US5563146A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating hyperproliferative vascular disease
Assignee: Wyeth LLC
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Filing: 1995-05-26
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Granted: 1996-10-08
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Expires: 2015-05-26
Abstract
Abstract This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.
Inventors
- 👤 Randall E. Morris
- 👤 Clare R. Gregory
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/70; A61K31/7042; A61K31/7052; A61K31/706; A61K31/395; A61K31/435; A61K31/4353; A61K31/436; A61K45/00; A61K45/06; A61P; A61P7/00; A61P7/02; A61P9/00; A61P9/10
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
51 words
A method of preventing restenosis in a mammal resulting from said mammal undergoing a vascular catheterization, vascular scraping, vascular surgery, or laser treatment procedure which comprises administering an antirestenosis effective amount of rapamycin to said mammal orally, parenterally intravascularly, intranasally, intrabronchially, transdermally, rectally, or via a vascular stent impregnated with rapamycin.
Claim 2
Independent Claim
51 words
A method of preventing restenosis in a mammal resulting from said mammal undergoing a vascular catheterization, vascular scraping, vascular surgery, or laser treatment procedure which comprises administering an antirestenosis effective amount of rapamycin to said mammal orally, parenterally intravascularly, intranasally, intrabronchially, transdermally, rectally, or via a vascular stent impregnated with rapamycin.
Claim 3
Dependent Claim
20 words
The method according to claim 1, wherein the administration of the rapamycin is initiated before the mammal undergoes the procedure.
Claim 4
Dependent Claim
34 words
The method according to claim 2, wherein the rapamycin is administered for 3 or more days before the mammal undergoes the procedure and said administration continues for 8 or more days following the procedure.
Claim 5
Dependent Claim
19 words
The method according to claim 3, wherein the rapamycin is administered for 13 or more days following the procedure.
References Cited (Backward Citations)
US3929992A
Cited
US4885171A
Cited
EP0401747A2
Cited
US5100899A
Cited
US5078999A
Cited
US5080899A
Cited
US5288711A
Cited
US5256790A
Cited
US5252579A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-08 | 2000-04-08 | 2000-10-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-08 | 2004-04-08 | 2004-10-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-08 | 2008-04-08 | 2008-10-08 | $7700.00 | Window Closed / Lapsed |