US5711969A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Large area submucosal tissue graft constructs
Assignee: Methodist Hospital
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Filing: 1995-04-07
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Granted: 1998-01-27
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Expires: 2015-04-07
Abstract
Abstract A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.
Inventors
- 👤 Umesh H. Patel
- 👤 Michael C. Hiles
- 👤 Bryan Whitson
- 👤 Boyle Cheng
- 👤 Stephen F. Badylak
- 👤 Klod Kokini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:57
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61F; A61F2/00; A61F2/0063; A61K; A61K35/00; A61K35/12; A61K35/37; A61K35/38; A61L27/3604; A61L27/3629; A61P; A61P43/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
66 words
A unitary heterolaminar tissue graft construct consisting essentially of multiple strips of intestinal submucosa tissue fused to one another by compressing the strips under dehydrating conditions, said heterolaminar construct having a variable number of layers of intestinal submucosa tissue superimposed at different points on the construct and the construct has a surface area greater than any one of the individual strips used to form said construct.
Claim 2
Dependent Claim
66 words
A unitary heterolaminar tissue graft construct consisting essentially of multiple strips of intestinal submucosa tissue fused to one another by compressing the strips under dehydrating conditions, said heterolaminar construct having a variable number of layers of intestinal submucosa tissue superimposed at different points on the construct and the construct has a surface area greater than any one of the individual strips used to form said construct.
Claim 3
Dependent Claim
75 words
A unitary tissue graft construct consisting essentially of multiple strips of intestinal submucosa tissue fused to one another by compressing the strips under dehydrating conditions, said graft construct formed to have a three dimensional shape and a variable number of layers of submucosal tissue superimposed at different points on the graft construct, and wherein said graft construct has a surface area greater than any one of the individual strips used to form said graft construct.
Claim 4
Dependent Claim
75 words
A unitary tissue graft construct consisting essentially of multiple strips of intestinal submucosa tissue fused to one another by compressing the strips under dehydrating conditions, said graft construct formed to have a three dimensional shape and a variable number of layers of submucosal tissue superimposed at different points on the graft construct, and wherein said graft construct has a surface area greater than any one of the individual strips used to form said graft construct.
Claim 5
Dependent Claim
29 words
The graft construct of claim 1, wherein the intestinal submucosa tissue comprises the tunica submucosa delaminated from both the tunica muscularis and the luminal portion of the tunica mucosa.
Claim 6
Dependent Claim
21 words
The graft construct of claim 1, wherein the submucosa strips are conditioned to have a strain of no more than 20%.
Claim 7
Dependent Claim
65 words
A unitary heterolaminar tissue graft construct consisting essentially of multiple strips of intestinal submucosa tissue fused to one another by compressing the strips under dehydrating conditions, said heterolaminar construct having only a single layer of intestinal submucosa tissue at different points on the construct, and wherein the construct has a surface area greater than any one of the individual strips used to form said construct.
Claim 8
Dependent Claim
65 words
A unitary heterolaminar tissue graft construct consisting essentially of multiple strips of intestinal submucosa tissue fused to one another by compressing the strips under dehydrating conditions, said heterolaminar construct having only a single layer of intestinal submucosa tissue at different points on the construct, and wherein the construct has a surface area greater than any one of the individual strips used to form said construct.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-26 | 2001-07-28 | 2002-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-26 | 2005-07-28 | 2006-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-26 | 2009-07-28 | 2010-01-27 | $7700.00 | Window Closed / Lapsed |