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US5571166A
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Method of making an intraluminal stent
Assignee: Medtronic Inc
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Filing: 1994-09-15
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Granted: 1996-11-05
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Expires: 2014-09-15
Abstract
Abstract An intraluminal stent comprising fibrin and heparin is capable of providing a treatment of restenosis.
Inventors
- 👤 Thomas Q. Dinh
- 👤 Michael Dror
- 👤 Robert S. Schwartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:27
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/041; A61F; A61F2/00; A61F2/82; A61L31/043; A61L31/046; A61L31/047; A61L31/08; A61L31/10; A61L31/12; A61L31/125; A61L31/128; A61L31/14; A61L31/16; A61F2/0077; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/416; A61L2300/42; A61L2300/45; A61L2300/60; A61L2300/62; A61L2300/622; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
59 words
A method for making an intraluminal stent for implantation in a body lumen comprising the steps of: (a) providing a stent body; (b) applying to the stent body a composition of fibrinogen and thrombin to effect polymerization of the fibrinogen to fibrin; and (c) applying heparin to the fibrinogen and thrombin as the fibrinogen is being polymerized to fibrin.
Claim 2
Independent Claim
59 words
A method for making an intraluminal stent for implantation in a body lumen comprising the steps of: (a) providing a stent body; (b) applying to the stent body a composition of fibrinogen and thrombin to effect polymerization of the fibrinogen to fibrin; and (c) applying heparin to the fibrinogen and thrombin as the fibrinogen is being polymerized to fibrin.
Claim 3
Independent Claim
69 words
A method for making an intraluminal stent for implantation in a body lumen comprising the steps of: (a) providing a stent body; (b) applying to the stent body a composition of fibrinogen and thrombin to effect polymerization of the fibrinogen to fibrin; (c) applying heparin to the fibrinogen and thrombin as the fibrinogen is being polymerized to fibrin; and (d) applying a second layer of fibrin over the heparin.
Claim 4
Independent Claim
69 words
A method for making an intraluminal stent for implantation in a body lumen comprising the steps of: (a) providing a stent body; (b) applying to the stent body a composition of fibrinogen and thrombin to effect polymerization of the fibrinogen to fibrin; (c) applying heparin to the fibrinogen and thrombin as the fibrinogen is being polymerized to fibrin; and (d) applying a second layer of fibrin over the heparin.
Claim 5
Dependent Claim
24 words
The method of claim 2 also comprising the step of immersing the fibrin stent with second layer of fibrin in a concentrated heparin solution.
Claim 6
Dependent Claim
24 words
The method of claim 3 wherein the immersion step takes place within two hours of the commencement of polymerization of the second fibrin layer.
Claim 7
Dependent Claim
24 words
The method of claim 3 wherein the immersion step takes place within thirty minutes of the commencement of polymerization of the second fibrin layer.
Claim 8
Dependent Claim
12 words
The method of claim 1 wherein the heparin is in particulate form.
Claim 9
Dependent Claim
17 words
The method of claim 1 wherein the heparin is in the form of particles also comprising fibrin.
Claim 10
Dependent Claim
12 words
The method of claim 7 wherein the particles are in flake form.
Claim 11
Dependent Claim
39 words
The method of claim 1 wherein the composition of fibrinogen and thrombin applied to the stent body includes heparin at a concentration of heparin to fibrin in the range of about 10-200 units of heparin per milligram of fibrin.
Claim 12
Independent Claim
66 words
A method for making an intraluminal stent for implantation in a body lumen comprising the steps of: (a) providing a stent body; (b) applying to the stent body a composition of fibrinogen and thrombin to effect polymerization of fibrin on the stent body; (c) immersing the stent body with fibrin in a solution of heparin within two hours after the commencement of polymerization of the fibrin.
Claim 13
Independent Claim
66 words
A method for making an intraluminal stent for implantation in a body lumen comprising the steps of: (a) providing a stent body; (b) applying to the stent body a composition of fibrinogen and thrombin to effect polymerization of fibrin on the stent body; (c) immersing the stent body with fibrin in a solution of heparin within two hours after the commencement of polymerization of the fibrin.
Claim 14
Dependent Claim
18 words
The method of claim 10 wherein the heparin solution has a concentration of at least about 1000 units/ml.
Claim 15
Dependent Claim
21 words
The method of claim 10 wherein the heparin solution has a concentration in the range of about 10,000 to 20,000 units.
Claim 16
Dependent Claim
19 words
The method of claim 12 wherein the stent body is immersed in the heparin solution for about 12-24 hours.
Claim 17
Dependent Claim
25 words
The method of claim 10 wherein the stent body is immersed in the heparin solution within 30 minutes of commencement of polymerization of the fibrin.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1999-11-05 | 2000-05-06 | 2000-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-11-05 | 2004-05-06 | 2004-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-11-05 | 2008-05-06 | 2008-11-05 | $7700.00 | Window Closed / Lapsed |