Patent US4127249A successfully refreshed from Google Patents.
EP0397307A2
Expired / Lapsed
EP
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Water soluble high molecular polymerized drug preparation
Assignee: Japan Science and Technology Agency
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Filing: 1990-03-20
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Granted: —
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Expires: 2010-03-20
Abstract
Abstract A water-soluble block copolymer comprising a hydrophilic segment and a hydrophobic segment which contains a pharmacologically active side-chain portion. The hydrophilic first segment of the present invention is suitably polyethylene glycol, polysaccharides, or polyacrylamide. The hydrophobic segment includes polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof.
Inventors
- 👤 Yasuhisa Sakurai
- 👤 Teruo Okano
- 👤 Kazunori Kataoka
- 👤 Noriko Yamada
- 👤 Shohei Canion Manshion Inoue
- 👤 Masayuki Yokoyama
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 15:42
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61K47/645; A61K31/00; A61K31/70; A61P; A61P35/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
19 words
A water-soluble block copolymer comprising a hydrophilic segment and a hydrophobic segment which contains a pharmacologically active side-chain portion.
Claim 2
Dependent Claim
19 words
A water-soluble block copolymer comprising a hydrophilic segment and a hydrophobic segment which contains a pharmacologically active side-chain portion.
Claim 3
Dependent Claim
26 words
A copolymer according to Claim 1, which forms micelles in an aqueous medium wherein the hydrophobic segment is the inner-core and the hydrophilic segment the outer-shell.
Claim 4
Dependent Claim
15 words
A copolymer according to Claim 2, wherein the pharmacologically active portion is an anti-cancer agent.
Claim 5
Dependent Claim
12 words
A copolymer according to Claim 3, wherein the anti-cancer agent is adriamycin.
Claim 6
Dependent Claim
60 words
A copolymer according to any one of claims 1 to 4 which is represented by the formula I: R₁ is -CH₃, -CH₂CH₃ or other alkyl group, n is an integer of from 5 to 400, m is an integer from 1 to 300, and x is an integer of from 0 to 300, wherein at least one of R is
Claim 7
Dependent Claim
25 words
A pharmaceutical composition comprising a pharmacologically acceptable carrier or diluent and as active ingredient, a copolymer as claimed in anyone of claims 1 to 5.
Claim 8
Dependent Claim
37 words
A carrier for use in bearing a pharmacologically active substance comprising a hydrophilic segment and a second segment which has a side chain capable of combining with said substance and turning hydrophilic when combined with said substance.
Claim 9
Dependent Claim
37 words
A carrier for use in bearing a pharmacologically active substance comprising a hydrophilic segment and a second segment which has a side chain capable of combining with said substance and turning hydrophilic when combined with said substance.
Claim 10
Dependent Claim
21 words
A carrier according to Claim 7, of formula II: wherein R₁, m, n and x are as defined in claim 5.
Claim 11
Dependent Claim
33 words
Use of a copolymer according to any one of claims 1 to 5 or a carrier according to Claim 8 in the manufacture of a medicament for use in the treatment of cancer.
References Cited (Backward Citations)
No citation records indexed.
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