EP0498482A2
Expired / Lapsed
EP
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X-ray contrast compositions useful in medical imaging
Assignee: Perrigo Pharma International DAC
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Filing: 1992-01-20
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Granted: —
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Expires: 2012-01-20
Abstract
Abstract An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmaceutically acceptable carrier therefor is useful in x-ray diagnostic medical imaging methods. The agents can be delivered to a specific tissue or fluid site, for example, the blood pool, liver, spleen, kidney or lymph nodes. In one embodiment involving intravenous administration, preferred compositions provide effective imaging of the blood pool for remarkably long times.
Inventors
- 👤 Gary Sterling Winthrop Inc. Liversidge
- 👤 Eugene Sterling Winthrop Inc. Cooper
- 👤 Gregory Sterling Winthrop Inc. Mcintire
- 👤 J. Michael Sterling Winthrop Inc. Shaw
- 👤 Kenneth Sterling Winthrop Inc. Cundy
- 👤 John Sterling Winthrop Inc. Bishop
- 👤 David Sterling Winthrop Inc. Czekai
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 15:45
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0476; A61K49/0485; A61K49/049; A61K49/0409; A61K49/0414; A61K49/0423; A61K49/0428; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
47 words
An x-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmaceutically acceptable carrier therefor.
Claim 2
Dependent Claim
18 words
The composition of claim 1 wherein said particles have an effective particle size of less than 300 nm.
Claim 3
Dependent Claim
18 words
The composition of claim 1 wherein said particles have an effective particle size of less than 200 nm.
Claim 4
Dependent Claim
18 words
The composition of claim 1 wherein said particles have an effective particle size of less than 100 nm.
Claim 5
Dependent Claim
18 words
The composition of any one of claims 1-4 wherein said x-ray contrast agent is an iodinated aromatic compound.
Claim 6
Dependent Claim
40 words
The composition of any one of claims 1-5 wherein said x-ray contrast agent is an ester or an amide of an iodinated aromatic acid selected from the group consisting of diatrizoic acid, metrizoic acid, iothalamic acid, trimesic acid and iodipamide.
Claim 7
Dependent Claim
18 words
The composition of any one of claims 1-6 wherein said x-ray contrast agent is ethyl-3,5-diacetamido-2,4,6-triiodobenzoate, ethyl(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)acetate or ethyl-2-(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)butyrate.
Claim 8
Dependent Claim
15 words
The composition of any one of claims 1-7 wherein said carrier is an aqueous liquid.
Claim 9
Dependent Claim
20 words
The composition of any one of claims 1-8 wherein said particles are present in an amount of 10-25% by weight.
Claim 10
Dependent Claim
29 words
The composition of any one of claims 1-9 wherein said surface modifier is a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine.
Claim 11
Dependent Claim
107 words
The composition of any one of claims 1-9 wherein said surface modifier has the formula L' is a chemical bond, -O-, -S-, -NH-, - CONH- or -SO₂NH-; R⁴ is a hydrophobic substituted or unsubstituted alkyl, substituted or unsubstituted cyclo-alkyl, or a substituted or unsubstituted aryl group; each of R⁵ and R⁶ independently is hydrogen or an alkyl group having from 1 to 4 carbon atoms; each of a and b independently is 0 or an integer from 1 to 3, provided that the sum of a and b is not greater than 3; and, each of x and y independently is an integer from 3 to 7.
Claim 12
Dependent Claim
34 words
The composition of claim 1 comprising particles consisting essentially of crystalline ethyl-3,5-diacetamido-2,4,6-triiodobenzoate having a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine adsorbed on the surface thereof.
Claim 13
Dependent Claim
41 words
The composition of claim 1 comprising particles consisting essentially of crystals of the ethyl glycolate ester of diatrizoic acid having a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine adsorbed on the surface thereof.
Claim 14
Dependent Claim
34 words
The composition of claim 1 comprising particles consisting essentially of crystalline ethyl-2-(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)butyrate having a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine adsorbed on the surface thereof.
Claim 15
Independent Claim
34 words
A method for medical x-ray diagnostic imaging which comprises administering to the body of a test subject an effective contrast producing amount of the x-ray contrast composition defined in any one of claims 1-14.
Claim 16
Independent Claim
93 words
A method for the preparation of an x-ray contrast composition which includes the steps of: introducing a non-radioactive organic x-ray contrast agent, a liquid medium, rigid grinding media having an average size of less than 3 mm, and optionally a surface modifier into a grinding vessel; wet grinding said contrast agent and thereafter mixing a surface modifier with said liquid medium if a surface modifier was not present during grinding to form particles having an average size of less than about 400 nm; and separating said particles from said grinding vessel and media.
References Cited (Backward Citations)
No citation records indexed.
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