US6042559A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Insulated catheter for selective organ perfusion
Assignee: Zoll Circulation Inc
•
Filing: 1998-02-24
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Granted: 2000-03-28
•
Expires: 2018-02-24
Abstract
Abstract A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues, by perfusion of the organ with blood cooled externally from the body of the patient. A flexible supply catheter is inserted percutaneously into an artery. Blood from the supply catheter is cooled in a finned tube heat exchanger or a fluid bath. A flexible delivery catheter is inserted percutaneously through the vascular system of the patient to place the distal end of the catheter in an artery feeding the selected organ. An occlusion device is expanded to occlude the feeder artery at a point proximal to the distal end of the delivery catheter. Cooled blood from the chiller is pumped through the delivery catheter to an outlet near the distal end of the catheter, to cool the selected organ, distal to the tip of the delivery catheter.
Inventors
- 👤 John D. Dobak, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:45
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/369; A61B; A61B18/00; A61B2018/00053; A61B2018/00166; A61M2205/00; A61M2205/36; A61M2205/3633; A61M2205/366
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
159 words
An apparatus for selective organ hypothermia by perfusion, said apparatus comprising: a chiller; a flexible elongated supply catheter, said supply catheter having a proximal end attachable to an inlet of said chiller, said supply catheter having a distal end percutaneously insertable into an artery of a patient; a flexible elongated delivery catheter, said delivery catheter having a proximal end attachable to an outlet of said chiller, said delivery catheter having sufficient length and sufficiently small diameter to be insertable percutaneously through a vascular system of a patient to a feeder artery of a selected organ of a patient, said delivery catheter having a lumen for flow of cooled blood from said chiller to a feeder artery of a selected organ of a patient; an insulating layer in said delivery catheter between said blood lumen and the outer surface of said delivery catheter; and a blood outlet formed in said blood lumen, near a distal end of said delivery catheter.
Claim 2
Independent Claim
159 words
An apparatus for selective organ hypothermia by perfusion, said apparatus comprising: a chiller; a flexible elongated supply catheter, said supply catheter having a proximal end attachable to an inlet of said chiller, said supply catheter having a distal end percutaneously insertable into an artery of a patient; a flexible elongated delivery catheter, said delivery catheter having a proximal end attachable to an outlet of said chiller, said delivery catheter having sufficient length and sufficiently small diameter to be insertable percutaneously through a vascular system of a patient to a feeder artery of a selected organ of a patient, said delivery catheter having a lumen for flow of cooled blood from said chiller to a feeder artery of a selected organ of a patient; an insulating layer in said delivery catheter between said blood lumen and the outer surface of said delivery catheter; and a blood outlet formed in said blood lumen, near a distal end of said delivery catheter.
Claim 3
Dependent Claim
19 words
An apparatus as recited in claim 1, wherein said insulating layer comprises an annular space surrounding said blood lumen.
Claim 4
Dependent Claim
14 words
An apparatus as recited in claim 2, wherein said annular space contains a vacuum.
Claim 5
Dependent Claim
22 words
An apparatus as recited in claim 3, further comprising a vacuum device connected to said annular space for actively maintaining said vacuum.
Claim 6
Dependent Claim
18 words
An apparatus as recited in claim 2, wherein said annular space contains a material of low thermal conductivity.
Claim 7
Dependent Claim
36 words
An apparatus as recited in claim 1, wherein said insulating layer comprises a plurality of longitudinal channels in a wall of said delivery catheter, said longitudinal channels being arranged parallel to, and surrounding, said blood lumen.
Claim 8
Dependent Claim
15 words
An apparatus as recited in claim 6, wherein each said longitudinal channel contains a vacuum.
Claim 9
Dependent Claim
24 words
An apparatus as recited in claim 7, further comprising a vacuum device connected to said plurality of longitudinal channels for actively maintaining said vacuum.
Claim 10
Dependent Claim
19 words
An apparatus as recited in claim 6, wherein each said longitudinal channel contains a material of low thermal conductivity.
Claim 11
Dependent Claim
43 words
An apparatus as recited in claim 1, further comprising an occlusion device adjacent said distal end of said delivery catheter, said occlusion device being selectively expandable to occlude the feeder artery of the selected organ, at a point proximal to said blood outlet.
Claim 12
Dependent Claim
23 words
An apparatus as recited in claim 10, wherein said occlusion device comprises a selectively expandable and retractable membrane mounted on said delivery catheter.
Claim 13
Dependent Claim
18 words
An apparatus as recited in claim 11, wherein said expandable membrane comprises a selectively inflatable and deflatable balloon.
Claim 14
Dependent Claim
29 words
An apparatus as recited in claim 1, further comprising a pump connected to said supply catheter to pump blood through said supply catheter, said chiller, and said delivery catheter.
Claim 15
Dependent Claim
16 words
An apparatus as recited in claim 1, wherein said chiller comprises a finned tube heat exchanger.
Claim 16
Dependent Claim
18 words
An apparatus as recited in claim 1, wherein said chiller comprises a coil immersed in a fluid bath.
Claim 17
Independent Claim
209 words
An apparatus for selective organ hypothermia by perfusion, said apparatus comprising: a chiller; a flexible elongated supply catheter, said supply catheter having a proximal end connected in fluid flow communication with an inlet of said chiller, said supply catheter having a distal end percutaneously insertable into an artery of a patient; a pump connected to said supply catheter; a flexible elongated delivery catheter, said delivery catheter having a proximal end connected in fluid flow communication with an outlet of said chiller, said delivery catheter having sufficient length and sufficiently small diameter to be insertable percutaneously through a vascular system of a patient to a feeder artery of a selected organ of a patient, said delivery catheter having a lumen for flow of cooled blood from said chiller to a feeder artery of a selected organ of a patient; an insulating layer in said delivery catheter between said blood lumen and the outer surface of said delivery catheter; a blood outlet formed in said blood lumen, near a distal end of said delivery catheter; and an occlusion device formed on said distal end of said delivery catheter, said occlusion device being selectively expandable to occlude the feeder artery of the selected organ, at a point proximal to said blood outlet.
Claim 18
Independent Claim
209 words
An apparatus for selective organ hypothermia by perfusion, said apparatus comprising: a chiller; a flexible elongated supply catheter, said supply catheter having a proximal end connected in fluid flow communication with an inlet of said chiller, said supply catheter having a distal end percutaneously insertable into an artery of a patient; a pump connected to said supply catheter; a flexible elongated delivery catheter, said delivery catheter having a proximal end connected in fluid flow communication with an outlet of said chiller, said delivery catheter having sufficient length and sufficiently small diameter to be insertable percutaneously through a vascular system of a patient to a feeder artery of a selected organ of a patient, said delivery catheter having a lumen for flow of cooled blood from said chiller to a feeder artery of a selected organ of a patient; an insulating layer in said delivery catheter between said blood lumen and the outer surface of said delivery catheter; a blood outlet formed in said blood lumen, near a distal end of said delivery catheter; and an occlusion device formed on said distal end of said delivery catheter, said occlusion device being selectively expandable to occlude the feeder artery of the selected organ, at a point proximal to said blood outlet.
Claim 19
Independent Claim
180 words
A method for selective organ hypothermia by perfusion, said method comprising: providing a chiller, a flexible supply catheter connected to an inlet of said chiller, and a flexible delivery catheter connected to an outlet of said chiller, said delivery catheter having a blood lumen, an insulating layer around said lumen, and a blood outlet adjacent its distal end; percutaneously inserting a distal end of said supply catheter into an artery of a patient; percutaneously inserting a distal end of said delivery catheter into an easily accessible artery near the skin of the patient; passing said delivery catheter through the vascular system of the patient to place said distal end of said delivery catheter in a feeder artery of a selected organ; flowing blood from the supply artery through said supply catheter, said chiller, and said delivery catheter, to the feeder artery of the selected organ; and cooling blood flowing through said chiller, and maintaining the blood flow in said delivery catheter at a lowered temperature, to enable said blood to flow distally into the selected organ and cool the organ.
Claim 20
Independent Claim
180 words
A method for selective organ hypothermia by perfusion, said method comprising: providing a chiller, a flexible supply catheter connected to an inlet of said chiller, and a flexible delivery catheter connected to an outlet of said chiller, said delivery catheter having a blood lumen, an insulating layer around said lumen, and a blood outlet adjacent its distal end; percutaneously inserting a distal end of said supply catheter into an artery of a patient; percutaneously inserting a distal end of said delivery catheter into an easily accessible artery near the skin of the patient; passing said delivery catheter through the vascular system of the patient to place said distal end of said delivery catheter in a feeder artery of a selected organ; flowing blood from the supply artery through said supply catheter, said chiller, and said delivery catheter, to the feeder artery of the selected organ; and cooling blood flowing through said chiller, and maintaining the blood flow in said delivery catheter at a lowered temperature, to enable said blood to flow distally into the selected organ and cool the organ.
Claim 21
Dependent Claim
49 words
A method as recited in claim 17, further comprising providing a pump attached to said supply catheter, and wherein said flowing of blood comprises pumping of blood from the supply artery through said supply catheter, said chiller, and said delivery catheter, to the feeder artery of the selected organ.
Claim 22
Dependent Claim
44 words
A method as recited in claim 17, further comprising: providing an occlusion device adjacent said distal end of said delivery catheter at a point proximal to said blood outlet; and selectively expanding said occlusion device to occlude the feeder artery of the selected organ.
Claim 23
Independent Claim
107 words
A method for selective organ hypothermia by perfusion, said method comprising: providing a supply catheter and a flexible insulated delivery catheter; introducing a distal end of said supply catheter into an artery of a patient; introducing said insulated catheter into the vascular system of a patient to place a distal end of said insulated catheter in a feeding artery of an organ of the patient; withdrawing blood from said patient through said supply catheter; cooling said blood in a chiller; delivering said cooled blood to said feeding artery via said insulated delivery catheter; and cooling said organ by flow of said cooled blood through said feeding artery.
Claim 24
Independent Claim
107 words
A method for selective organ hypothermia by perfusion, said method comprising: providing a supply catheter and a flexible insulated delivery catheter; introducing a distal end of said supply catheter into an artery of a patient; introducing said insulated catheter into the vascular system of a patient to place a distal end of said insulated catheter in a feeding artery of an organ of the patient; withdrawing blood from said patient through said supply catheter; cooling said blood in a chiller; delivering said cooled blood to said feeding artery via said insulated delivery catheter; and cooling said organ by flow of said cooled blood through said feeding artery.
Claim 25
Independent Claim
107 words
A method for selective brain hypothermia by perfusion, said method comprising: providing a supply catheter and a flexible insulated delivery catheter; introducing a distal end of said supply catheter into an artery of a patient; introducing said insulated catheter into the vascular system of a patient to place a distal end of said insulated catheter in a carotid artery of the patient; withdrawing blood from said patient through said supply catheter; cooling said blood in a chiller; delivering said cooled blood to said carotid artery via said insulated delivery catheter; and cooling the brain of the patient by flow of said cooled blood through said carotid artery.
Claim 26
Independent Claim
107 words
A method for selective brain hypothermia by perfusion, said method comprising: providing a supply catheter and a flexible insulated delivery catheter; introducing a distal end of said supply catheter into an artery of a patient; introducing said insulated catheter into the vascular system of a patient to place a distal end of said insulated catheter in a carotid artery of the patient; withdrawing blood from said patient through said supply catheter; cooling said blood in a chiller; delivering said cooled blood to said carotid artery via said insulated delivery catheter; and cooling the brain of the patient by flow of said cooled blood through said carotid artery.
Claim 27
Independent Claim
115 words
A method for selective hypothermia of the heart of a patient, by perfusion, said method comprising: providing a supply catheter and a flexible insulated delivery catheter; introducing a distal end of said supply catheter into an artery of a patient; introducing said insulated catheter into the vascular system of a patient to place a distal end of said insulated catheter in a feeding artery of the heart of the patient; withdrawing blood from said patient through said supply catheter; cooling said blood in a chiller; delivering said cooled blood to said feeding artery via said insulated delivery catheter; and cooling the heart of the patient by flow of said cooled blood through said feeding artery.
Claim 28
Independent Claim
115 words
A method for selective hypothermia of the heart of a patient, by perfusion, said method comprising: providing a supply catheter and a flexible insulated delivery catheter; introducing a distal end of said supply catheter into an artery of a patient; introducing said insulated catheter into the vascular system of a patient to place a distal end of said insulated catheter in a feeding artery of the heart of the patient; withdrawing blood from said patient through said supply catheter; cooling said blood in a chiller; delivering said cooled blood to said feeding artery via said insulated delivery catheter; and cooling the heart of the patient by flow of said cooled blood through said feeding artery.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-03-28 | 2003-09-27 | 2004-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-03-28 | 2007-09-27 | 2008-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-03-28 | 2011-09-27 | 2012-03-28 | $7700.00 | Window Closed / Lapsed |