Patent US4433681A successfully refreshed from Google Patents.
Patent US6165486A successfully refreshed from Google Patents.
US6165486A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible compositions and methods of using same
Assignee: Carnegie Mellon University
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Filing: 1998-11-19
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Granted: 2000-12-26
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Expires: 2018-11-19
Abstract
Abstract Blends of biodegradable polymers, preferably poly(caprolactone) and poly(D,L-lactic-co-glycolic) acid are discussed as well as their applications in the medical field, particularly with regard to bone tissue engineering. Preferably, hydroxyapatite ("HA") granules are incorporated into the blends and the resulting blends have desirable mechanical, physical, and biological characteristics. Even more preferably the compositions of the present invention are utilized to form osteoconductive composites that supported bone cell growth on the surface as well as throughout the scaffold.
Inventors
- 👤 Kacey G. Marra
- 👤 Lee E. Weiss
- 👤 Jay Wynn Calvert
- 👤 Prashant N. Kumta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:37
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
48 words
A composition comprised of: a bioceramic material; a polycaprolactone; and a copolymer of poly(lactic) acid and poly(glycolic) acid; said copolymer and said polycaprolactone blended at a predetermined ratio, said predetermined ratio being in the range of from about 10:90 polycaprolactone to copolymer to about 50:50 polycaprolactone to copolymer.
Claim 2
Dependent Claim
48 words
A composition comprised of: a bioceramic material; a polycaprolactone; and a copolymer of poly(lactic) acid and poly(glycolic) acid; said copolymer and said polycaprolactone blended at a predetermined ratio, said predetermined ratio being in the range of from about 10:90 polycaprolactone to copolymer to about 50:50 polycaprolactone to copolymer.
Claim 3
Dependent Claim
14 words
The composition of claim 1 wherein said composition is suitable as a bone substitute.
Claim 4
Dependent Claim
10 words
The composition of claim 1, further comprising a therapeutic agent.
Claim 5
Dependent Claim
12 words
The composition of claim 1 wherein said bioceramic material is a hydroxyapatite.
Claim 6
Independent Claim
66 words
A method of treating a patient for a boney defect comprising the steps of: mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50; adding a bioceramic material to said blend; molding said blend and said bioceramic into an implant; and implanting said implant into said patient.
Claim 7
Independent Claim
66 words
A method of treating a patient for a boney defect comprising the steps of: mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50; adding a bioceramic material to said blend; molding said blend and said bioceramic into an implant; and implanting said implant into said patient.
Claim 8
Dependent Claim
26 words
The method of claim 5, wherein said implant is selected from the group consisting of a bone prosthesis, a hard tissue implant, and a bone scaffold.
Claim 9
Dependent Claim
10 words
The method of claim 5, wherein said bioceramic is hydroxyapatite.
Claim 10
Dependent Claim
18 words
The composition of claim 1, wherein said copolymer is at a ratio of about 65:35 lactic acid:glycolic acid.
Claim 11
Dependent Claim
10 words
The method of claim 5, wherein said implant is osteoconductive.
Claim 12
Independent Claim
66 words
A method of treating a patient for a cranio-facial defect comprising the steps of: mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50; adding a bioceramic material to said blend; molding said blend and said bioceramic into an implant; and implanting said implant into said patient.
Claim 13
Independent Claim
66 words
A method of treating a patient for a cranio-facial defect comprising the steps of: mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50; adding a bioceramic material to said blend; molding said blend and said bioceramic into an implant; and implanting said implant into said patient.
Claim 14
Independent Claim
68 words
A method of treating a patient in need of a bone substitute comprising the steps of: mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50; adding a bioceramic material to said blend; molding said blend and said bioceramic into an implant; and implanting said implant into said patient.
Claim 15
Independent Claim
68 words
A method of treating a patient in need of a bone substitute comprising the steps of: mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone:copolymer in the range of about 10:90 to about 50:50; adding a bioceramic material to said blend; molding said blend and said bioceramic into an implant; and implanting said implant into said patient.
Claim 16
Dependent Claim
12 words
The method of claim 5, wherein said implant is a prosthetic template.
Claim 17
Dependent Claim
14 words
The method of claim 5, wherein said implant is a template for bone formation.
Claim 18
Dependent Claim
18 words
The method of claim 5, wherein said copolymer is at a ratio of about 65:35 lactic acid:glycolic acid.
Claim 19
Dependent Claim
18 words
The method of claim 10, wherein said copolymer is at a ratio of about 65:35 lactic acid:glycolic acid.
Claim 20
Dependent Claim
18 words
The method of claim 11, wherein said copolymer is at a ratio of about 65:35 lactic acid:glycolic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-12-26 | 2004-06-26 | 2004-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-12-26 | 2008-06-26 | 2008-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-12-26 | 2012-06-26 | 2012-12-26 | $7700.00 | Window Closed / Lapsed |