US5725568A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and device for recanalizing and grafting arteries
Assignee: Boston Scientific Scimed Inc
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Filing: 1995-06-27
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Granted: 1998-03-10
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Expires: 2015-06-27
Abstract
Abstract The present invention provides an apparatus and method for repairing a diseased vessel at the site of an aneurysm, graft or stenosis. A polymeric self-hardening or self-curing material is introduced into the diseased area. The material is delivered via catheter and allowed to polymerize or cure in situ forming a foam plug in the vessel. A lumen is then created through the foam plug by such means as an atherectomy catheter, to recanalize the vessel. The polymeric material may also be hardened in situ by change in pH or ionic concentration, organic solvents, by permeation of a secondary material capable of precipitation, or by exposure to heat, light or laser energy. In blood, the device may be hardened through a cooperative effect of coagulation, precipitation or ionization. The device can be made of biodegradable material impregnated with growth factors, mitogenic factors or other determinants. The catheter itself may be an ultrasonic imaging catheter.
Inventors
- 👤 Roger N. Hastings
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:07
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12027; A61B17/12036; A61B17/12099; A61B17/12109; A61B17/12113; A61B17/12131; A61B17/12181; A61B17/12186; A61B17/12195; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2/95; A61L; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/50; A61L27/54; A61L27/56; A61B17/00491; A61B17/22; A61B2017/22082; A61F2/94; A61F2/945; A61F2/30; A61F2002/30001; A61F2002/30316; A61F2002/30535; A61F2002/30581; A61F2002/30583; A61F2210/00; A61F2210/0085; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
79 words
A medical device comprising a biocompatible polymeric material which is adapted to be delivered in a first state to a repair site in a vessel, said material being adapted to fill the repair site in its first state and being further adapted to be hardened in situ to form a plug at the repair site, said plug being adapted to have to lumen formed therein in situ, whereby said vessel is recanalized and a polymeric graft is created therein.
Claim 2
Dependent Claim
79 words
A medical device comprising a biocompatible polymeric material which is adapted to be delivered in a first state to a repair site in a vessel, said material being adapted to fill the repair site in its first state and being further adapted to be hardened in situ to form a plug at the repair site, said plug being adapted to have to lumen formed therein in situ, whereby said vessel is recanalized and a polymeric graft is created therein.
Claim 3
Dependent Claim
15 words
The device of claim 1 wherein the polymeric material comprises a self polymerizing polymeric foam.
Claim 4
Dependent Claim
19 words
The device of claim 1 wherein the polymeric material is adapted to be hardened in situ by chemical means.
Claim 5
Dependent Claim
30 words
The device of claim 1 wherein the polymeric material is a moisture curable material selected from the group consisting of cyanoacrylates, polyisocyanates, polyurethane prepolymers, UV curable acrylates, and moisture-curing silicones.
Claim 6
Dependent Claim
13 words
The device of claim 4 wherein the polymeric material further includes bioactive components.
Claim 7
Dependent Claim
31 words
The device of claim 5 wherein the bioactive components are selected from the group consisting of collagen, fibrin, albumin, βFibroblastic Growth Factor, angiogenic factors, RGD adhesion sequences, antibiotics and mixtures thereof.
Claim 8
Dependent Claim
101 words
A medical device comprising a biocompatible polymeric material which is adapted to be delivered in a first state to a repair site in a vessel, said polymeric material comprising an infusion of a solution of a synthetic or biological polymer which precipitates in-vivo, said material being adapted to fill the repair site in its first state and being further adapted to be hardened to form a plug at the repair site, said hardened material being further adapted to have a lumen formed therein, whereby a lumen is formed in said plug, thereby recanalizing file vessel and creating a polymeric graft therein.
Claim 9
Dependent Claim
101 words
A medical device comprising a biocompatible polymeric material which is adapted to be delivered in a first state to a repair site in a vessel, said polymeric material comprising an infusion of a solution of a synthetic or biological polymer which precipitates in-vivo, said material being adapted to fill the repair site in its first state and being further adapted to be hardened to form a plug at the repair site, said hardened material being further adapted to have a lumen formed therein, whereby a lumen is formed in said plug, thereby recanalizing file vessel and creating a polymeric graft therein.
Claim 10
Dependent Claim
17 words
The device of claim 7 wherein the infusion comprises normally insoluble proteins or polysaccharides in non-physiologic solution.
Claim 11
Dependent Claim
18 words
The device of claim 7 wherein the infusion comprises synthetic polymers in a non-aqueous but water miscible solvent.
Claim 12
Independent Claim
59 words
A method for recanalizing and grafting a vessel, the method comprising the steps of: a. providing a polymeric material; b. delivering the polymeric material to a site needing repair in a vessel by means of a catheter, thereby forming a plug in said vessel; and c. canalizing the plug, whereby a stent is formed and the vessel is recanalized.
Claim 13
Independent Claim
59 words
A method for recanalizing and grafting a vessel, the method comprising the steps of: a. providing a polymeric material; b. delivering the polymeric material to a site needing repair in a vessel by means of a catheter, thereby forming a plug in said vessel; and c. canalizing the plug, whereby a stent is formed and the vessel is recanalized.
Claim 14
Dependent Claim
13 words
The method of claim 10 wherein the plug is canalized by catheter means.
Claim 15
Dependent Claim
23 words
The method of claim 11 wherein the catheter means further comprises an atherectomy means and the plug is canalized by said atheterctomy means.
Claim 16
Dependent Claim
126 words
Apparatus for recanalizing and grafting a vessel in a body, the apparatus comprising: a. a source of a biocompatible polymeric material, said material being adapted to be delivered in a first state to a repair site in the vessel, and filling the vessel at the repair site in its first state and being further adapted to be hardened in situ to a second state to form a plug at the repair site; b. a delivery catheter comprising delivery means located therein for delivering said material in its first state to the repair site in the vessel; and c. a second catheter comprising canalizing means located therein for forming a lumen in said material after hardening; whereby a polymeric graft is formed and the vessel is recanalized.
Claim 17
Dependent Claim
126 words
Apparatus for recanalizing and grafting a vessel in a body, the apparatus comprising: a. a source of a biocompatible polymeric material, said material being adapted to be delivered in a first state to a repair site in the vessel, and filling the vessel at the repair site in its first state and being further adapted to be hardened in situ to a second state to form a plug at the repair site; b. a delivery catheter comprising delivery means located therein for delivering said material in its first state to the repair site in the vessel; and c. a second catheter comprising canalizing means located therein for forming a lumen in said material after hardening; whereby a polymeric graft is formed and the vessel is recanalized.
Claim 18
Dependent Claim
11 words
The apparatus of claim 13 wherein the polymeric material is biodegradable.
Claim 19
Dependent Claim
11 words
The apparatus of claim 13 wherein the polymeric material is non-biodegradable.
Claim 20
Dependent Claim
16 words
The apparatus of claim 13 wherein the polymeric material includes growth factors and other mitogenic agents.
Claim 21
Dependent Claim
12 words
The apparatus of claim 13 wherein the polymeric material is self hardening.
Claim 22
Dependent Claim
17 words
The apparatus of claim 13 wherein the polymeric material is adapted to be hardened by chemical means.
Claim 23
Dependent Claim
21 words
The apparatus of claim 13 wherein the polymeric material is adapted to be hardened by means of light or heat energy.
Claim 24
Dependent Claim
26 words
The apparatus of claim 13 wherein the polymeric material is comprised of a material selected from the group consisting of caprolactone, polylactic acid and mixtures thereof.
Claim 25
Dependent Claim
14 words
The apparatus of claim 20 wherein the polymeric material further includes a bioactive material.
Claim 26
Dependent Claim
26 words
The apparatus of claim 13 wherein the polymeric material is delivered through an infusion of a solution of a synthetic or biological polymer which precipitates in-vivo.
Claim 27
Dependent Claim
17 words
The apparatus of claim 22 wherein the infusion comprises normally insoluble proteins or polysaccharides in non-physiologic solution.
Claim 28
Dependent Claim
17 words
The apparatus of claim 22 wherein the infusion comprises synthetic polymers in non-aqueous but water miscible solvent.
References Cited (Backward Citations)
US3808113A
Cited
US4313231A
Cited
US4577631A
Cited
US4822361A
Cited
US4890612A
Cited
US5232444A
Cited
US5059178A
Cited
US5213580A
Cited
US5078726A
Cited
US5328470A
Cited
US5100429A
Cited
US4994033A
Cited
US5112305A
Cited
US5213577A
Cited
US5049132A
Cited
US5328471A
Cited
US5201764A
Cited
US5286254A
Cited
US5279546A
Cited
US5129883A
Cited
US5261875A
Cited
US5320604A
Cited
US5318531A
Cited
US5213576A
Cited
US5254089A
Cited
US5336178A
Cited
US5256141A
Cited
US5314409A
Cited
WO1994021320A1
Cited
US5443495A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-03-09 | 2001-09-08 | 2002-03-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-09 | 2005-09-08 | 2006-03-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-09 | 2009-09-08 | 2010-03-10 | $7700.00 | Window Closed / Lapsed |