US5964807A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions and methods for intervertebral disc reformation
Assignee: University of Pennsylvania
•
Filing: 1996-08-08
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Granted: 1999-10-12
•
Expires: 2016-08-08
Abstract
Abstract Methods of reforming degenerated intervertebral discs are provided in accordance with methods of the invention. Hybrid materials useful in methods of the present invention are also provided.
Inventors
- 👤 Jean Chin Chin Gan
- 👤 Paul Ducheyne
- 👤 Edward Vresilovic
- 👤 Irving Shapiro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:53
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3804; A61L27/3817; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/44; A61F2/442; A61L27/02; A61L27/025; A61L27/14; A61L27/18; A61L27/28; A61L27/30; A61L27/306; A61L27/3839; A61L27/3843; A61L27/3852; A61L27/3856; A61L27/3895; A61L27/40; A61L27/44; A61L27/50; A61L27/56; A61F2/30767; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/3011; A61F2002/30182; A61F2002/30187; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0002; A61F2230/0028; A61F2230/0034; A61L2430/00; A61L2430/38
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
49 words
A bioactive substrate comprising a porous polymer foam coated with sol gel bioactive material wherein said sol gel bioactive material penetrates the pores of said polymer foam and at least about 50% of the surface of said polymer foam, which includes the pores, is coated with said sol gel.
Claim 2
Dependent Claim
49 words
A bioactive substrate comprising a porous polymer foam coated with sol gel bioactive material wherein said sol gel bioactive material penetrates the pores of said polymer foam and at least about 50% of the surface of said polymer foam, which includes the pores, is coated with said sol gel.
Claim 3
Dependent Claim
13 words
A bioactive substrate of claim 1 wherein the polymer foam is D,L poly(lactide-co-glycolide).
Claim 4
Dependent Claim
39 words
A bioactive substrate of claim 1 wherein the sol gel bioactive material is comprised of from about 60 to about 100% SiO 2 ; up to about 40% CaO; and up to about 10% P 2 O 5 .
Claim 5
Dependent Claim
28 words
A bioactive substrate of claim 3 wherein the sol gel bioactive material has the nominal composition 70% SiO 2 , 25% CaO, 5% P 2 O 5 .
Claim 6
Dependent Claim
16 words
A bioactive substrate of claim 1 having a pore size of less than about 850 μm.
Claim 7
Dependent Claim
14 words
A bioactive substrate of claim 1 having a percent density less than about 80%.
Claim 8
Dependent Claim
30 words
A hybrid material for reforming degenerated intervertebral disc tissue of a patient comprising a synthetic biodegradable substrate and cells extracted from intervertebral disc tissue, said cells comprising nucleus pulposus cells.
Claim 9
Dependent Claim
30 words
A hybrid material for reforming degenerated intervertebral disc tissue of a patient comprising a synthetic biodegradable substrate and cells extracted from intervertebral disc tissue, said cells comprising nucleus pulposus cells.
Claim 10
Dependent Claim
12 words
The hybrid material of claim 7 wherein the biodegradable substrate is bioactive.
Claim 11
Dependent Claim
20 words
The hybrid material of claim 7 wherein the biodegradable substrate is shaped for surgical insertion into the intervertebral disc space.
Claim 12
Dependent Claim
24 words
The hybrid material of claim 7 wherein the biodegradable substrate is bioactive glass, polymer foam, or polymer foam coated with sol gel bioactive material.
Claim 13
Dependent Claim
15 words
The hybrid material of claim 10 wherein the polymer foam is the copolymer D,L poly(lactide-co-glycolide).
Claim 14
Dependent Claim
15 words
The hybrid material of claim 11 wherein the copolymer comprises 75% polylactide and 25% glycolide.
Claim 15
Dependent Claim
21 words
The hybrid material of claim 10 wherein the substrate is bioactive glass granules of less than about 1000 μm in diameter.
Claim 16
Dependent Claim
19 words
The hybrid material of claim 10 wherein the substrate contains pores with diameters of less than about 850 μm.
Claim 17
Dependent Claim
18 words
The hybrid material of claim 10 wherein the substrate has a percent density of less than about 80%.
Claim 18
Dependent Claim
44 words
The hybrid material of claim 11 wherein the polymer foam is coated with a sol gel bioactive material comprised of from about 60 to about 100% SiO 2 , up to about 40% CaO; and up to about 10% P 2 O 5 .
Claim 19
Dependent Claim
35 words
The hybrid material of claim 12 wherein the polymer foam is coated with a sol gel bioactive material having a nominal composition of 70% SiO 2 , 25% CaO, 5% P 2 O 5 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2002-10-11 | 2003-04-12 | 2003-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-10-11 | 2007-04-12 | 2007-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-10-11 | 2011-04-12 | 2011-10-12 | $7700.00 | Window Closed / Lapsed |