US5100899A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
Assignee: Individual
•
Filing: 1989-06-06
•
Granted: 1992-03-31
•
Expires: 2009-06-06
Abstract
Abstract This invention provides a method of inhibiting organ or tissue transplant rejection in a mammal in need thereof, comprising administering to said mammal a transplant rejection inhibiting amount of rapamycin. Also disclosed is a method of inhibiting organ or tissue transplant rejection in a mammal in need thereof, comprising administering to said mammal (a) an amount of rapamycin in combination with (b) an amount of one or more other chemotherapeutic agents for inhibiting transplant rejection, e.g., azathioprine, corticosteroids, cyclosporin and FK506, said amounts of (a) and (b) together being effective to inhibit transplant rejection and to maintain inhibition of transplant rejection.
Inventors
- 👤 Roy Calne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/519; A61K31/52; A61K31/435; A61K31/44; A61K31/445; A61K31/56; A61K31/57; A61K38/00; A61K38/04; A61K38/12; A61K38/13; A61P; A61P37/00; A61P37/02; A61P37/06
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
27 words
A method of inhibiting organ or tissue transplant rejection in a mammal in need thereof, comprising administrating to said mammal a transplant rejection inhibiting amount of rapamycin.
Claim 2
Independent Claim
27 words
A method of inhibiting organ or tissue transplant rejection in a mammal in need thereof, comprising administrating to said mammal a transplant rejection inhibiting amount of rapamycin.
Claim 3
Dependent Claim
27 words
The method according to claim 1, wherein a transplant rejection inhibiting amount of rapamycin is administered in an amount comprising from about 0.5 to about 50 mg/kg/day.
Claim 4
Dependent Claim
17 words
The method according to claim 2, wherein said amount comprises from about 1 to about 5 mg/kg/day.
Claim 5
Dependent Claim
24 words
The method according to claim 1, wherein said rapamycin is administered for a period of time comprising from about 1 to about 180 days.
Claim 6
Dependent Claim
12 words
The method according to claim 1, wherein said rapamycin is administered orally.
Claim 7
Dependent Claim
12 words
The method according to claim 1, wherein said rapamycin is administered parenterally.
Claim 8
Dependent Claim
23 words
The method according to claim 1, wherein said rapamycin is administered for an indefinite period of time to maintain inhibition of transparent rejection.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-31 | 1995-09-30 | 1996-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-31 | 1999-09-30 | 2000-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-31 | 2003-09-30 | 2004-03-31 | $7700.00 | Window Closed / Lapsed |