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US5679723A Expired / Lapsed US ⏱️ 0.0 years remaining

Hard tissue bone cements and substitutes

Assignee: Ethicon Inc
•
Filing: 1996-09-19
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Granted: 1997-10-21
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Expires: 2016-09-19
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Abstract

Abstract Absorbable/resorbable mixtures of aliphatic polyesters of poly(lactide), poly(glycolide), poly(trimethylene carbonate), poly(p-dioxanone) and poly(ε-caprolactone) and calcium containing bone regenerating compounds such as powdered, non-fibrous calcium phosphates are described. The composites when used to manufacture medical devices exhibit improved absorption characteristics and other physical properties.

Inventors

  • 👤 Kevin Cooper
  • 👤 Chao C. Chen
  • 👤 Angelo Scopelianos

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 01:32
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/12; A61L31/125; A61L31/128; A61L24/00; A61L24/001; A61L24/0042; A61L24/0047; A61L24/0073; A61L24/0084; A61L24/0089; A61L27/00; A61L27/28; A61L27/30; A61L27/32; A61L27/40; A61L27/44; A61L27/446; A61L27/46; A61L27/50; A61L27/58; A61L31/08; A61L31/082; A61L31/086; A61L31/127; C; C08; C08J; C08J3/00; C08J3/20; C08J3/203; A61F; A61F2310/00; A61F2310/00389; A61F2310/00592; A61F2310/00796; C08J2367/00; C08J2367/04; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T442/00; Y10T442/20; Y10T442/2861; Y10T442/60; Y10T442/699

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 153 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable component comprising a polymer formed from aliphatic lactone monomers selected from the group consisting of p-dioxanone, trimethylene carbonate, ε-caprolactone, delta-valerolactone, beta-butyrolactone, epsilon-decalactone, 2,5-diketomorpholine, pivalolactone, alpha-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, gamma-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 1,4-dioxan-2-one, 6,8-dioxabicycloctane-7-one, and combinations thereof wherein said polymer has an inherent viscosity of about 0.05 to about 0.5 dL/g and, b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound is selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in the body structure.
Claim 2
Independent Claim 153 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable component comprising a polymer formed from aliphatic lactone monomers selected from the group consisting of p-dioxanone, trimethylene carbonate, ε-caprolactone, delta-valerolactone, beta-butyrolactone, epsilon-decalactone, 2,5-diketomorpholine, pivalolactone, alpha-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, gamma-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 1,4-dioxan-2-one, 6,8-dioxabicycloctane-7-one, and combinations thereof wherein said polymer has an inherent viscosity of about 0.05 to about 0.5 dL/g and, b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound is selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in the body structure.
Claim 3
Dependent Claim 216 words
A method of delivering a medical device to a body structure, comprising: loading a liquid, low melt, injectable biocompatible composite into a delivery device, the composite comprising: a) a first absorbable phase comprising a polymer formed from aliphatic lactone monomers selected from the group consisting of p-dioxanone, trimethylene carbonate, ε-caprolactone, delta-valerolactone, beta-butyrolactone, epsilon-decalactone, 2,5-diketomorpholine , pivalolactone, alpha, alpha-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, gamma-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 1,4-dioxan-2-one, 6,8-dioxabicycloctane-7-one, and copolymers, and blends thereof, wherein said polymer has an inherent viscosity of about 0.05 to about 0.5 dL/g, and b) a second resorbable phase comprising a hard tissue osteoconductive or osteoinductive calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di, octa, α-tri, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof, wherein the calcium containing compound has a particle size of about 100 microns to 500 microns and wherein the composite contains about 10 wt. % to about 50 wt. % of the second resorbable phase; and injecting the composite to a body structure, wherein the polymer of the composite of claim 1 has an inherent viscosity of about 0.05 to about 0.5 dL/g, such that the composite can easily flow, with or without the application of heat, through the delivery device to a body structure.
Claim 4
Independent Claim 136 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable component comprising a polymer selected from the group consisting of poly(p-dioxanone-co-glycolide), poly(trimethylene carbonate-co-glycolide), poly(ε-caprolactone-co-glycolide), poly(p-dioxanone-co-lactide), and poly(trimethylene carbonate-co-lactide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in a body structure.
Claim 5
Independent Claim 136 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable component comprising a polymer selected from the group consisting of poly(p-dioxanone-co-glycolide), poly(trimethylene carbonate-co-glycolide), poly(ε-caprolactone-co-glycolide), poly(p-dioxanone-co-lactide), and poly(trimethylene carbonate-co-lactide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in a body structure.
Claim 6
Independent Claim 128 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable phase comprising a polymer selected from the group consisting of poly(p-dioxanone-co-glycolide), poly(trimethylene carbonate-co-glycolide), poly(ε-caprolactone-co-glycolide), poly(p-dioxanone-co-lactide), and poly(trimethylene carbonate-co-lactide), and blends thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable phase comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof.
Claim 7
Independent Claim 128 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable phase comprising a polymer selected from the group consisting of poly(p-dioxanone-co-glycolide), poly(trimethylene carbonate-co-glycolide), poly(ε-caprolactone-co-glycolide), poly(p-dioxanone-co-lactide), and poly(trimethylene carbonate-co-lactide), and blends thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable phase comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof.
Claim 8
Independent Claim 135 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt biocompatible composite, comprising: a) a first absorbable component comprising a mixture of homopolymers selected from the group consisting of poly(p-dioxanone), poly(trimethylene carbonate), poly(ε-caprolactone) and poly(glycolide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in the body structure.
Claim 9
Independent Claim 135 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt biocompatible composite, comprising: a) a first absorbable component comprising a mixture of homopolymers selected from the group consisting of poly(p-dioxanone), poly(trimethylene carbonate), poly(ε-caprolactone) and poly(glycolide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in the body structure.
Claim 10
Independent Claim 136 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable component comprising a mixture of homopolymers selected from the group consisting of poly(p-dioxanone), poly(trimethylene carbonate), poly(ε-caprolactone) and poly(lactide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in the body structure.
Claim 11
Independent Claim 136 words
A method of conforming a medical device to a body structure, comprising: injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises: a liquid, low melt, injectable biocompatible composite, comprising: a) a first absorbable component comprising a mixture of homopolymers selected from the group consisting of poly(p-dioxanone), poly(trimethylene carbonate), poly(ε-caprolactone) and poly(lactide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, α-tri-, β-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and, implanting the device in the body structure.

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