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US5650108A
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Porous bone replacement materials
Assignee: Merck Patent GmbH
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Filing: 1995-10-05
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Granted: 1997-07-22
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Expires: 2015-10-05
Abstract
Abstract A process for the preparation of porous bone replacement materials which have a partly or completely interconnecting pore system with a volume content of 5 to 60%. The bone replacement material is prepared from a mixture of a solid component, a liquid component based on acrylate/methacrylate and coarse-particled granules of a biocompatible material with an average particle diameter of 0.5 to 10 mm.
Inventors
- 👤 Berthold Nies
- 👤 Sabine Troster
- 👤 Rainer Specht
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:47
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/56; A61L24/00; A61L24/001; A61L24/0036; A61L24/0047; A61L24/0073; A61L24/0084; A61L24/0094; A61L24/04; A61L24/06; A61L27/40; A61L27/44; A61L27/46; A61L27/48; A61L27/505; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
122 words
A process for the preparation of porous bone replacement materials which have a partly or completely interconnecting pore system with a volume content of 5 to 60%, which comprises mixing the following components (a), (b) and (c) with one another: (a) 0 to 48% by weight of a solid component comprising a finely divided polymer of an acrylic or methacrylic acid ester or mixture thereof, (b) 2 to 50% by weight of a liquid component comprising an acrylic or methacrylic acid ester monomer or mixture thereof, and (c) 50 to 98% by weight of coarse-particled granules of a biocompatible material having a largest particle diameter of 0.5 to 10 mm, optionally forming the mixture into a desired shape and hardening the mixture.
Claim 2
Dependent Claim
122 words
A process for the preparation of porous bone replacement materials which have a partly or completely interconnecting pore system with a volume content of 5 to 60%, which comprises mixing the following components (a), (b) and (c) with one another: (a) 0 to 48% by weight of a solid component comprising a finely divided polymer of an acrylic or methacrylic acid ester or mixture thereof, (b) 2 to 50% by weight of a liquid component comprising an acrylic or methacrylic acid ester monomer or mixture thereof, and (c) 50 to 98% by weight of coarse-particled granules of a biocompatible material having a largest particle diameter of 0.5 to 10 mm, optionally forming the mixture into a desired shape and hardening the mixture.
Claim 3
Dependent Claim
25 words
The process of claim 1, wherein the solid component (a) further comprises at least one of a polymerization catalyst, X-ray contrast medium, filler or dyestuff.
Claim 4
Dependent Claim
17 words
The process of claim 1, wherein the liquid component (b) further comprises a polymerization accelerator or stabilizer.
Claim 5
Dependent Claim
20 words
The process according to claim 1, wherein the coarse-particled granules (c) have an average particle diameter of from 1-5 mm.
Claim 6
Dependent Claim
19 words
The process of claim 1, wherein the coarse-particled granules (c) have an average particle diameter of about 3 mm.
Claim 7
Dependent Claim
21 words
The process according to claim 1, wherein the coarse-particled granules (c) have a spherical shape, approximately spherical shape or cylindrical shape.
Claim 8
Dependent Claim
63 words
The process according to claim 1, wherein the coarse-particled granules (c) are a hardened mixture of about 5 to 90% by weight of a solid component comprising a finely divided polymer of an acrylic or methacrylic acid ester or mixture thereof, and about 95 to 10% by weight of a liquid component comprising an acrylic and/or methacrylic acid ester monomer or mixture thereof.
Claim 9
Dependent Claim
30 words
The process of claim 7, wherein the solid component used to prepare the coarse-particled granules further comprises at least one of a polymerization catalyst, X-ray contrast medium filler or dye.
Claim 10
Dependent Claim
26 words
The process of claim 7, wherein the liquid component used to prepare the coarse-particled granules further comprises at least one of a polymerization accelerator or stabilizer.
Claim 11
Dependent Claim
29 words
The process according to claim 1, wherein the coarse-particled granules (c) comprise a hardened plastics material based on polyolefins, copolymers of acrylates with styrene and/or butadiene or epoxy resins.
Claim 12
Dependent Claim
17 words
The process according to claim 1, wherein the coarse-particled granules (c) are a sintered calcium phosphate ceramic.
Claim 13
Dependent Claim
23 words
The process according to claim 1, wherein the solid component (a) and/or the coarse-particled granules (c) further comprise an osteoinductive or osteoconductive filler.
Claim 14
Dependent Claim
22 words
The process according to claim 1, wherein the solid component (a) and/or the coarse-particled granules (c) further comprise a pharmaceutically active compound.
Claim 15
Dependent Claim
26 words
The process of claim 7, wherein the liquid component used to prepare the coarse-particled granules further comprises at least one of a polymerization accelerator or stabilizer.
Claim 16
Dependent Claim
27 words
The process of claim 1, wherein a solid component (a) having an average particle size of 5 to 250 μm is mixed with components (b) and (c).
References Cited (Backward Citations)
EP0016906A1
Cited
WO1985000291A1
Cited
US5425770A
Cited
EP0519293A2
Cited
US5356629A
Cited
US5370692A
Cited
US5538514A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2000-07-21 | 2001-01-20 | 2001-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-21 | 2005-01-20 | 2005-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-07-21 | 2009-01-20 | 2009-07-22 | $7700.00 | Window Closed / Lapsed |