Patent US5744545A successfully refreshed from Google Patents.
US5744545A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible adhesive compositions
Assignee: Surgical Specialties US Corp
•
Filing: 1997-05-08
•
Granted: 1998-04-28
•
Expires: 2017-05-08
Abstract
Abstract Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.
Inventors
- 👤 Woonza M. Rhee
- 👤 Prema R. Rao
- 👤 George H. Chu
- 👤 Frank A. Delustro
- 👤 Carol F. H. Harner
- 👤 Naomi Sakai
- 👤 Jacqueline A. Schroeder
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:47
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/043; A61L31/044; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/61; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/28; A61L27/34; A61L27/40; A61L27/44; A61L27/50; A61L27/54; A61L31/041; A61L31/08; A61L31/10; A61L31/12; A61L31/125; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495; C07K14/78; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0069; C08B37/0072; C08H; C08H1/00; C08H1/06; C08L; C08L89/00; C08L89/04; C08L89/06; C09; C09J; C09J189/00; C09J189/04; C09J189/06; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K38/00; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2430/00; A61L2430/16; C08L2666/00; C08L2666/02; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84; Y10S602/00; Y10S602/904
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
88 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, comprising the steps of: providing collagen and a multifunctionally activated synthetic hydrophilic polymer; mixing the collagen and synthetic polymer to initiate crosslinking between the collagen and the synthetic polymer; applying the mixture of collagen and synthetic polymer to a first surface before substantial crosslinking has occurred between the collagen and the synthetic polymer; and contacting the first surface with a second surface to effect adhesion between the first surface and the second surface.
Claim 2
Independent Claim
88 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, comprising the steps of: providing collagen and a multifunctionally activated synthetic hydrophilic polymer; mixing the collagen and synthetic polymer to initiate crosslinking between the collagen and the synthetic polymer; applying the mixture of collagen and synthetic polymer to a first surface before substantial crosslinking has occurred between the collagen and the synthetic polymer; and contacting the first surface with a second surface to effect adhesion between the first surface and the second surface.
Claim 3
Dependent Claim
19 words
The method of claim 1, wherein at one of the first and second surfaces is a native tissue surface.
Claim 4
Dependent Claim
41 words
The method of claim 1, wherein one of the first and second surfaces is a native tissue surface and the other of the first and second surfaces is selected from a non-native tissue surface and a surface of a synthetic implant.
Claim 5
Dependent Claim
16 words
The method of claim 1, wherein both the first and second surfaces are native tissue surfaces.
Claim 6
Dependent Claim
11 words
The method of claim 1, wherein the collagen is nonfibrillar collagen.
Claim 7
Dependent Claim
33 words
The method of claim 5, wherein the nonfibrillar collagen was prepared by mixing fibrillar collagen with a fiber disassembly agent in an amount sufficient to render the collagen substantially nonfibrillar at pH 7.
Claim 8
Dependent Claim
29 words
The method of claim 6, wherein the fiber disassembly agent is selected from the group consisting of: a biocompatible alcohol, an amino acid, an inorganic salt, and a carbohydrate.
Claim 9
Dependent Claim
24 words
The method of claim 7, wherein the fiber disassembly agent is a biocompatible alcohol selected from the group consisting of glycerol and propylene glycol.
Claim 10
Dependent Claim
14 words
The method of claim 5, wherein the nonfibrillar collagen is a chemically modified collagen.
Claim 11
Dependent Claim
13 words
The method of claim 9, wherein the chemically modified collagen is methylated collagen.
Claim 12
Dependent Claim
26 words
The method of claim 5, wherein the nonfibrillar collagen is selected from the group consisting of: type IV collagen, type VI collagen, and type VII collagen.
Claim 13
Dependent Claim
11 words
The method of claim 1, wherein the collagen is fibrillar collagen.
Claim 14
Dependent Claim
17 words
The method of claim 1, wherein the collagen comprises a mixture of nonfibrillar collagen and fibrillar collagen.
Claim 15
Dependent Claim
20 words
The method of claim 12, wherein the collagen comprises a mixture of particulate crosslinked fibrillar collagen and noncrosslinked fibrillar collagen.
Claim 16
Dependent Claim
14 words
The method of claim 14, wherein the particulate crosslinked fibrillar collagen comprises glutaraldehyde-crosslinked collagen.
Claim 17
Dependent Claim
35 words
The method of claim 14, wherein the particulate crosslinked fibrillar collagen comprises between about 25% to about 95% and the noncrosslinked fibrillar collagen comprises between about 5% to about 75% by weight of the composition.
Claim 18
Dependent Claim
11 words
The method of claim 1, wherein the collagen is denatured collagen.
Claim 19
Independent Claim
92 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, comprising the steps of: providing nonfibrillar collagen and a multifunctionally activated synthetic hydrophilic polymer; mixing the nonfibrillar collagen and synthetic polymer to initiate crosslinking between the nonfibrillar collagen and the synthetic polymer; applying the mixture of nonfibrillar collagen and synthetic polymer to a first surface before substantial crosslinking has occurred between the collagen and the synthetic polymer; and contacting the first surface with a second surface to effect adhesion between the first surface and the second surface.
Claim 20
Independent Claim
92 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, comprising the steps of: providing nonfibrillar collagen and a multifunctionally activated synthetic hydrophilic polymer; mixing the nonfibrillar collagen and synthetic polymer to initiate crosslinking between the nonfibrillar collagen and the synthetic polymer; applying the mixture of nonfibrillar collagen and synthetic polymer to a first surface before substantial crosslinking has occurred between the collagen and the synthetic polymer; and contacting the first surface with a second surface to effect adhesion between the first surface and the second surface.
Claim 21
Dependent Claim
18 words
The method of claim 18, wherein one of the first and second surfaces is a native tissue surface.
Claim 22
Dependent Claim
41 words
The method of claim 18, wherein one of the first and second surfaces is a native tissue surface and the other of the first and second surfaces is selected from a non-native tissue surface and a surface of a synthetic implant.
Claim 23
Dependent Claim
16 words
The method of claim 18, wherein both the first and second surfaces are native tissue surfaces.
Claim 24
Dependent Claim
33 words
The method of claim 18, wherein the nonfibrillar collagen was prepared by mixing fibrillar collagen with a fiber disassembly agent in an amount sufficient to render the collagen substantially nonfibrillar at pH 7.
Claim 25
Dependent Claim
29 words
The method of claim 22, wherein the fiber disassembly agent is selected from the group consisting of: a biocompatible alcohol, an amino acid, an inorganic salt, and a carbohydrate.
Claim 26
Dependent Claim
24 words
The method of claim 23, wherein the fiber disassembly agent is a biocompatible alcohol selected from the group consisting of glycerol and propylene glycol.
Claim 27
Dependent Claim
14 words
The method of claim 18, wherein the nonfibrillar collagen is a chemically modified collagen.
Claim 28
Dependent Claim
13 words
The method of claim 25, wherein the chemically modified collagen is methylated collagen.
Claim 29
Dependent Claim
26 words
The method of claim 18, wherein the nonfibrillar collagen is selected from the group consisting of: type IV collagen, type VI collagen, and type VII collagen.
Claim 30
Independent Claim
84 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, wherein the both of the first surface and the second surface contain nucleophilic groups, said method comprising the steps of: applying a multifunctionally activated synthetic hydrophilic polymer to a first surface; and contacting the first surface with a second surface, whereby the synthetic polymer will covalently bind to nucleophilic groups on the first surface and the second surface to effect adhesion between the first surface and the second surface.
Claim 31
Independent Claim
84 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, wherein the both of the first surface and the second surface contain nucleophilic groups, said method comprising the steps of: applying a multifunctionally activated synthetic hydrophilic polymer to a first surface; and contacting the first surface with a second surface, whereby the synthetic polymer will covalently bind to nucleophilic groups on the first surface and the second surface to effect adhesion between the first surface and the second surface.
Claim 32
Dependent Claim
18 words
The method of claim 28, wherein one of the first and second surfaces is a native tissue surface.
Claim 33
Dependent Claim
41 words
The method of claim 28, wherein one of the first and second surfaces is a native tissue surface and the other of the first and second surfaces is selected from a non-native tissue surface and a surface of a synthetic implant.
Claim 34
Dependent Claim
16 words
The method of claim 28, wherein both the first and second surfaces are native tissue surfaces.
Claim 35
Dependent Claim
18 words
The method of claim 28, wherein the multifunctionally activated synthetic hydrophilic polymer is a multifunctionally activated polyethylene glycol.
Claim 36
Dependent Claim
25 words
The method of claim 32, wherein the multifunctionally activated polyethylene glycol is selected from the group consisting of difunctionally activated SG-PEG and difunctionally activated SE-PEG.
References Cited (Backward Citations)
US4950699A
Cited
US5192316A
Cited
EP0330389A2
Cited
US5024742A
Cited
FR2628634A1
Cited
US5290552A
Cited
EP0341007A2
Cited
US5614587A
Cited
US5475052A
Cited
US5328955A
Cited
US5162430A
Cited
EP0466383A1
Cited
WO1992013578A1
Cited
US5209776A
Cited
US5219895A
Cited
US5354336A
Cited
WO1992013025A1
Cited
US5156613A
Cited
EP0575273A1
Cited
JPH0670972A
Cited
US5549904A
Cited
CA2134744A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-27 | 2001-10-27 | 2002-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-27 | 2005-10-27 | 2006-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-27 | 2009-10-27 | 2010-04-28 | $7700.00 | Window Closed / Lapsed |