Patent US5577509A successfully refreshed from Google Patents.
US5577509A
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Systems and methods for examining the electrical characteristics and timing of electrical events in cardiac tissue
Assignee: EP Technologies Inc
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Filing: 1994-01-28
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Granted: 1996-11-26
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Expires: 2014-01-28
Abstract
Abstract Systems and methods examine heart tissue morphology using a pair of electrodes, at least one of which is located in contact with heart tissue. The systems and methods transmit electrical current in a path through the contacted heart tissue between the pair of the electrodes to derive a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path. The system and methods also sense with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
Inventors
- 👤 Dorin N. Panescu
- 👤 David K. Swanson
- 👤 Mark S. Mirotznik
- 👤 David S. Schwartzman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:57
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/68; A61B5/6846; A61B5/6847; A61B5/6852; A61B5/6855; A61B18/00; A61B18/04; A61B18/12; A61B18/14; A61B18/1492; A61B5/05; A61B5/053; A61B5/0538; A61B5/24; A61B5/25; A61B5/279; A61B5/28; A61B5/283; A61B5/287; A61B5/316; A61B5/318; A61B5/346; A61B5/349; A61B5/6858; A61B17/00; A61B17/00234; A61B2017/00292; A61B2017/003; A61B2018/00053; A61B2018/00214; A61B2018/00636; A61B2018/00696; A61B2018/00755; A61B2018/00761; A61B2018/00773; A61B2018/00875; A61B2018/00886; A61B18/1206; A61B2018/124; A61B2018/1246; A61B2018/1253; A61B2018/126; A61B2018/1273; A61B2018/128; A61B2562/00; A61B2562/04; A61B2562/043
Claims Analysis
Total Claims: 64
Claim 1
Independent Claim
89 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 2
Independent Claim
89 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 3
Dependent Claim
25 words
A system according to claim 1 wherein the locating means is adapted to located at least one of the electrodes in contact with endocardial tissue.
Claim 4
Dependent Claim
36 words
A system according to claim 2 wherein the locating means is adapted to locate one of the electrodes in contact with endocardial tissue and to locate the other electrode in contact with tissue outside the heart.
Claim 5
Dependent Claim
18 words
A system according to claim 1 wherein the locating means locates both electrodes in contact with endocardial tissue.
Claim 6
Dependent Claim
26 words
A system according to claim 1 wherein the locating means includes a catheter tube having a distal end that carries at least one of the electrodes.
Claim 7
Dependent Claim
26 words
A system according to claim 5 wherein the catheter tube carries a multiplexer/demultiplexer block electrically coupled to at least two electrodes that the catheter tube carries.
Claim 8
Independent Claim
87 words
A system for examining tissue within the heart comprising a pair of electrodes, means for locating the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the resistivity of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 9
Independent Claim
87 words
A system for examining tissue within the heart comprising a pair of electrodes, means for locating the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the resistivity of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 10
Dependent Claim
21 words
A system according to claim 7 wherein the locating means is adapted to locate the electrodes in contact with endocardial tissue.
Claim 11
Dependent Claim
26 words
A system according to claim 7 wherein the locating means includes a catheter tube having a distal end that carries at least one of the electrodes.
Claim 12
Dependent Claim
26 words
A system according to claim 9 wherein the catheter tube carries a multiplexer/demultiplexer block electrically coupled to at least one electrode that the catheter tube carries.
Claim 13
Independent Claim
99 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path and generating a first output, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue and generating a second output.
Claim 14
Independent Claim
99 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path and generating a first output, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue and generating a second output.
Claim 15
Dependent Claim
20 words
A system according to claim 11 wherein the first output includes the electrical characteristic in spatial relation to the path.
Claim 16
Dependent Claim
13 words
A system according to claim 11 wherein the second output comprises an electrogram.
Claim 17
Dependent Claim
25 words
A system according to claim 11 wherein the locating means is adapted to locate at least one of the electrodes in contact with endocardial tissue.
Claim 18
Dependent Claim
36 words
A system according to claim 14 wherein the locating means is adapted to locate one of the electrodes in contact with endocardial tissue and to locate the other electrode in contact with tissue outside the heart.
Claim 19
Dependent Claim
21 words
A system according to claim 11 wherein the locating means is adapted to locate both electrodes in contact with endocardial tissue.
Claim 20
Dependent Claim
26 words
A system according to claim 11 wherein the locating means includes a catheter tube having a distal end that carries at least one of the electrodes.
Claim 21
Dependent Claim
26 words
A system according to claim 17 wherein the catheter tube carries a multiplexer/demultiplexer block electrically coupled to at least two electrodes that the catheter tube carries.
Claim 22
Independent Claim
152 words
A system for examining heart tissue comprising at least three spaced apart electrodes, means for locating at least two of the electrodes within the heart for contact with endocardial tissue, generator means operable in one mode for transmitting electrical current in a first path through a region of heart tissue between a first pair of the electrodes, at least one of which is within the heart, the generator means being operable in another mode for transmitting electrical current in a second path through heart tissue in the region between a second pair of the electrodes, at least one of which is within the heart, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedances of the tissue lying in the first and second paths, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 23
Independent Claim
152 words
A system for examining heart tissue comprising at least three spaced apart electrodes, means for locating at least two of the electrodes within the heart for contact with endocardial tissue, generator means operable in one mode for transmitting electrical current in a first path through a region of heart tissue between a first pair of the electrodes, at least one of which is within the heart, the generator means being operable in another mode for transmitting electrical current in a second path through heart tissue in the region between a second pair of the electrodes, at least one of which is within the heart, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedances of the tissue lying in the first and second paths, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 24
Independent Claim
176 words
A system for examining heart tissue comprising at least three spaced apart electrodes adapted to be in contact with the heart, means for locating at least two of the electrodes within the heart for contact with endocardial tissue, generator means operable in one mode for transmitting electrical current in a first path through a region of heart tissue between a first pair of the electrodes, at least one of which is within the heart, the generator means being operable in another mode for transmitting electrical current in a second path through heart tissue in the region between a second pair of the electrodes, at least one of which is within the heart, without substantially altering the position of the first pair of electrodes relative to the heart tissue, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedances of the tissue lying in the first and second paths, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 25
Independent Claim
176 words
A system for examining heart tissue comprising at least three spaced apart electrodes adapted to be in contact with the heart, means for locating at least two of the electrodes within the heart for contact with endocardial tissue, generator means operable in one mode for transmitting electrical current in a first path through a region of heart tissue between a first pair of the electrodes, at least one of which is within the heart, the generator means being operable in another mode for transmitting electrical current in a second path through heart tissue in the region between a second pair of the electrodes, at least one of which is within the heart, without substantially altering the position of the first pair of electrodes relative to the heart tissue, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedances of the tissue lying in the first and second paths, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue.
Claim 26
Dependent Claim
24 words
A system according to claim 20 and further including first output generating means for generating a first output based upon the derived electrical characteristic.
Claim 27
Dependent Claim
27 words
A system according to claim 21 wherein the first output includes the derived electrical characteristic in spatial relation to the location of the first and second paths.
Claim 28
Dependent Claim
29 words
A system according to claim 20 and 21 and further including second output generating means for generating a second output based upon the sensed timing of local depolaziation events.
Claim 29
Dependent Claim
27 words
A system according to claim 23 and wherein the second output generating means includes means for arranging the sensed local depolarization events into groups of equal timing.
Claim 30
Dependent Claim
39 words
A system according to claim 23 and wherein the second output generating means includes means for generating a third output of the groups of equal timing in spatial relation to the location of the multiple paths in the region.
Claim 31
Dependent Claim
14 words
A system according to claim 25 wherein the third output comprises an iso-chronal output.
Claim 32
Dependent Claim
14 words
A system according to claim 25 wherein the third output comprises an iso-delay output.
Claim 33
Dependent Claim
20 words
A system according to claim 23 and further including means for generating an output based upon the derived electrical characteristic.
Claim 34
Dependent Claim
26 words
A system according to claim 28 wherein the output includes the derived electrical characteristic in spatial relation to the location of the first and second paths.
Claim 35
Independent Claim
90 words
A method for examining heart tissue comprising the steps of locating at least a first electrode in contact with heart tissue, locating a second electrode so that a region of heart tissue lies between it and the first electrode, transmitting electrical current between the first and second electrodes through the region of heart tissue, deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue in the region, and also sensing with the first electrode the timing of local depolarization events in the region.
Claim 36
Independent Claim
90 words
A method for examining heart tissue comprising the steps of locating at least a first electrode in contact with heart tissue, locating a second electrode so that a region of heart tissue lies between it and the first electrode, transmitting electrical current between the first and second electrodes through the region of heart tissue, deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue in the region, and also sensing with the first electrode the timing of local depolarization events in the region.
Claim 37
Dependent Claim
25 words
A method according to claim 30 wherein, in the step of locating the first electrode, the first electrode is placed into contact with endocardial tissue.
Claim 38
Dependent Claim
27 words
A method according to claim 31 wherein, in the step of locating the second electrode, the second electrode is placed into contact with tissue outside the heart.
Claim 39
Dependent Claim
26 words
A method according to claim 30 wherein, in the steps of locating the first and second electrodes, both electrodes are placed into contact with endocardial tissue.
Claim 40
Dependent Claim
25 words
A method according to claim 30 wherein, in the step of deriving the tissue electrical characteristic, the resistivity of tissue in the region is derived.
Claim 41
Dependent Claim
23 words
A method according to claim 30 and further including the step of creating an output based upon of the derived tissue electrical characteristic.
Claim 42
Dependent Claim
25 words
A method according to claim 30 and further including the step of creating an output of the timing of local depolarization events in the region.
Claim 43
Dependent Claim
25 words
A method according to claim 36 and wherein the step of creating the output arranges the sensed local depolarization events into groups of equal timing.
Claim 44
Dependent Claim
29 words
A method according to claim 37 and wherein the step of creating the output includes the groups of equal timing in spatial relation to the location of the region.
Claim 45
Dependent Claim
21 words
A method according to claim 36 and further including the step of creating an output based upon the derived electrical characteristic.
Claim 46
Independent Claim
128 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue, the locating means including a catheter tube having a distal end that carries at least one of the electrodes, and the catheter tube carrying a multiplexer/demultiplexer block electrically coupled to at least two electrodes that the catheter tube carries.
Claim 47
Independent Claim
128 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue, the locating means including a catheter tube having a distal end that carries at least one of the electrodes, and the catheter tube carrying a multiplexer/demultiplexer block electrically coupled to at least two electrodes that the catheter tube carries.
Claim 48
Independent Claim
126 words
A system for examining tissue within the heart comprising a pair of electrodes, means for locating the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the resistivity of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue, the locating means including a catheter tube having a distal end that carries at least one of the electrodes, and the catheter tube carrying a multiplexer/demultiplexer block electrically coupled to at least one electrode that the catheter tube carries.
Claim 49
Independent Claim
126 words
A system for examining tissue within the heart comprising a pair of electrodes, means for locating the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the resistivity of the tissue lying in the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue, the locating means including a catheter tube having a distal end that carries at least one of the electrodes, and the catheter tube carrying a multiplexer/demultiplexer block electrically coupled to at least one electrode that the catheter tube carries.
Claim 50
Independent Claim
109 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path and generating a first output including the electrical characteristic in spatial relation to the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue and generating a second output.
Claim 51
Independent Claim
109 words
A system for examining heart tissue comprising a pair of electrodes, means for locating at least one of the electrodes in contact with heart tissue, means for transmitting electrical current in a path through the contacted heart tissue between the pair of the electrodes, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path and generating a first output including the electrical characteristic in spatial relation to the path, and means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue and generating a second output.
Claim 52
Dependent Claim
47 words
A system according to claim 42 wherein the locating means includes a catheter tube having a distal end that carries at least one of the electrodes, and wherein the catheter tube carries a multiplexer/demultiplexer block electrically coupled to at least two electrodes that the catheter tube carries.
Claim 53
Independent Claim
206 words
A system for examining heart tissue comprising at least three spaced apart electrodes adapted to be in contact with the heart, means for locating at least two of the electrodes within the heart for contact with endocardial tissue, generator means operable in one mode for transmitting electrical current in a first path through a region of heart tissue between a first pair of the electrodes, at least one of which is within the heart, the generator means being operable in another mode for transmitting electrical current in a second path through heart tissue in the region between a second pair of the electrodes, at least one of which is within the heart, without substantially altering the position of the first pair of electrodes relative to the heart tissue, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedances of the tissue lying in the first and second paths, means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue and means for generating a first output based upon the derived electrical characteristic and including the derived electrical characteristic in spatial relation to the location of the first and second paths.
Claim 54
Independent Claim
206 words
A system for examining heart tissue comprising at least three spaced apart electrodes adapted to be in contact with the heart, means for locating at least two of the electrodes within the heart for contact with endocardial tissue, generator means operable in one mode for transmitting electrical current in a first path through a region of heart tissue between a first pair of the electrodes, at least one of which is within the heart, the generator means being operable in another mode for transmitting electrical current in a second path through heart tissue in the region between a second pair of the electrodes, at least one of which is within the heart, without substantially altering the position of the first pair of electrodes relative to the heart tissue, means for deriving a tissue electrical characteristic based, at least in part, upon sensing the impedances of the tissue lying in the first and second paths, means for sensing with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue and means for generating a first output based upon the derived electrical characteristic and including the derived electrical characteristic in spatial relation to the location of the first and second paths.
Claim 55
Dependent Claim
23 words
A system according to claim 44 further including means for generating a second output based upon the sensed timing of local depolarization events.
Claim 56
Dependent Claim
26 words
A system according to claim 45 wherein the second output generating means includes means for arranging the sensed local depolarization events into groups of equal timing.
Claim 57
Dependent Claim
38 words
A system according to claim 45 wherein the second output generating means includes means for generating a third output of the groups of equal timing in spatial relation to the location of the multiple paths in the region.
Claim 58
Dependent Claim
14 words
A system according to claim 45 wherein the third output comprises an iso-chronal output.
Claim 59
Dependent Claim
14 words
A system according to claim 45 wherein the third output comprises an iso-delay output.
Claim 60
Independent Claim
131 words
A method for examining heart tissue comprising the steps of locating at least a first electrode in contact with heart tissue, locating a second electrode so that a region of heart tissue lies between it and the first electrode, transmitting electrical current between the first and second electrodes through the region of heart tissue, deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue in the region, and also sensing with the first electrode the timing of local depolarization events in the region, wherein, in the step of locating the first electrode, the first electrode is placed into contact with endocardial tissue, and wherein, in the step of locating the second electrode, the second electrode is placed into contact with tissue outside the heart.
Claim 61
Independent Claim
131 words
A method for examining heart tissue comprising the steps of locating at least a first electrode in contact with heart tissue, locating a second electrode so that a region of heart tissue lies between it and the first electrode, transmitting electrical current between the first and second electrodes through the region of heart tissue, deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue in the region, and also sensing with the first electrode the timing of local depolarization events in the region, wherein, in the step of locating the first electrode, the first electrode is placed into contact with endocardial tissue, and wherein, in the step of locating the second electrode, the second electrode is placed into contact with tissue outside the heart.
Claim 62
Independent Claim
120 words
A method for examining heart tissue comprising the steps of locating at least a first electrode in contact with heart tissue, locating a second electrode so that a region of heart tissue lies between it and the first electrode, transmitting electrical current between the first and second electrodes through the region of heart tissue, deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue in the region, sensing with the first electrode the timing of local depolarization events in the region, and creating an output of the timing of local depolarization events in the region, wherein the step of creating the output arranges the sensed local depolarization events into groups of equal timing.
Claim 63
Independent Claim
120 words
A method for examining heart tissue comprising the steps of locating at least a first electrode in contact with heart tissue, locating a second electrode so that a region of heart tissue lies between it and the first electrode, transmitting electrical current between the first and second electrodes through the region of heart tissue, deriving a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue in the region, sensing with the first electrode the timing of local depolarization events in the region, and creating an output of the timing of local depolarization events in the region, wherein the step of creating the output arranges the sensed local depolarization events into groups of equal timing.
Claim 64
Dependent Claim
28 words
A method according to claim 51 wherein the step of creating the output includes the groups of equal timing in spatial relation to the location of the region.
References Cited (Backward Citations)
US4380237A
Cited
US4522212A
Cited
US4682596A
Cited
US4628937A
Cited
US4674518A
Cited
US4699147A
Cited
US4852580A
Cited
US5397339A
Cited
US4836214A
Cited
US5109870A
Cited
US5041973A
Cited
US4911174A
Cited
US5195968A
Cited
US5137019A
Cited
US5233515A
Cited
US5058583A
Cited
US5092339A
Cited
US5246008A
Cited
US5228442A
Cited
US5279299A
Cited
US5406946A
Cited
US5156151A
Cited
US5345936A
Cited
US5383917A
Cited
US5224475A
Cited
US5282840A
Cited
US5239999A
Cited
US5255679A
Cited
US5324284A
Cited
US5197467A
Cited
US5341807A
Cited
US5297549A
Cited
US5313943A
Cited
US5309910A
Cited
US5293869A
Cited
US5334193A
Cited
US5409000A
Cited
US5447529A
Cited
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