US5554177A — Method and apparatus to optimize pacing based on …

Claim 1

Independent Claim 131 words

A method for adjusting a cardiac pacemaker by automatically responding to abnormal sounds caused by a suboptimal heart condition comprising; isolating a particular heart sound believed to be indicative of the suboptimal heart condition at least in part by relating it temporally to the time of first (S 1 ) and second (S 2 ) heart sounds from the signal produced by an acoustic sensor adaptively situated in association with the body of a patient to receive such sounds and from them for producing high signal levels of such sounds, determining a measure of at least one characteristic of the particular heart sound, adjusting the time period before the next delivered pacing pulse until the lowest desirable measure of said at least one characteristic of said particular heart sound is detected.

Claim 2

Independent Claim 131 words

A method for adjusting a cardiac pacemaker by automatically responding to abnormal sounds caused by a suboptimal heart condition comprising; isolating a particular heart sound believed to be indicative of the suboptimal heart condition at least in part by relating it temporally to the time of first (S 1 ) and second (S 2 ) heart sounds from the signal produced by an acoustic sensor adaptively situated in association with the body of a patient to receive such sounds and from them for producing high signal levels of such sounds, determining a measure of at least one characteristic of the particular heart sound, adjusting the time period before the next delivered pacing pulse until the lowest desirable measure of said at least one characteristic of said particular heart sound is detected.

Claim 3

Dependent Claim 60 words

A method as set forth in claim 1 wherein said time period adjustment is accomplished by adjusting an AV delay by incrementally changing the pacing pulse timing measured from the atrial sensed depolarization to the delivery of the ventricular pacing pulse such that the lowest desirable measure of said at least one characteristic of said particular heart sound is detected.

Claim 4

Dependent Claim 66 words

A method as set forth in claim 1 wherein said time period adjustment is accomplished by adjusting an AV delay by incrementally changing the pacing pulse timing measured from an atrial paced pulse delivery to the delivery of the ventricular pacing pulse to optimize the AV delay such that the lowest desirable measure of said at least one characteristic of said particular heart sound is detected.

Claim 5

Dependent Claim 57 words

A method as set forth in claim 1 wherein the abnormal heart condition is cardiomyopathy and the particular heart sound is MR, and wherein the time between heart sounds S1 and S2 is the temporal location for searching for said MR sound, and wherein the characteristic is from the set of sound characteristics including volume and duration.

Claim 6

Dependent Claim 40 words

A method as in claim 1 wherein said time period adjustment is accomplished by adjusting said pacing pulse timing until the desired characteristic of said particular heart sound is detected, and then leaving said adjustment to run in said pacemaker.

Claim 7

Dependent Claim 39 words

A method as set forth in claim 1 wherein said time period adjustment is accomplished automatically by a processor making timing adjustments to said pacemaker in accord with a program that seeks the desired characteristic of the heart sound.

Claim 8

Dependent Claim 43 words

A method as in claim 2 wherein said time period adjustment is accomplished by adjusting said pacing pulse timing until the lowest volume of said particular heart sound is detected, and then leaving said adjustment to run in said pacemaker in the patient.

Claim 9

Dependent Claim 46 words

A method as set forth in claim 1 wherein said time period adjustment is accomplished automatically by a processor making timing adjustments to said pacemaker in accord with a program that seeks the lowest volume acoustic feedback for the temporal location of said particular heart sound.

Claim 10

Dependent Claim 30 words

A method as set forth in claim 3 wherein a range is set previous to adjusting the AV delay to optimum such that the optimum is located within said range.

Claim 11

Dependent Claim 73 words

The method as set forth in claim 2 wherein the equation: AV delay.sub.N+1 =AV delay.sub.N (1+a(MRSA.sub.N -MRSA.sub.N-1)) is applied by a processor to adjust the AV delay for each new heart cycle " N+1 ", wherein each N indicates a heart beat cycle, N-1 indicates a heart beat cycle previous to N , MRSA N is the MR sound amplitude for heart cycle N and a is the gain for the system response.

Claim 12

Dependent Claim 73 words

The method as set forth in claim 9 wherein the equation: AV delay.sub.N+1 =AV delay.sub.N (1+a(MRSA.sub.N -MRSA.sub.N-1)) is applied by a processor to adjust the AV delay for each new heart cycle " N+1 ", wherein each N indicates a heart beat cycle, N-1 indicates a heart beat cycle previous to N , MRSA N is the MR sound amplitude for heart cycle N and a is the gain for the system response.

Claim 13

Independent Claim 155 words

An apparatus for adjusting the timing of pacing pulses delivered by an implanted cardiac pacer based on acoustic intensity of a particular heart sound comprising: an acoustic sensor located in association with a patient's body disposed so as to pick up heart sounds as said heart sounds occur in temporal relation to a first (S 1 ) and a second (S 2 ) heart sound in each cardiac cycle and for providing as output an intensity signal related to sensed volume of all sensed said heart sounds, a circuit for determining the intensity of one particular heart sound from the output of said acoustic sensor, a processor for adjusting the delay period between delivered pacing pulses delivered by said cardiac pacemaker adapted to make said adjustments based on the intensity of said one particular heart sound said one particular heart sound is known as Mitral Regurgitation which occurs between said first and second heart sounds.

Claim 14

Independent Claim 155 words

An apparatus for adjusting the timing of pacing pulses delivered by an implanted cardiac pacer based on acoustic intensity of a particular heart sound comprising: an acoustic sensor located in association with a patient's body disposed so as to pick up heart sounds as said heart sounds occur in temporal relation to a first (S 1 ) and a second (S 2 ) heart sound in each cardiac cycle and for providing as output an intensity signal related to sensed volume of all sensed said heart sounds, a circuit for determining the intensity of one particular heart sound from the output of said acoustic sensor, a processor for adjusting the delay period between delivered pacing pulses delivered by said cardiac pacemaker adapted to make said adjustments based on the intensity of said one particular heart sound said one particular heart sound is known as Mitral Regurgitation which occurs between said first and second heart sounds.

Claim 15

Dependent Claim 29 words

An apparatus as set forth in claim 12 wherein said processor for adjusting the delay adjusts said delay so as to decrease the intensity of said one particular sound.

Claim 16

Dependent Claim 122 words

An apparatus as set forth in claim 12 wherein said processor employs the equation: delay.sub.N+1 =delay.sub.N (1+a(SA.sub.N -SA.sub.N-1)) to adjust the pulse timing delay for each new heart cycle " N+1 ", wherein each N indicates a heart beat cycle, N-1 indicates a heart beat cycle previous to N , SA N is the one particular heart sound amplitude for heart cycle N and a is the gain for the system response, such that each value determined for the variable delay N+1 affects an AV delay value kept by a memory in the apparatus, which AV delay will be used to set the timing of the next ventricular pacing pulse to be delivered by said apparatus, timed from a last atrial event.

Claim 17

Dependent Claim 121 words

An apparatus as set forth in claim 13 wherein said processor employs the equation: AV delay.sub.N+1 =AV delay.sub.N (1+a(MRSA.sub.N -MRSA.sub.N-1)) to adjust the AV delay for each new heart cycle " N+1 ", wherein each N indicates a heart beat cycle, N-1 indicates a heart beat cycle previous to N , MRSA N is the MR sound amplitude for heart cycle N and a is the gain for the system response, such that each value determined for the variable delay N+1 affects an AV delay value kept by a memory in the apparatus, which AV delay will be used to set the timing of the next ventricular pacing pulse to be delivered by said apparatus, timed from a last atrial event.

Claim 18

Dependent Claim 23 words

An apparatus as set forth in claim 12 wherein said processor adjusts the delay period but only within a predetermined range of time.

Claim 19

Dependent Claim 53 words

An apparatus as set forth in claim 16 wherein said processor makes adjustments to said delay period in small increments in the direction of the middle of said range and beyond it until a minimum abnormal cardiac sound is produced, then back in the opposite direction iteratively until a final minimum is found.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1999-09-10	2000-03-11	2000-09-10	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2003-09-10	2004-03-11	2004-09-10	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2007-09-10	2008-03-11	2008-09-10	$7700.00	Window Closed / Lapsed

Method and apparatus to optimize pacing based on intensity of acoustic signal

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