Multiple frequency impedance measurement system

Claim 2

A cardiac pacemaker, comprising: pulse generator means for generating cardiac pacing pulses and for delivering said cardiac pacing pulses to a patient's heart; timing means coupled to said pulse generator means for controlling the rate at which said pacing pulses are generated; means for monitoring said patient's body tissue, said means for monitoring comprising a pair of electrodes adapted to be in contact with said tissue to be monitored, signal generator means for generating electrical signals at at least first and second frequencies for application to said pair of electrodes, measuring means responsive to signals at said first and second frequencies, for measuring the impedance between said pair of electrodes at said first and second frequencies, and means for detecting changes in the relationship of said measured impedances at said first and second frequencies; and means coupled to said monitoring means and to said timing means for varying the rate at which said pacing pulses are generated in response to the detection of changes in said relationship of said impedances measured at said first and second frequencies.

Claim 3

A pacemaker according to claim 1 wherein aid first and second frequencies are separated by a factor of ten or greater.

Claim 4

A pacemaker according to claim 1 wherein said pacemaker further comprises means for activation of said monitoring means at predetermined times following generation of said pacing paces.

Claim 5

A pacemaker according to claim 1 wherein said signal generator means comprises first and second signal sources each functioning to generate one of said first and second frequencies.

Claim 6

A pacemaker according to claim 1 wherein said signal generator means comprises a pink noise generator, for generating electrical signals across a band of frequencies including said first and second frequencies.

Claim 7

A pacemaker according to claim 1 or claim 4 or claim 5 wherein said pacemaker further comprises first and second tuned band-pass filter means for selectively allowing passage of signals at said first and second frequencies and wherein said measuring means comprises mean responsive to said first and second band-pass filter means.

Claim 8

A pacemaker according to claim 1 wherein said monitoring means comprises means for calculating average values of said impedances measured at said first and second frequencies over predetermined periods of time and wherein said detecting means comprises mean for comparing said average values to detect changes in said relationship of said measured impedances at said first and second frequencies.

Claim 9

A pacemaker according to claim 1 wherein said monitoring means comprises means for measuring variations in said impedances at said first and second frequencies associated with functioning of said body tissue wherein said detecting means comprises means for detecting changes in said variations over time.

Claim 10

A pacemaker according to claim 1 wherein said pair of electrodes are adapted for location such that a substantial amount of said patient's lung tissue is between said electrodes and wherein said monitoring means comprises means for measuring the modulation of said relationship of said impedances measured at said first and second frequencies and wherein said varying means comprises means for varying the rate of generation of said pacing pulses as a function of the rate of said measured modulation.

Claim 11

A pacemaker according to claim 1 wherein said pair of electrodes are adapted for location such that at least one of said pair of electrodes is adapted for location adjacent heart tissue and wherein said monitoring means comprises means for measuring changes in said relationship of said impedances measured at said first and second frequencies and wherein said varying means comprises means for varying the rate of generation of said pacing pulses in response to said measured changes.

Claim 12

A pacemaker according to claim 1 wherein said pair of electrodes are adapted for location such that at least one of said pair of electrodes is adapted for location adjacent heart tissue and wherein aid pulse generator means is coupled to aid at least one of said pair of electrodes.

Claim 13

A physiological monitoring device, comprising: means for monitoring the condition of a patient's body tissue, said means for monitoring comprising a pair of electrodes adapted to be in contact with said tissue to be monitored, signal generator means for generating electrical signals at at least first and second frequencies for application to said pair of electrodes, measuring means responsive to signals at said first and second frequencies, for measuring the impedance between said pair of electrodes at said first and second frequencies, and means for detecting changes in the relationship of said measured impedances at said first and second frequencies, wherein said monitoring means comprises mean for calculating average values of said impedances measured at said first and second frequencies over predetermined periods of time and wherein said detecting means comprises means for comparing said average values to detect changes in said relationship of said measured impedances at said first and second frequencies; and means coupled to said monitoring means for providing indications of said detected changes in said relationship of said impedances measured at said first and second frequencies.

Claim 14

A physiological monitoring device, comprising: means for monitoring the condition of a patient's body tissue, said means for monitoring comprising a pair of electrodes adapted to be in contact with said tissue to be monitored, signal generator means for generating electrical signals at at least first and second frequencies for application to said pair of electrodes, measuring means responsive to signals at said first and second frequencies, for measuring the impedance between said pair of electrodes at said first and second frequencies, and means for detecting changes in the relationship of said measured impedances at said first and second frequencies, wherein said monitoring means comprises mean for calculating average values of said impedances measured at said first and second frequencies over predetermined periods of time and wherein said detecting means comprises means for comparing said average values to detect changes in said relationship of said measured impedances at said first and second frequencies; and means coupled to said monitoring means for providing indications of said detected changes in said relationship of said impedances measured at said first and second frequencies.

Claim 15

A device according to claim 12 wherein said first and second frequencies are separated by a factor of ten or greater.

Claim 16

A device according to claim 12 wherein said signal generator means comprises first and second signal sources each functioning to generate one of said first and second frequencies.

Claim 17

A device according to claim 12 wherein said signal generator means comprises means for generating electrical signals across a band of frequencies including said first and second frequencies.

Claim 18

A device according to claim 12 or claim 14 or claim 15 wherein said device further comprises first and second tuned band-pass filter means for selectively allowing passage of signals at said first and second frequencies and wherein said measuring means comprises means responsive to said first and second band-pass filter means.

Claim 19

A device according to claim 12 wherein said pair of electrodes are adapted for location such that a substantial amount of said patient's lung tissue is between said electrodes and wherein said monitoring means comprises means for measuring the modulation of said relationship of said impedances measured at said first and second frequencies.

Claim 20

A device according to claim 12 wherein said pair of electrodes are adapted for location such that at least one of said pair of electrodes is adapted for location adjacent heart tissue.

Claim 23

A method according to claim 19 wherein said change measuring step comprises calculating average values of said impedances measured at said first and second frequencies over predetermined periods of time comparing said average values to detect changes in said relationship of said measured impedances at said first and second frequencies.

Claim 24

A method according to claim 19 wherein said step of applying electrical signals comprises applying electrical signals across a band of frequencies including said first and second frequencies.

Claim 25

A method according to claim 19 wherein said locating step comprises locating said pair of electrodes such hat a substantial amount of said patient's lung tissue is between said pair of electrodes.

Claim 26

A method according to claim 19 wherein said locating step comprises locating at least one of said pair of electrodes adjacent heart tissue.