US5336264A
Expired / Lapsed
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Situ prepared calcium phosphate composition and method
Assignee: Norian Corp
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Filing: 1992-07-23
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Granted: 1994-08-09
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Expires: 2012-07-23
Abstract
Abstract Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
Inventors
- 👤 Brent R. Constanz
- 👤 Mark T. Fulmer
- 👤 Bryan M. Barr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:07
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/02; A61K; A61K6/00; A61K6/30; A61K6/50; A61K6/54; A61K6/70; A61K6/71; A61K6/74; A61K6/75; A61K6/80; A61K6/831; A61K6/838; A61K6/849; A61K6/864; A61K6/873; A61K6/876; A61L27/00; A61L27/02; A61L27/12; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/58; C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; C01B25/322; C01B25/327; C01B25/455; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2817; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2210/00; A61F2210/0004; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
100 words
A method for preparing a rapid setting calcium phosphate composition capable of rapidly setting up in a viable mammalian host, said method comprising: combining with mixing dry precursors for producing a calcium phosphate mineral composition, said precursors comprising a calcium source and a phosphoric acid source free of uncombined water; combining said combined precursors with a lubricant at a pH in the range of 6-11, wherein said lubricant comprises a member selected from the group consisting of phosphate and carbonate and is from about 15 to 70 weight percent of the total composition; to form a rapidly setting flowable composition.
Claim 2
Independent Claim
100 words
A method for preparing a rapid setting calcium phosphate composition capable of rapidly setting up in a viable mammalian host, said method comprising: combining with mixing dry precursors for producing a calcium phosphate mineral composition, said precursors comprising a calcium source and a phosphoric acid source free of uncombined water; combining said combined precursors with a lubricant at a pH in the range of 6-11, wherein said lubricant comprises a member selected from the group consisting of phosphate and carbonate and is from about 15 to 70 weight percent of the total composition; to form a rapidly setting flowable composition.
Claim 3
Dependent Claim
46 words
A method according to claim 1, wherein said member selected from the group consisting of phosphate and carbonate is present in said lubricant in a concentration ranging from 0.05 to 0.5M and said pH of said lubricant is in the range of about 7 to 9.
Claim 4
Dependent Claim
13 words
A method according to claim 1, wherein said precursors are milled after combining.
Claim 5
Dependent Claim
28 words
A method according to claim 3, wherein said calcium source comprises at least one of a member selected from the group consisting of tetracalcium phosphate and calcium carbonate.
Claim 6
Dependent Claim
44 words
A method according to claim 1, wherein at least one of said combined precursors and lubricant comprise a protein in an amount equal to from about 0.1 to 5 parts per part by weight as compared with the total weight of calcium phosphate mineral.
Claim 7
Dependent Claim
25 words
A method according to claim 1, wherein said total composition further comprises from about 50 to 90 weight percent of physiologically acceptable particles or aggregate.
Claim 8
Dependent Claim
16 words
A bone tissue comprising ex vivo a composition prepared according to the method of claim 1.
Claim 9
Dependent Claim
26 words
A method for making bone repair, said method comprising: introducing at a bone site for repair, a composition prepared according to the method of claim 1.
Claim 10
Independent Claim
125 words
A method for preparing a rapid setting calcium phosphate composition capable of rapidly setting up in a viable mammalian host, said method comprising: combining with mixing dry precursors for producing a calcium phosphate mineral composition, said precursors comprising a calcium source comprising tetracalcium phosphate and calcium carbonate and a phosphate source comprising at least one of monocalcium phosphate and orthophosphoric acid free of uncombined water; combining said combined precursors with a lubricant comprising a member selected from the group consisting of sodium phosphate and carbonate in a concentration ranging from 0.05 to 0.5M, said lubricant at a pH in the range of 6-11, wherein said lubricant is from about 15 to 70 weight percent of the total composition; a form a rapidly setting flowable composition.
Claim 11
Independent Claim
125 words
A method for preparing a rapid setting calcium phosphate composition capable of rapidly setting up in a viable mammalian host, said method comprising: combining with mixing dry precursors for producing a calcium phosphate mineral composition, said precursors comprising a calcium source comprising tetracalcium phosphate and calcium carbonate and a phosphate source comprising at least one of monocalcium phosphate and orthophosphoric acid free of uncombined water; combining said combined precursors with a lubricant comprising a member selected from the group consisting of sodium phosphate and carbonate in a concentration ranging from 0.05 to 0.5M, said lubricant at a pH in the range of 6-11, wherein said lubricant is from about 15 to 70 weight percent of the total composition; a form a rapidly setting flowable composition.
Claim 12
Dependent Claim
23 words
A method according to claim 9, wherein said lubricant comprises sodium phosphate at a pH in the range of about 7 to 9.
Claim 13
Dependent Claim
13 words
A method according to claim 9, wherein said precursors are milled after combining.
Claim 14
Dependent Claim
16 words
A method according to claim 11, wherein said calcium source comprises tetracalcium phosphate and calcium carbonate.
Claim 15
Dependent Claim
44 words
A method according to claim 9, wherein at least one of said combined precursors and lubricant comprise a protein in an amount equal to from about 0.1 to 5 parts per part by weight as compared with the total weight of calcium phosphate mineral.
Claim 16
Dependent Claim
25 words
A method according to claim 9, wherein said total composition further comprises from about 50 to 90 weight percent of physiologically acceptable particles or aggregate.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1997-08-08 | 1998-02-07 | 1998-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-08 | 2002-02-07 | 2002-08-09 | $3760.00 | Window Closed / Lapsed |
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