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having a protein to be delivered incorporated therein in sufficient concentration to provide said sustained release.
Claim 2
Dependent Claim
35 words
A composition of matter that provides sustained release of proteins, said composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having a protein to be delivered incorporated therein in sufficient concentration to provide said sustained release.
Claim 3
Dependent Claim
20 words
The composition of claim 1, wherein said protein is selected from the group consisting of plasma proteins and osteogenic proteins.
Claim 4
Dependent Claim
23 words
The composition of claim 2, wherein said plasma proteins are selected from the group consisting of Factor IX, Factor VIII, and mixtures thereof.
Claim 5
Dependent Claim
13 words
The composition of claim 2, wherein said osteogenic protein comprises bone morphogenic protein.
Claim 6
Dependent Claim
27 words
The composition of claim 4, further comprising a bone growth promoting substance selected from the group consisting of bone marrow cells, bone chips, hydroxyapatite, and mixtures thereof.
Claim 7
Dependent Claim
38 words
The composition of claim 1, further comprising at least one growth factor to be delivered incorporated therein in a sufficient concentration to provide sustained release of said growth factor in addition to the sustained release of said protein.
Claim 8
Independent Claim
42 words
A method of providing sustained release of proteins to a subject by administering to the subject a composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having a protein to be delivered incorporated therein in a sufficient concentration to provide said sustained release.
Claim 9
Independent Claim
42 words
A method of providing sustained release of proteins to a subject by administering to the subject a composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having a protein to be delivered incorporated therein in a sufficient concentration to provide said sustained release.
Claim 10
Dependent Claim
20 words
The method of claim 7, wherein said protein is selected from the group consisting of plasma proteins and osteogenic proteins.
Claim 11
Dependent Claim
23 words
The method of claim 8, wherein said plasma protein is selected from the group consisting of Factor IX, Factor VIII, and mixtures thereof.
Claim 12
Dependent Claim
13 words
The method of claim 7, wherein said subject has a plasma protein deficiency.
Claim 13
Dependent Claim
20 words
The method of claim 10, wherein said disorder is selected from the group consisting of Hemophilia B and Hemophilia A.
Claim 14
Dependent Claim
35 words
The method according to claim 7, wherein said composition further comprises a t least one growth facto r to be delivered incorporated therein in a sufficient concentration to provide sustained release of said growth factor.
Claim 15
Dependent Claim
14 words
The method according to claim 8, wherein said osteogenic protein comprises bone morphogenic protein.
Claim 16
Independent Claim
47 words
A method of promoting wound healing comprising administering to the wound a composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having at least one therapeutically effective protein to be delivered incorporated therein in a sufficient concentration to provide said sustained release of said protein to said wound.
Claim 17
Independent Claim
47 words
A method of promoting wound healing comprising administering to the wound a composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having at least one therapeutically effective protein to be delivered incorporated therein in a sufficient concentration to provide said sustained release of said protein to said wound.
Claim 18
Dependent Claim
29 words
The method according to claim 14, wherein said composition administered to said wound further comprises a resorbable backing selected from the group consisting of proteinaceous substances and carbohydrate-derived substances.
Claim 19
Dependent Claim
23 words
The method according to claim 15, wherein said proteinaceous substances are selected from the group consisting of fibrin, collagen, keratin, and mixtures thereof.
Claim 20
Dependent Claim
12 words
The method according to claim 15, wherein said carbohydrate-derived substance is chitin.
Claim 21
Dependent Claim
17 words
The method according to claim 14, wherein said composition is in the form of an expandable foam.
Claim 22
Dependent Claim
33 words
The method according to claim 14, wherein said composition further comprises at least one growth factor to be delivered incorporated therein in a sufficient concentration to provide sustained delivery of said growth factor.
Claim 23
Dependent Claim
14 words
The method according to claim 19, wherein said wound is in a hard tissue.
Claim 24
Dependent Claim
12 words
The method according to claim 20, wherein said hard tissue is bone.
Claim 25
Dependent Claim
13 words
The method according to claim 21, wherein said protein comprises an osteogenic protein.
Claim 26
Dependent Claim
15 words
The method according to claim 22, wherein said osteogenic protein comprises a bone morphogenic protein.
Claim 27
Dependent Claim
31 words
The method according to claim 23, wherein said composition further comprises a bone growth promoting substance selected from the group consisting of bone marrow cells, bone chips, hydroxyapatite, and mixtures thereof.
Claim 28
Dependent Claim
29 words
A wound dressing composition for treatment of wounded tissue, said composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel; and a resorbable backing consisting essentially of therapeutically effective proteinaceous substances.
Claim 29
Dependent Claim
29 words
A wound dressing composition for treatment of wounded tissue, said composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel; and a resorbable backing consisting essentially of therapeutically effective proteinaceous substances.
Claim 30
Dependent Claim
27 words
The composition according to claim 25, wherein said N,O-carboxymethyl chitosan hydrogel is in the form of a dry material which forms a N,O-carboxymethyl chitosan hydrogel upon hydration.
Claim 31
Dependent Claim
17 words
The composition according to claim 26, wherein said dry material comprises a freeze dried N,O-carboxymethyl chitosan hydrogel.
Claim 32
Dependent Claim
23 words
The composition of claim 25, wherein said proteinaceous substances are selected from the group consisting of fibrin, fibrinogen, collagen, keratin, and mixtures thereof.
Claim 33
Dependent Claim
13 words
The composition according to claim 25, which hydrogel further comprises a growth factor.
Claim 34
Dependent Claim
10 words
The composition of claim 26, further comprising a proteinaceous substance.
Claim 35
Dependent Claim
12 words
The composition of claim 30, wherein said wound is an internal wound.
Claim 36
Dependent Claim
23 words
The composition of claim 30, wherein said proteinaceous substance is selected from the group consisting of fibrin, fibrinogen, collagen, keratin, and mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-09-26 | 2004-03-27 | 2004-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-09-26 | 2008-03-27 | 2008-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-09-26 | 2012-03-27 | 2012-09-26 | $7700.00 | Window Closed / Lapsed |