US5908407A — Retroperfusion catheter apparatus and method

Claim 1

Independent Claim 185 words

A catheter for a retroperfusing a venous junction defined by a first vein providing normal blood flow into the junction, and a second and third vein each providing normal blood flow away from the junction, the catheter comprising: an elongate tube having an axis extending between a proximal end and a distal end; portions of the tube defining a plurality of channels, including a through-lumen extending from the proximal end through the distal end of the tube; a first occlusion device disposed in proximity to the distal end of the tube and adapted to at least partially occlude the third vein; a second occlusion device disposed in proximity to the first occlusion device and adapted to at least partially occlude the second vein with the venous junction disposed between the first occlusion device and the second occlusion device; and a retroperfusion lumen included in the channels and having an outlet between the first occlusion device and the second occlusion device, the retroperfusion lumen being adapted to receive arterial blood or pharmacological agents under pressure in order to induce retrograde blood flow in the first vein.

Claim 2

Dependent Claim 185 words

A catheter for a retroperfusing a venous junction defined by a first vein providing normal blood flow into the junction, and a second and third vein each providing normal blood flow away from the junction, the catheter comprising: an elongate tube having an axis extending between a proximal end and a distal end; portions of the tube defining a plurality of channels, including a through-lumen extending from the proximal end through the distal end of the tube; a first occlusion device disposed in proximity to the distal end of the tube and adapted to at least partially occlude the third vein; a second occlusion device disposed in proximity to the first occlusion device and adapted to at least partially occlude the second vein with the venous junction disposed between the first occlusion device and the second occlusion device; and a retroperfusion lumen included in the channels and having an outlet between the first occlusion device and the second occlusion device, the retroperfusion lumen being adapted to receive arterial blood or pharmacological agents under pressure in order to induce retrograde blood flow in the first vein.

Claim 3

Dependent Claim 39 words

The catheter recited in claim 1, further comprising: a pressure lumen included in the channels of the tube, the pressure lumen providing at the proximal end of the tube an indication of the fluid pressure at the venous junction.

Claim 4

Dependent Claim 32 words

The catheter recited in claim 2, further comprising: at least one radiopaque marker carried by the tube and having properties for facilitating placement of the first balloon relative to the venous junction.

Claim 5

Dependent Claim 55 words

The catheter recited in claim 3, further comprising: portions of the tube defining a first port providing fluid communication between the retroperfusion lumen and the venus junction; and portions of the tube defining at least one second port spaced from the first port and providing fluid communication between the retroperfusion lumen and the venus junction.

Claim 6

Dependent Claim 21 words

The catheter recited in claim 4, further comprising portions of the tube defining a soft tip distally of the first balloon.

Claim 7

Dependent Claim 63 words

The catheter recited in claim 5, further comprising: at least one inflation lumen included among the channels of the tube, the at least one inflation lumen providing fluid communication between the proximal end of the tube and at least one of the balloons, for at least partially inflating the at least one balloon in response to the fluid pressure at the venous junction.

Claim 8

Dependent Claim 211 words

A catheter combination for retroperfusing a venous junction defined by a first vein providing normal blood flow into the junction and a second and third vein each providing normal blood flow away from the junction, comprising: an elongate tube having an axis extending between a proximal end and a distal end; portions of the tube defining a plurality of channels including a through-lumen extending from the proximal end of the tube through the distal end of the tube; a first balloon disposed in proximity to the distal end of the tube and adapted to partially occlude the third vein; a second balloon disposed in proximity to the first balloon and adapted to partially occlude the second vein, the first balloon and the second balloon defining an operative region of the tube in proximity to the venous junction; a retroperfusion lumen included among the channels and adapted to provide fluid communication between the proximal end of the tube and the venous junction; and a blood pump providing a flow of arterial blood into the retroperfusion lumen at the proximal end of the tube, the pump having properties for pressurizing the flow of arterial blood at the venous junction so as to produce a retrograde flow of the blood in the first vein.

Claim 9

Dependent Claim 211 words

A catheter combination for retroperfusing a venous junction defined by a first vein providing normal blood flow into the junction and a second and third vein each providing normal blood flow away from the junction, comprising: an elongate tube having an axis extending between a proximal end and a distal end; portions of the tube defining a plurality of channels including a through-lumen extending from the proximal end of the tube through the distal end of the tube; a first balloon disposed in proximity to the distal end of the tube and adapted to partially occlude the third vein; a second balloon disposed in proximity to the first balloon and adapted to partially occlude the second vein, the first balloon and the second balloon defining an operative region of the tube in proximity to the venous junction; a retroperfusion lumen included among the channels and adapted to provide fluid communication between the proximal end of the tube and the venous junction; and a blood pump providing a flow of arterial blood into the retroperfusion lumen at the proximal end of the tube, the pump having properties for pressurizing the flow of arterial blood at the venous junction so as to produce a retrograde flow of the blood in the first vein.

Claim 10

Dependent Claim 93 words

The catheter assembly recited in claim 7 further comprising: a pressure lumen included among the channels of the tube and extending between the proximal end of the tube and the operative region of the tube; portions of the tube defining at least one port in the operative region of the tube, the at least one port providing fluid communication between the retroperfusion lumen and the venous junction; and a pressure transducer disposed in fluid communication with the pressure lumen, the pressure transducer providing an indication of the fluid pressure at the venous junction.

Claim 11

Dependent Claim 63 words

The catheter assembly recited in claim 8, further comprising: at least one inflation lumen included among the channels and extending between the proximal end of the tube and the first balloon; an inflator providing fluid under pressure at the proximal end of the tube, the inflator being adapted to inflate and deflate the first balloon to control the occlusion of the third vein.

Claim 12

Independent Claim 193 words

A method for retroperfusing a venous bed in the brain of a patient, the venous bed communicating with a venous junction defined by a first vein providing antegrade flow into the junction, and second and third veins providing antegrade blood flow away from the junction, the method comprising the steps of: introducing into the second vein a catheter having a first balloon and a second balloon defining an operative region of the catheter, and a plurality of channels including a retroperfusion lumen exiting the catheter in the operative region, and an inflation lumen providing fluid communication with at least the first balloon; positioning the catheter with the first balloon disposed in the third vein and the second balloon disposed in the second vein with the operative region of the catheter disposed in proximity to the venous junction; pressurizing the retroperfusion lumen with arterial blood in order to provide an elevated blood pressure at the venous junction sufficient to induce retrograde blood flow in the first vein; and pressurizing the inflation lumen with a fluid to inflate at least the first balloon in order to control the antegrade blood flow from the venous junction.

Claim 13

Independent Claim 193 words

A method for retroperfusing a venous bed in the brain of a patient, the venous bed communicating with a venous junction defined by a first vein providing antegrade flow into the junction, and second and third veins providing antegrade blood flow away from the junction, the method comprising the steps of: introducing into the second vein a catheter having a first balloon and a second balloon defining an operative region of the catheter, and a plurality of channels including a retroperfusion lumen exiting the catheter in the operative region, and an inflation lumen providing fluid communication with at least the first balloon; positioning the catheter with the first balloon disposed in the third vein and the second balloon disposed in the second vein with the operative region of the catheter disposed in proximity to the venous junction; pressurizing the retroperfusion lumen with arterial blood in order to provide an elevated blood pressure at the venous junction sufficient to induce retrograde blood flow in the first vein; and pressurizing the inflation lumen with a fluid to inflate at least the first balloon in order to control the antegrade blood flow from the venous junction.

Claim 14

Dependent Claim 63 words

The method recited in claim 10 further comprising the steps of: providing a pressure lumen in the catheter; placing a pressure transducer in fluid communication with the pressure lumen, the transducer providing an indication of pressure at the venous junction; and during the second pressurizing step, monitoring the indication of the pressure transducer to control the antegrade blood flow from the venous junction.

Claim 15

Dependent Claim 36 words

The method recited in claim 11 wherein the controlling step further comprises the step of independently controlling the inflation of the first balloon and the second balloon in response to the indication of the pressure transducer.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2002-05-31	2002-11-30	2003-06-01	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2006-05-31	2006-11-30	2007-06-01	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2010-05-31	2010-11-30	2011-06-01	$7700.00	Window Closed / Lapsed

Retroperfusion catheter apparatus and method

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