US4429691A
Expired / Lapsed
US
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Method for filling in defects or hollow portions of bones
Assignee: Mitsubishi Mining and Cement Co Ltd
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Filing: 1982-01-25
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Granted: 1984-02-07
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Expires: 2002-01-25
Abstract
Abstract A filler for filling in defects or hollow portions of bones to coalesce with the bone tissues is provided which comprises powders of a calcium phosphate compound having the apatite crystalline structure of each crystal grain size of from 50 ∪ to 10 microns and represented by the following general formula of Ca m (PO 4 ) n OH (1.33≦m/n≦1.95); and said powders being adapted for filling in a fluidized or plasticized state. A method of treating a bone with the filler is also provided wherein at least a portion of said filler is filled in to reach the bone-marrow cavity of said bone.
Inventors
- 👤 Shigeo Niwa
- 👤 Kazuhiko Sawai
- 👤 Shinobu Takahashi
- 👤 Hideo Tagai
- 👤 Mikiya Ono
- 👤 Yoshiaki Fukuda
- 👤 Hiroyasu Takeuchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:31
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/42; A61L; A61L27/00; A61L27/02; A61L27/12; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2835; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30084; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
79 words
A method of treating bones with a filler, wherein defects or hollow portions of bones are filled with fluidized or plasticized powders of a calcium phosphate compound having the apatite crystalline structure of each crystal grain size of from 50 Å to 10 microns and represented by the general formula of Ca m (PO 4 ) n OH (1.33≦m/n≦1.95), and wherein at least a portion of said filler is filled in to reach the bone-marrow cavities of said bones.
Claim 2
Independent Claim
79 words
A method of treating bones with a filler, wherein defects or hollow portions of bones are filled with fluidized or plasticized powders of a calcium phosphate compound having the apatite crystalline structure of each crystal grain size of from 50 Å to 10 microns and represented by the general formula of Ca m (PO 4 ) n OH (1.33≦m/n≦1.95), and wherein at least a portion of said filler is filled in to reach the bone-marrow cavities of said bones.
Claim 3
Dependent Claim
19 words
A method as claimed in claim 1, wherein the crystal grain size ranges from 200 Å to 3 microns.
Claim 4
Dependent Claim
47 words
A method as claimed in claim 1, wherein the particle size distribution of said powders of said calcium phosphate compound having the apatite crystalline structure is such that powders each having the particle size of 300 microns or less occupy at least 90% of the total weight.
Claim 5
Dependent Claim
26 words
A method as claimed in claim 3, wherein at least 90% by weight of said powders each have the particle size of 150 microns or less.
Claim 6
Dependent Claim
30 words
A method as claimed in claim 1, wherein said calcium phosphate compound having the apatite crystalline structure is an artificially synthesized compound prepared by a wet, dry or hydrothermal process.
Claim 7
Dependent Claim
35 words
A method as claimed in claim 1, wherein said calcium phosphate compound having the apatite crystalline structure is synthesized by a wet process and calcined at a temperature of from 500° C. to 1100° C.
Claim 8
Dependent Claim
29 words
A method as claimed in claim 1, wherein said calcium phosphate compound having the apatite crystalline structure is sintered at a temperature of from 1100° C. to 1350° C.
Claim 9
Dependent Claim
25 words
A method as claimed in claim 1, wherein said filler is fluidized or plasticized by the addition of water or an isotonic sodium chloride solution.
Claim 10
Dependent Claim
12 words
A method as claimed in claim 1, wherein said filler is granulated.
Claim 11
Dependent Claim
33 words
A method as claimed in claim 9, wherein said granulated filler is sintered at a temperature of from 1100° C. to 1350° C. to form a sintered particle having at least 30% pores.
Claim 12
Dependent Claim
22 words
A method as claimed in claim 10, wherein at least 50% of said pores have the diameters of at least 100 microns.
Claim 13
Dependent Claim
34 words
A method as claimed in claim 9, wherein the granulated filler is sintered and then powders of said calcium phosphate compound having the apatite crystalline structure are added to the granulated filler thus sintered.
Claim 14
Dependent Claim
22 words
A method as claimed in claim 12, wherein the content of said granulated and sintered filler is 30% by weight or less.
Claim 15
Dependent Claim
15 words
A method as claimed in claim 1, wherein cancellous bone is added to said filler.
Claim 16
Dependent Claim
15 words
A method as claimed in claim 14, wherein said cancellous bone is an autoplastic bone.
Claim 17
Dependent Claim
31 words
A method as claimed in claim 14, wherein said cancellous bone is introduced from a foreign source and the amount of said added cancellous bone is 50% by weight or less.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-06 | 1987-08-08 | 1988-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-06 | 1991-08-08 | 1992-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-06 | 1995-08-08 | 1996-02-07 | $7700.00 | Window Closed / Lapsed |