US5679658A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N,O-carbonxymethylchitosan for prevention of surgical adhesions
Assignee: Kytogenics Pharmaceuticals Ltd
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Filing: 1995-05-08
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Granted: 1997-10-21
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Expires: 2015-05-08
Abstract
Abstract The invention relates to a method of treating patients to minimize post-surgical adhesions and a kit useful in the method of the invention. The method is based on the timing that N,O-carboxymethylchitosan (NOCC) has advantageous properties as a wound healing lavage and coating. A NOCC solution is particularly effective as a post-surgical lavage and when used in conjunction with a NOCC gel coating, wound healing rate is unchanged while the number and severity of adhesions in greatly reduced.
Inventors
- 👤 Clive M. Elson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:31
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0009; A61L26/0023; A61K; A61K31/00; A61K31/70; A61K31/715; A61K31/716; A61K31/722; A61L31/00; A61L31/04; A61L31/042; A61P; A61P41/00; A61P43/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
54 words
A method of reducing post-surgical adhesions in a surgical patient comprising the sequential steps of (1) coating of a surgical site with an effective amount of a covalently crosslinked N,O-carboxymethylchitosan gel post-suturing, and (2) post-surgical lavage of said surgical site with a solution containing an effective amount of N,O-carboxymethylchitosan in a pharmaceutically acceptable carrier.
Claim 2
Independent Claim
54 words
A method of reducing post-surgical adhesions in a surgical patient comprising the sequential steps of (1) coating of a surgical site with an effective amount of a covalently crosslinked N,O-carboxymethylchitosan gel post-suturing, and (2) post-surgical lavage of said surgical site with a solution containing an effective amount of N,O-carboxymethylchitosan in a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
26 words
The method of claim 1 wherein said effective amount of N,O-carboxymethylchitosan in said post-surgical lavage solution is about 100-300 mg/kg of said surgical patient's body weight.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein said post-surgical lavage solution comprises 0.5-4% by weight N,O-carboxymethylchitosan.
Claim 5
Dependent Claim
15 words
The method of claim 3 wherein said post-surgical lavage solution comprises 1-3% by weight N,O-carboxymethylchitosan.
Claim 6
Dependent Claim
30 words
The method of claim 1 wherein said pharmaceutically acceptable carrier for said post-surgical lavage solution is selected from the group consisting of water, saline, phosphate buffered saline, and mixtures thereof.
Claim 7
Dependent Claim
16 words
The method of claim 1 wherein said covalently cross-linked N,O-carboxymethylchitosan gel comprises 0.1-3% N,O-carboxymethylchitosan by weight.
Claim 8
Dependent Claim
16 words
The method of claim 6 wherein said covalently cross-linked N,O-carboxymethylchitosan gel comprises 0.5-1.5% N,O-carboxymethylchitosan by weight.
Claim 9
Dependent Claim
26 words
The method of claim 1 further comprising the step of pre-surgical lavage with a solution containing an effective amount of N,O-carboxymethylchitosan in a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
24 words
The method of claim 8 wherein said effective amount of N,O-carboxymethylchitosan in said pre-surgical lavage is 100-300 mg/kg of said surgical patient's body weight.
Claim 11
Dependent Claim
15 words
The method of claim 8 wherein said pre-surgical lavage solution comprises 0.5-4% N,O-carboxymethylchitosan by weight.
Claim 12
Dependent Claim
15 words
The method of claim 10 wherein said pre-surgical lavage solution comprises 1-3% N,O-carboxymethylchitosan by weight.
Claim 13
Dependent Claim
29 words
The method of claim 8 wherein said pharmaceutically acceptable carrier for said pre-surgical lavage is selected from the group consisting of water, saline, phosphate buffered saline, and mixtures thereof.
Claim 14
Dependent Claim
54 words
A kit for post-surgical lavage of surgical incisions so as to reduce adhesions comprising a sterile 0.5-4% by weight solution of N,O-carboxymethylchitosan in a pharmaceutically acceptable carrier and a sterile gel for treating said surgical incisions prior to using the post-surgical lavage solution, said sterile gel comprising 0.1-3% by weight of covalently crosslinked, N,O-carboxymethylchitosan.
Claim 15
Dependent Claim
54 words
A kit for post-surgical lavage of surgical incisions so as to reduce adhesions comprising a sterile 0.5-4% by weight solution of N,O-carboxymethylchitosan in a pharmaceutically acceptable carrier and a sterile gel for treating said surgical incisions prior to using the post-surgical lavage solution, said sterile gel comprising 0.1-3% by weight of covalently crosslinked, N,O-carboxymethylchitosan.
Claim 16
Dependent Claim
25 words
The kit of claim 13 wherein said pharmaceutically acceptable carrier is selected from the group consisting of water, saline, phosphate buffered saline, and mixtures thereof.
Claim 17
Dependent Claim
35 words
The kit of claim 13 further containing a sterile surgical gel for treating said surgical incisions prior to using the post-surgical lavage solution, said surgical gel comprising 0.1-10% by weight of a non-covalently complexed N,O-carboxymethylchitosan.
References Cited (Backward Citations)
US4141973A
Cited
US4141973B1
Cited
US4886787A
Cited
US4619995A
Cited
US4819617A
Cited
US5080893A
Cited
US5140016A
Cited
US5023090A
Cited
US5093319A
Cited
US5462990A
Cited
WO1993013137A1
Cited
US5411988A
Cited
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