US5554389A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Urinary bladder submucosa derived tissue graft
Assignee: Purdue Research Foundation
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Filing: 1995-04-07
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Granted: 1996-09-10
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Expires: 2015-04-07
Abstract
Abstract A tissue graft composition comprising bladder submucosal tissue delaminated from abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of vertebrate urinary bladder is described. The graft composition can be implanted to replace or support damaged or diseased tissues.
Inventors
- 👤 Stephen F. Badylak
- 👤 Sherry L. Voytik
- 👤 Andrew Brightman
- 👤 Matt Waninger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:32
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61K; A61K35/00; A61K35/12; A61K35/22; A61L27/3604; A61L27/3641; A61L27/3645; A61P; A61P43/00; C; C12; C12N; C12N5/00; C12N5/0068; C12N2533/00; C12N2533/90; C12N2533/92; Y; Y10; Y10S; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
35 words
A composition comprising urinary bladder submucosa delaminated from both the abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm blooded vertebrate.
Claim 2
Dependent Claim
35 words
A composition comprising urinary bladder submucosa delaminated from both the abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm blooded vertebrate.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein the urinary bladder submucosa is fluidized.
Claim 4
Dependent Claim
31 words
The composition of claim 1 wherein the urinary bladder submucosa is digested with a protease for a period of time sufficient to solubilize the tissue and provide a substantially homogenous solution.
Claim 5
Dependent Claim
16 words
The composition of claim 1, wherein the urinary bladder submucosa is dried and in powder form.
Claim 6
Dependent Claim
22 words
The composition of claim 1 formed into a cylinder having a predetermined luminal diameter and sutured along the length of the cylinder.
Claim 7
Dependent Claim
33 words
The composition of claim 1 conditioned for use as a connective tissue substitute by stretching to produce a graft construct longer than the segment of urinary bladder tissue from which it is formed.
Claim 8
Dependent Claim
51 words
A non-immunogenic tissue graft composition capable of inducing endogenous connective tissue growth when implanted in warm-blooded vertebrates, said composition comprising urinary bladder submucosa delaminated from both the abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm-blooded vertebrate.
Claim 9
Dependent Claim
51 words
A non-immunogenic tissue graft composition capable of inducing endogenous connective tissue growth when implanted in warm-blooded vertebrates, said composition comprising urinary bladder submucosa delaminated from both the abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm-blooded vertebrate.
Claim 10
Independent Claim
52 words
A method for inducing the formation of endogenous connective tissue at a site in need of endogenous tissue growth in a warm blooded vertebrate, said method comprising transplanting a graft composition comprising urinary bladder submucosa in an amount effective to induce endogenous connective tissue growth at the site the composition is administered.
Claim 11
Independent Claim
52 words
A method for inducing the formation of endogenous connective tissue at a site in need of endogenous tissue growth in a warm blooded vertebrate, said method comprising transplanting a graft composition comprising urinary bladder submucosa in an amount effective to induce endogenous connective tissue growth at the site the composition is administered.
Claim 12
Dependent Claim
20 words
The method of claim 8, wherein the graft composition is fluidized and is administered by injection into the warm-blooded vertebrate.
Claim 13
Dependent Claim
20 words
The method of claim 8, wherein the graft composition is administered by surgically implanting the composition into the warm-blooded vertebrate.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-09-10 | 2000-03-11 | 2000-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-09-10 | 2004-03-11 | 2004-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-09-10 | 2008-03-11 | 2008-09-10 | $7700.00 | Window Closed / Lapsed |