Patent US5876743A successfully refreshed from Google Patents.
US5876743A
Expired / Lapsed
US
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Biocompatible adhesion in tissue repair
Assignee: Den Mat Holdings LLC
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Filing: 1997-09-22
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Granted: 1999-03-02
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Expires: 2017-09-22
Abstract
Abstract A process for enhancing the (a) normal healing processes involving a live mammalian body of (i) injured non-dental-related soft tissue, and (ii) non-dental-related osseous material, and (b) for enhancing the biocompatibility and adhesion of bone and/or prosthetic device involved in a non-dental surgical or nonsurgical repair procedure, to ossified and non-ossified tissue components with which they are in contact, where there is an injury to either soft or hard tissue or a non-biocompatible prosthesis is placed in the body, that involves placing at the injury or on the prosthesis a) a primary coating that is a tenaciously-bonded hydrophilic water insoluble crosslinked resin coating, b) that optionally contains a measurable amount of a water/fluid leachable fluoride capable of (a) being leached from the coating in a metered amount, and (b) transporting a small amount of leached fluoride from the coating into the afflicted area ("the primary coating with fluoride").
Inventors
- 👤 Robert L. Ibsen
- 👤 William R. Glace
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:20
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61L27/28; A61L27/34; A61F2/32; A61F2/36; A61F2/3607; A61F2/3662; A61F2/3676; A61F2/46; A61F2/4601; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00017; A61F2310/00023; A61L2300/00; A61L2300/10; A61L2300/106; A61L2300/60; A61L2300/606; A61M; A61M25/00; A61M25/10; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/372; A61N1/375; A61N1/37512
Claims Analysis
Total Claims: 61
Claim 1
Independent Claim
36 words
A process for a non-dental-related wound treatment that comprises the step of applying, over a wound, a film or layer of a primary coating that comprises a hydrophilic water insoluble crosslinked resin coating, and, optionally, fluoride.
Claim 2
Dependent Claim
36 words
A process for a non-dental-related wound treatment that comprises the step of applying, over a wound, a film or layer of a primary coating that comprises a hydrophilic water insoluble crosslinked resin coating, and, optionally, fluoride.
Claim 3
Dependent Claim
31 words
The process of claim 1 wherein the primary coating is cured as a thin film on a non-adhesive surface and is put in contact with the wound as a released film.
Claim 4
Dependent Claim
31 words
The process of claim 2, wherein the primary coating is coated on an adhesive receptive surface and cured, and then applied to the wound in the manner of a wound dressing.
Claim 5
Dependent Claim
32 words
A wound dressing comprising a primary coating that comprises a hydrophilic water insoluble crosslinked resin and, optionally, fluoride, that has been coated on an adhesive receptive surface and cured prior to application.
Claim 6
Dependent Claim
32 words
A wound dressing comprising a primary coating that comprises a hydrophilic water insoluble crosslinked resin and, optionally, fluoride, that has been coated on an adhesive receptive surface and cured prior to application.
Claim 7
Dependent Claim
21 words
The wound dressing of claim 4 wherein the adhesive receptive surface is chosen from the group consisting of plastic and cloth.
Claim 8
Dependent Claim
14 words
The wound dressing of claim 5 wherein the adhesive receptive surface is a thermoplastic.
Claim 9
Dependent Claim
12 words
The wound dressing of claim 4 wherein the primary coating comprises fluoride.
Claim 10
Dependent Claim
16 words
The wound dressing of claim 4 wherein the adhesive receptive surface comprises a pressure sensitive adhesive.
Claim 11
Dependent Claim
57 words
A process for the treatment of a wound which comprises applying a wound dressing comprising a primary coating that comprises a hydrophilic water insoluble crosslinked resin and leachable fluoride dispersed therein onto an injured portion of a mammalian body, and allowing the fluoride to be released from the primary coating to contact and penetrate the injured area.
Claim 12
Dependent Claim
57 words
A process for the treatment of a wound which comprises applying a wound dressing comprising a primary coating that comprises a hydrophilic water insoluble crosslinked resin and leachable fluoride dispersed therein onto an injured portion of a mammalian body, and allowing the fluoride to be released from the primary coating to contact and penetrate the injured area.
Claim 13
Dependent Claim
16 words
The process of claim 9, wherein the mammalian body is a human or a domesticated animal.
Claim 14
Dependent Claim
38 words
The process of claim 9, wherein the primary coating is formed from a thermoplastic hydrophilic resin that is water insoluble and the wherein the fluoride source is an inorganic fluoride from which the fluoride is leachable with water.
Claim 15
Dependent Claim
38 words
The process of claim 11, wherein the thermoplastic resin is a linear polymer that contains a hydroscopic group chosen from the group consisting of hydroxyl, carboxylic acid, amide, amine, aliphatic ether, hydroxyalkyl amine, hydroxyalkyl amide, pyrrolidone, and ureyl.
Claim 16
Dependent Claim
17 words
The process of claim 12 wherein the linear polymer comprises polymerized vinyl alcohol, polymerized hydroxyethylmethacrylate, or 2,3-dihydroxypropylacrylate.
Claim 17
Dependent Claim
40 words
The process of claim 13 wherein the linear polymer is chosen from the group consisting of a copolymers of vinyl alcohol and vinyl acetate, copolymers of vinyl alcohol and ethylene, copolymers of vinyl alcohol and acrylic acid, and polyacrylic acid.
Claim 18
Dependent Claim
76 words
In a non-dental-related surgical process wherein a repair is made by adhering one or more bones and/or prosthetic devices to each other and to any contacting soft tissue, the improvement being that the adherence of said bone(s) and/or prosthetic device(s) is accomplished by applying a primary coating comprising a hydrophilic water insoluble crosslinked resin containing both hard and soft crosslinkers and, optionally, fluoride, to one or more of the surfaces of the bone(s) or prosthetic device(s).
Claim 19
Dependent Claim
76 words
In a non-dental-related surgical process wherein a repair is made by adhering one or more bones and/or prosthetic devices to each other and to any contacting soft tissue, the improvement being that the adherence of said bone(s) and/or prosthetic device(s) is accomplished by applying a primary coating comprising a hydrophilic water insoluble crosslinked resin containing both hard and soft crosslinkers and, optionally, fluoride, to one or more of the surfaces of the bone(s) or prosthetic device(s).
Claim 20
Dependent Claim
19 words
The process of claim 15 wherein a primer coating is provided on the surfaces before applying the primary coating.
Claim 21
Dependent Claim
32 words
The process of claim 15 wherein the primary coating contains fluoride that is released in small and safe quantities to the environ of the coating and the surfaces during the healing process.
Claim 22
Dependent Claim
162 words
In a non-dental-related surgical bone repair process comprising (i) incising skin to expose an area in which bone undergoing restoration resides, (ii) exposing the bone undergoing repair, (iii) defining within the exposed area the manner of restoration of the bone, (iv) preparing the area for said restoration, (v) effecting restoration, and (vi) closing the area after completion of the surgical procedure by closing the skin over the area and providing for the natural or aided healing of any wound associated with such procedure, the improvement being that, during said restoration, the following steps are followed in sequence: (v)(a) selecting at least one bone surface within the exposed area that is to be bonded, (v)(b) coating that surface with a primary coating comprising a hydrophilic water insoluble crosslinked resin containing both hard and soft crosslinkers and, optionally, fluoride, (v)(c) contacting the coated surface with bone or a prosthetic device, (v)(d) curing the coating by exposing the coating to light or to ambient temperature.
Claim 23
Dependent Claim
162 words
In a non-dental-related surgical bone repair process comprising (i) incising skin to expose an area in which bone undergoing restoration resides, (ii) exposing the bone undergoing repair, (iii) defining within the exposed area the manner of restoration of the bone, (iv) preparing the area for said restoration, (v) effecting restoration, and (vi) closing the area after completion of the surgical procedure by closing the skin over the area and providing for the natural or aided healing of any wound associated with such procedure, the improvement being that, during said restoration, the following steps are followed in sequence: (v)(a) selecting at least one bone surface within the exposed area that is to be bonded, (v)(b) coating that surface with a primary coating comprising a hydrophilic water insoluble crosslinked resin containing both hard and soft crosslinkers and, optionally, fluoride, (v)(c) contacting the coated surface with bone or a prosthetic device, (v)(d) curing the coating by exposing the coating to light or to ambient temperature.
Claim 24
Dependent Claim
182 words
In a non-dental-related surgical procedure to implant a prosthetic device within a body comprising (i) incising skin to expose an area of the body in which the prosthetic device is to be inserted, (ii) defining within the exposed area the manner of restoration therein by implantation of the prosthetic device, (iii) preparing the area for restoration, (iv) effecting restoration, (v) and closing the area after completion of the surgical procedure by closing the skin over the area and providing for the natural or aided healing of any wound associated with such procedure, the improvement which comprises, during said restoration, the following steps: (iv)(a) selecting at least one prosthetic device surface within the exposed area that is to be bonded, (iv)(b) coating that surface with a primary coating comprising a hydrophilic water insoluble crosslinked resin containing both hard and soft crosslinkers and, optionally, fluoride, (iv)(c) contacting the coated surface with bone and/or tissue, (iv)(d) optionally adding a patch of a cured film of the primary coating with fluoride, and (iv)(e) curing the coating by exposing the coating to light or to ambient temperature.
Claim 25
Dependent Claim
182 words
In a non-dental-related surgical procedure to implant a prosthetic device within a body comprising (i) incising skin to expose an area of the body in which the prosthetic device is to be inserted, (ii) defining within the exposed area the manner of restoration therein by implantation of the prosthetic device, (iii) preparing the area for restoration, (iv) effecting restoration, (v) and closing the area after completion of the surgical procedure by closing the skin over the area and providing for the natural or aided healing of any wound associated with such procedure, the improvement which comprises, during said restoration, the following steps: (iv)(a) selecting at least one prosthetic device surface within the exposed area that is to be bonded, (iv)(b) coating that surface with a primary coating comprising a hydrophilic water insoluble crosslinked resin containing both hard and soft crosslinkers and, optionally, fluoride, (iv)(c) contacting the coated surface with bone and/or tissue, (iv)(d) optionally adding a patch of a cured film of the primary coating with fluoride, and (iv)(e) curing the coating by exposing the coating to light or to ambient temperature.
Claim 26
Dependent Claim
83 words
In a non-dental-related process for aiding in the healing of an open wound or an exposed wound, the improvement which comprises superimposing a cured layer of a primary coating comprising a hydrophilic water insoluble crosslinked resin and fluoride onto the wound such that the tissues at the wound surface are in direct contact with the layer, and maintaining contact between the layer and the wound at least until such time as the wound is essentially closed as a result of the healing process.
Claim 27
Dependent Claim
83 words
In a non-dental-related process for aiding in the healing of an open wound or an exposed wound, the improvement which comprises superimposing a cured layer of a primary coating comprising a hydrophilic water insoluble crosslinked resin and fluoride onto the wound such that the tissues at the wound surface are in direct contact with the layer, and maintaining contact between the layer and the wound at least until such time as the wound is essentially closed as a result of the healing process.
Claim 28
Dependent Claim
61 words
In the process of claim 20 wherein the cured layer of primary coating with fluoride has, on one surface thereof, a layer of uncured primary coating with fluoride, and wherein the uncured primary coating is cured while both it and the cured primary coating are in contact with the wound by exposing the uncured primary coating to light and/or ambient temperature.
Claim 29
Dependent Claim
69 words
A non-dental-related process for repairing an injured or degenerated osseous material which comprises superimposing a patch of a cured layer of a primer coating comprising a hydrophilic water insoluble crosslinked resin with fluoride onto the injured or degenerated area of the osseous material, leaving such patch in contact with the area and allowing growth of the osseous material to encompass the patch and repair the injured or degenerated area.
Claim 30
Dependent Claim
69 words
A non-dental-related process for repairing an injured or degenerated osseous material which comprises superimposing a patch of a cured layer of a primer coating comprising a hydrophilic water insoluble crosslinked resin with fluoride onto the injured or degenerated area of the osseous material, leaving such patch in contact with the area and allowing growth of the osseous material to encompass the patch and repair the injured or degenerated area.
Claim 31
Dependent Claim
62 words
In the process of claim 22 wherein the cured layer of primary coating with fluoride is formed having, one surface thereof, an uncured primary coating with fluoride, and wherein the uncured primary coating is cured while it and the associated cured primary coating are in contact with the area undergoing treatment by exposing the uncured primary coating to light and/or ambient temperature.
Claim 32
Dependent Claim
74 words
A process for enhancing the normal healing processes of injured non-dental-related soft tissue and non-dental-related osseous material, that involves placing at the injury a primary coating that is a hydrophilic water insoluble crosslinked resin coating that optionally contains a measurable amount of a water/fluid leachable fluoride capable of (a) being leached from the coating in a metered amount, and (b) transporting a small amount of leached fluoride from the coating into the afflicted area.
Claim 33
Dependent Claim
74 words
A process for enhancing the normal healing processes of injured non-dental-related soft tissue and non-dental-related osseous material, that involves placing at the injury a primary coating that is a hydrophilic water insoluble crosslinked resin coating that optionally contains a measurable amount of a water/fluid leachable fluoride capable of (a) being leached from the coating in a metered amount, and (b) transporting a small amount of leached fluoride from the coating into the afflicted area.
Claim 34
Dependent Claim
35 words
The process of claim 24 wherein the amount of fluoride provided in the primary coating is insufficient to cause fluorosis of any other toxic reaction, and the fluoride assists the normal processes of wound healing.
Claim 35
Dependent Claim
57 words
The process of claim 24 wherein the primary coating is one layer in a multilayer composite and wherein said composite further comprises a strongly adhesively bonded crosslinkable acrylic resin that rapidly that possesses less hydrophilicity than the primary coating and that cures in situ on an application surface to function as a primer for the primary coating.
Claim 36
Dependent Claim
21 words
The process of claim 24 wherein the resin is based on an ethylenically unsaturated functional monomer that contains a hygroscopic group.
Claim 37
Dependent Claim
17 words
The process of claim 27 wherein the ethylenically unsaturated functional monomer contains hygroscopic groups and exhibits hydrophilicity.
Claim 38
Dependent Claim
13 words
The process of claim 27 wherein the primary coating contains a polycarboxylic acid.
Claim 39
Dependent Claim
15 words
The process of claim 27 wherein the primary coating contains at least one crosslinking agent.
Claim 40
Dependent Claim
20 words
The process of claim 30 wherein the crosslinking agent is a combination of a hard crosslinker and a soft crosslinker.
Claim 41
Dependent Claim
13 words
The process of claim 27 wherein the primary coating contains a coupling agent.
Claim 42
Dependent Claim
12 words
The process of claim 27 wherein the primary coating contains leachable fluoride.
Claim 43
Dependent Claim
90 words
The process of claim 24 wherein the primary coating comprises a two component system that comprises: (a) a first component comprising: (1) a fluoride source including as a particulate siliceous fluoride containing filler in which the fluoride is water leachable; (2) a coupling agent; (3) a photoinitiator or a radiopaquing agent or a buffering agent; and (b) a second component comprising: (1) an ethylenically-unsaturated-functional monomer; (2) a soft crosslinker; (3) a hard crosslinker; (4) a photoinitiator; (5) a polymerized carboxylic acid; (6) a free-radical scavenger; and (7) a curing catalyst.
Claim 44
Dependent Claim
72 words
The process of claim 34 wherein the coupling agent is one or more of (i) N-phenylglycine, the alkali metal salt thereof, or the mixture of the foregoing two compounds, (ii) the adduct of N-(p-tolyl)glycine and glycidyl methacrylate, the alkali metal salt thereof, or the mixture of the foregoing two compounds, and (iii) the adduct of N-phenylglycine and glycidyl methacrylate, the alkali metal salt thereof, or the mixture of the foregoing two compounds.
Claim 45
Dependent Claim
17 words
The process of claim 34 wherein the soft crosslinker is one or more of 2,2-bis(4-methacryloxy-2-ethoxyphenyl)propane, and diethyleneglycol-bis-methacrylate.
Claim 46
Dependent Claim
69 words
The process of claim 34 wherein the hard crosslinker is one or more of (i) the adduct of pyromellitic acid dianhydride and 2-hydroxyethylmethacrylate, (ii) the adduct of 3,3',4,4'-benzophenonetetracarboxylic dianhydride and 2-hydroxyethylmethacrylate, (iii) 4-methacryloxytrimellitic anhydride, and (iv) other compounds containing at least one group or moiety capable of free radical polymerization and at least one aromatic ring or moiety containing electron-withdrawing substituents that do not interfere with free radical polymerization.
Claim 47
Dependent Claim
99 words
A process for enhancing the biocompatibility and adhesion of bone and/or prosthetic devices involved in a non-dental procedure to tissue components with which they are in contact and wherein there is an injury, that involves placing at the injury or on the prosthesis a primary coating that is a hydrophilic water insoluble crosslinked resin coating containing both hard and soft crosslinkers and, optionally, a measurable amount of a water/fluid leachable fluoride capable of (a) being leached from the coating in a metered amount, and (b) transporting a small amount of leached fluoride from the coating into the afflicted area.
Claim 48
Dependent Claim
99 words
A process for enhancing the biocompatibility and adhesion of bone and/or prosthetic devices involved in a non-dental procedure to tissue components with which they are in contact and wherein there is an injury, that involves placing at the injury or on the prosthesis a primary coating that is a hydrophilic water insoluble crosslinked resin coating containing both hard and soft crosslinkers and, optionally, a measurable amount of a water/fluid leachable fluoride capable of (a) being leached from the coating in a metered amount, and (b) transporting a small amount of leached fluoride from the coating into the afflicted area.
Claim 49
Dependent Claim
19 words
The process of claim 38 wherein the prosthesis is made of one or more of metal, ceramic or plastic.
Claim 50
Dependent Claim
35 words
The process of claim 38 wherein the amount of fluoride provided in the primary coating is insufficient to cause fluorosis of any other toxic reaction, and the fluoride assists the normal processes of wound healing.
Claim 51
Dependent Claim
44 words
The process of claim 38 wherein bone and/or prosthetic device surfaces in a non-dental-related surgical procedure, are joined by applying the primary coating or the primary coating with fluoride to bond one or more of the surfaces prior to completion of a surgical repair.
Claim 52
Dependent Claim
57 words
The process of claim 38 wherein the primary coating is one layer in a multilayer composite and wherein said composite further comprises a strongly adhesively bonded crosslinkable acrylic resin that rapidly that possesses less hydrophilicity than the primary coating and that cures in situ on an application surface to function as a primer for the primary coating.
Claim 53
Dependent Claim
24 words
The process of claim 38 wherein the primary coating comprises a resin based on an ethylenically unsaturated functional monomer that contains a hygroscopic group.
Claim 54
Dependent Claim
17 words
The process of claim 43 wherein the ethylenically unsaturated functional monomer contains hygroscopic groups and exhibits hydrophilicity.
Claim 55
Dependent Claim
13 words
The process of claim 43 wherein the primary coating contains a polycarboxylic acid.
Claim 56
Dependent Claim
13 words
The process of claim 43 wherein the primary coating contains a coupling agent.
Claim 57
Dependent Claim
12 words
The process of claim 43 wherein the primary coating contains leachable fluoride.
Claim 58
Dependent Claim
89 words
The process of claim 43 wherein the primary coating comprise a two component system comprising: (a) a first component comprising: (1) a fluoride source including as a particulate siliceous fluoride containing filler in which the fluoride is water leachable; (2) a coupling agent; (3) a photoinitiator or a radiopaquing agent or a buffering agent; and (b) a second component comprising: (1) an ethylenically-unsaturated-functional monomer; (2) a soft crosslinker; (3) a hard crosslinker; (4) a photoinitiator; (5) a polymerized carboxylic acid; (6) a free-radical scavenger; and (7) a curing catalyst.
Claim 59
Dependent Claim
72 words
The process of claim 48 wherein the coupling agent is one or more of (i) N-phenylglycine, the alkali metal salt thereof, or the mixture of the foregoing two compounds, (ii) the adduct of N-(p-tolyl)glycine and glycidyl methacrylate, the alkali metal salt thereof, or the mixture of the foregoing two compounds, and (iii) the adduct of N-phenylglycine and glycidyl methacrylate, the alkali metal salt thereof, or the mixture of the foregoing two compounds.
Claim 60
Dependent Claim
17 words
The process of claim 48 wherein the soft crosslinker is one or more of 2,2-bis(4-methacryloxy-2-ethoxyphenyl)propane, and diethyleneglycol-bis-methacrylate.
Claim 61
Dependent Claim
69 words
The process of claim 48 wherein the hard crosslinker is one or more of (i) the adduct of pyromellitic acid dianhydride and 2-hydroxyethylmethacrylate, (ii) the adduct of 3,3',4,4'-benzophenonetetracarboxylic dianhydride and 2-hydroxyethylmethacrylate, (iii) 4-methacryloxytrimellitic anhydride, and (iv) other compounds containing at least one group or moiety capable of free radical polymerization and at least one aromatic ring or moiety containing electron-withdrawing substituents that do not interfere with free radical polymerization.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2002-03-01 | 2002-08-31 | 2003-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-03-01 | 2006-08-31 | 2007-03-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-03-01 | 2010-08-31 | 2011-03-02 | $7700.00 | Window Closed / Lapsed |