US5552452A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Organic tissue glue for closure of wounds
Assignee: Arch Development Corp
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Filing: 1993-03-15
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Granted: 1996-09-03
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Expires: 2013-03-15
Abstract
Abstract The present invention relates generally to the field of biological and medical adhesives and encompasses more specifically the closing of microsurgical wounds and other tissue wounds and defects due to surgical procedures or other causes. A medical adhesive comprising a photosensitizing species and an protein or peptide containing moiety are disclosed which may be applied to various tissues, an adhesive bond being formed by exposure of the adhesive to photoactivating radiation.
Inventors
- 👤 John Khadem
- 👤 Toan V. Truong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:04
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; Y; Y10; Y10S; Y10S522/00; Y10S522/904
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
53 words
A composition comprising from about 1% (w/v) to about 50% (w/v) of a biocompatible peptide in solution and in combination with an amount of a flavin photosensitizer capable of producing reactive oxygen species and effective to promote the formation of an adhesive upon photoactivation without more than about 2° C. rise in temperature.
Claim 2
Dependent Claim
53 words
A composition comprising from about 1% (w/v) to about 50% (w/v) of a biocompatible peptide in solution and in combination with an amount of a flavin photosensitizer capable of producing reactive oxygen species and effective to promote the formation of an adhesive upon photoactivation without more than about 2° C. rise in temperature.
Claim 3
Dependent Claim
10 words
The composition of claim 1, wherein the photosensitizer is riboflavin-5-phosphate.
Claim 4
Dependent Claim
13 words
The composition of claim 1, wherein the photosensitizer is attached to the peptide.
Claim 5
Dependent Claim
12 words
The composition of claim 1, further defined as comprising a biocompatible protein.
Claim 6
Dependent Claim
12 words
The composition of claim 4, further defined as comprising an autologous protein.
Claim 7
Dependent Claim
21 words
The composition of claim 4, further defined as comprising a connective tissue protein, a plasma protein or a clotting cascade protein.
Claim 8
Dependent Claim
22 words
The composition of claim 6, further defined as comprising one or more of collagen, keratin, elastin, hyaluronic acid, albumin, myoglobin or fibrinogen.
Claim 9
Dependent Claim
12 words
The composition of claim 4, further defined as comprising crystallin lens protein.
Claim 10
Dependent Claim
10 words
The composition of claim 4, further defined as comprising fibrinogen.
Claim 11
Dependent Claim
11 words
The composition of claim 9, wherein the fibrinogen is autologous fibrinogen.
Claim 12
Dependent Claim
13 words
The composition of claim 9, wherein the fibrinogen is an 18% fibrinogen formulation.
Claim 13
Dependent Claim
17 words
The composition of claim 1, further defined as comprising an 18% fibrinogen formulation in combination with riboflavin-5-phosphate.
Claim 14
Dependent Claim
17 words
The composition of claim 1, wherein the peptide and the photosensitizer are combined within a single composition.
Claim 15
Dependent Claim
14 words
The composition of claim 1, wherein the peptide and the photosensitizer are separate compositions.
Claim 16
Dependent Claim
62 words
A composition comprising from about 1% (w/v) to about 50% (w/v) of a biocompatible peptide in solution and in combination with an amount of a flavin photosensitizer capable of producing reactive oxygen species and effective to promote the formation of an adhesive upon photoactivation without more than about 2° C. rise in temperature, the combination intended for use as a tissue adhesive.
Claim 17
Dependent Claim
62 words
A composition comprising from about 1% (w/v) to about 50% (w/v) of a biocompatible peptide in solution and in combination with an amount of a flavin photosensitizer capable of producing reactive oxygen species and effective to promote the formation of an adhesive upon photoactivation without more than about 2° C. rise in temperature, the combination intended for use as a tissue adhesive.
Claim 18
Dependent Claim
26 words
The composition of claim 15, wherein the peptide is present within a selected tissue and wherein said composition is intended for application to the selected tissue.
Claim 19
Dependent Claim
24 words
The composition of claim 16, wherein the peptide composition comprises crystallin lens protein and wherein said composition is intended for application to the eye.
Claim 20
Dependent Claim
67 words
A method of using the composition of claim 1 for forming an adhesive connection between tissues, comprising: (a) providing a composition in accordance with claim 1; (b) applying the composition to the tissues to be connected to form a tissue adhesive combination; and (c) applying electromagnetic energy to the tissue adhesive combination in a manner effective to promote the formation of an adhesive connection between the tissues.
Claim 21
Dependent Claim
22 words
The method of claim 18, wherein the electromagnetic energy applied has a wavelength of between about 10 nm and about 670 nm.
Claim 22
Dependent Claim
16 words
The method of claim 18, wherein the electromagnetic energy is in the form of optical energy.
Claim 23
Dependent Claim
18 words
The method of claim 18, wherein the electromagnetic energy is in the form of a monochromatic laser beam.
Claim 24
Dependent Claim
29 words
The method of claim 21, wherein the laser beam is generated by an argon laser, a krypton laser, a tunable dye laser, an excimer laser or a diode laser.
Claim 25
Dependent Claim
18 words
The method of claim 18, wherein the electromagnetic energy is in the form of a polychromatic energy beam.
Claim 26
Dependent Claim
22 words
The method of claim 23, wherein the polychromatic energy beam is generated by a incandescent, fluorescent, xenon or mercury vapor light source.
Claim 27
Dependent Claim
20 words
The method of claim 18, wherein the electromagnetic radiation is applied for between about 1 second and about 4 minutes.
Claim 28
Dependent Claim
14 words
The method of claim 25, wherein the composition comprises fibrinogen or crystallin lens protein.
Claim 29
Dependent Claim
13 words
The method of claim 18, wherein the tissue is located within an animal.
Claim 30
Dependent Claim
12 words
The method of claim 27, wherein the animal is a human subject.
Claim 31
Dependent Claim
20 words
The method of claim 18, wherein the composition comprises a protein or peptide present within the tissue to be connected.
Claim 32
Dependent Claim
14 words
The method of claim 18, wherein the composition is applied as a single composition.
Claim 33
Dependent Claim
13 words
The method of claim 18, wherein the composition is applied as separate compositions.
Claim 34
Dependent Claim
10 words
The method of claim 18, wherein the composition comprises fibrinogen.
Claim 35
Dependent Claim
10 words
The method of claim 18, wherein the composition comprises riboflavin-5-phosphate.
Claim 36
Dependent Claim
17 words
The method of claim 33, wherein the composition comprises an 18% fibrinogen formulation in combination with riboflavin-5-phosphate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-09-03 | 2000-03-04 | 2000-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-09-03 | 2004-03-04 | 2004-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-09-03 | 2008-03-04 | 2008-09-03 | $7700.00 | Window Closed / Lapsed |