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US5718012A
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US
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Method of strength enhancement of collagen constructs
Assignee: Organogenesis Inc
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Filing: 1996-05-28
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Granted: 1998-02-17
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Expires: 2016-05-28
Abstract
Abstract A method for improving the tensile strength of wet collagen threads or collagen thread constructs for implantation to replace or repair tissue or organs wherein the strength of the threads is improved by plasticizing the threads with a plasticizing agent, imparting a tensile load to the collagen thread to strain the collagen thread; allowing the load in the thread to decrease by stress-relaxation or by creep conditioning methods and finally, removing the plasticizing agent. Prosthetic devices comprising collagen threads with improved strength characteristics are intended to repair load bearing tissues such as ligaments and tendons.
Inventors
- 👤 John F. Cavallaro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:52
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61F; A61F2/00; A61F2/0063; A61F2/02; A61F2/08; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
69 words
A method for increasing the strength of at least one collagen thread, comprising: (a) plasticizing a collagen thread with a plasticizing agent; (b) imparting a tensile load to the collagen thread by elongation of said collagen thread to impart a strain on the thread; (c) allowing the load in the thread to decrease substantially by stress-relaxation or by creep; and (d) removing the plasticizing agent from the collagen thread.
Claim 2
Independent Claim
69 words
A method for increasing the strength of at least one collagen thread, comprising: (a) plasticizing a collagen thread with a plasticizing agent; (b) imparting a tensile load to the collagen thread by elongation of said collagen thread to impart a strain on the thread; (c) allowing the load in the thread to decrease substantially by stress-relaxation or by creep; and (d) removing the plasticizing agent from the collagen thread.
Claim 3
Dependent Claim
13 words
The method of claim 1, further comprising the step: (e) crosslinking the thread.
Claim 4
Dependent Claim
14 words
The method of claim 1, wherein the plasticizing agent is water or aqueous buffer.
Claim 5
Dependent Claim
24 words
The method of claim 1, wherein the tensile load is imparted by elongation of the thread to a strain between about 20 to 200%.
Claim 6
Dependent Claim
25 words
The method of claim 1, wherein the tensile load is applied to produce elongation of the thread to a strain between about 50 to 100%.
Claim 7
Dependent Claim
13 words
The method of claim 1, wherein the elongation is done in repeated increments.
Claim 8
Dependent Claim
16 words
The method of claim 6, wherein each increment produces a strain of about 5 to 10%.
Claim 9
Dependent Claim
19 words
The method of claim 1, wherein the load is decreased by stress-relaxation or creep to less than 0.5 grams.
Claim 10
Dependent Claim
44 words
The method of claim 2, wherein the crosslinking is accomplished by lyophilization or ultraviolet (UV) irradiation or by a crosslinking agent selected from the group consisting of acyl-azide, hexamethylene diisocyanate, bisimidates, glyoxal, polyglycerol polyglycidyl ether, adipyl chloride, ribose and other sugars, carbodiimides, and aldehydes.
Claim 11
Dependent Claim
14 words
The method of claim 9, wherein the crosslinking agent is 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC).
Claim 12
Independent Claim
78 words
A method for increasing the strength of a multi-ply bundle of collagen threads, comprising: (a) plasticizing a multi-ply bundle of collagen threads with water, an aqueous buffered solution, or glycerol; (b) imparting a tensile load to said multi-ply bundle by elongating the said bundle to impart a strain on said multi-ply bundle; (c) allowing the load in said multi-ply bundle to decrease substantially by stress-relaxation or by creep; and, (d) removing the plasticizing agent from said multi-ply bundle.
Claim 13
Independent Claim
78 words
A method for increasing the strength of a multi-ply bundle of collagen threads, comprising: (a) plasticizing a multi-ply bundle of collagen threads with water, an aqueous buffered solution, or glycerol; (b) imparting a tensile load to said multi-ply bundle by elongating the said bundle to impart a strain on said multi-ply bundle; (c) allowing the load in said multi-ply bundle to decrease substantially by stress-relaxation or by creep; and, (d) removing the plasticizing agent from said multi-ply bundle.
Claim 14
Dependent Claim
25 words
The method of claim 11, wherein the tensile load is applied to produce elongation of the thread to a strain between about 20 to 200%.
Claim 15
Dependent Claim
25 words
The method of claim 11, wherein the tensile load is applied to produce elongation of the thread to a strain between about 50 to 100%.
Claim 16
Dependent Claim
13 words
The method of claim 11, wherein said elongation is done in repeated increments.
Claim 17
Dependent Claim
18 words
The method of claim 14, wherein the each increment produces a strain of about 5% to about 10%.
Claim 18
Dependent Claim
15 words
The method of claim 11, further comprising the step of: (e) crosslinking said multi-ply bundle.
Claim 19
Dependent Claim
16 words
The method of claim 16, further comprising the step of: (f) sterilizing said crosslinked multi-ply bundle.
Claim 20
Dependent Claim
26 words
The method of claim 17, further comprising the step of: (g) coating said multi-ply bundle with pharmaceuticals, growth factors, hormones, extracellular matrix components, or genetic material.
Claim 21
Dependent Claim
17 words
The method of claim 16, wherein the crosslinking is accomplished by crosslinking agent 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC).
Claim 22
Dependent Claim
15 words
The method of claim 11, wherein the multi-ply bundle is between 2 and 1000 ply.
Claim 23
Dependent Claim
15 words
The method of claim 11, wherein the multi-ply bundle is between 20 and 500 ply.
Claim 24
Independent Claim
119 words
A method for increasing the strength of a multi-ply bundle of collagen threads, comprising: (a) plasticizing a multi-ply bundle of collagen threads of between 2 and 1000-ply with a plasticizing agent selected from the group consisting of water, an aqueous buffered solution, or glycerol; (b) imparting a tensile load to said multi-ply bundle by elongating the said bundle to impart a strain on said multi-ply bundle of about 5% to about 10%; (c) allowing the load in said multi-ply bundle to decrease by stress-relaxation or by creep to less than 0.5 grams; (d) repeating said elongation in repeated increments; (e) removing the plasticizing agent from said multi-ply bundle; (f) crosslinking said multi-ply bundle; and, (g) sterilizing said crosslinked bundle.
Claim 25
Independent Claim
119 words
A method for increasing the strength of a multi-ply bundle of collagen threads, comprising: (a) plasticizing a multi-ply bundle of collagen threads of between 2 and 1000-ply with a plasticizing agent selected from the group consisting of water, an aqueous buffered solution, or glycerol; (b) imparting a tensile load to said multi-ply bundle by elongating the said bundle to impart a strain on said multi-ply bundle of about 5% to about 10%; (c) allowing the load in said multi-ply bundle to decrease by stress-relaxation or by creep to less than 0.5 grams; (d) repeating said elongation in repeated increments; (e) removing the plasticizing agent from said multi-ply bundle; (f) crosslinking said multi-ply bundle; and, (g) sterilizing said crosslinked bundle.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-02-16 | 2001-08-18 | 2002-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-02-16 | 2005-08-18 | 2006-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-02-16 | 2009-08-18 | 2010-02-17 | $7700.00 | Window Closed / Lapsed |