EP0305026A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Transdermal drug delivery device with dual permeation enhancers
Assignee: Alza Corp
•
Filing: 1988-03-31
•
Granted: —
•
Expires: 2008-03-31
Abstract
Abstract A dosage form that coadministers a drug and two percutaneous absorption enhancers to a defined area of the skin is described. The dosage form comprises a body that contains supplies of drug and enhancers and has a basal surface that contacts the area of skin and transmits the drug and enhancers to the area for absorption thereby.
Inventors
- 👤 Harold F. Sanders
- 👤 David J. Enscore
- 👤 Yu-Ling Cheng
- 👤 Shari B. Libicki
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 11:34
CPC Classifications
A; A61; A61M; A61M37/00; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/14; A61K9/0012; A61K9/0014; C; C08; C08L; C08L29/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
143 words
A unit dosage form for transdermally coadministering a drug, and permeation enhancers ethanol and glycerol monolaurate, to a predetermined area of unbroken skin of a patient for a predetermined time period, the dosage form comprising a body: having a basal surface of area at least about equal to the area of skin, that is adapted to contact the area of skin over said time period, and via which the drug, and the permeation enhancers ethanol and glycerol monolaurate, are presented to the area of skin for absorption thereby; containing a supply of the drug that communicates with the basal surface to provide drug at the basal surface over said time period; containing a supply of ethanol that communicates with the basal surface over said time period; and containing a supply of glycerol monolaurate that communicates with the basal surface over said time period.
Claim 2
Dependent Claim
143 words
A unit dosage form for transdermally coadministering a drug, and permeation enhancers ethanol and glycerol monolaurate, to a predetermined area of unbroken skin of a patient for a predetermined time period, the dosage form comprising a body: having a basal surface of area at least about equal to the area of skin, that is adapted to contact the area of skin over said time period, and via which the drug, and the permeation enhancers ethanol and glycerol monolaurate, are presented to the area of skin for absorption thereby; containing a supply of the drug that communicates with the basal surface to provide drug at the basal surface over said time period; containing a supply of ethanol that communicates with the basal surface over said time period; and containing a supply of glycerol monolaurate that communicates with the basal surface over said time period.
Claim 3
Dependent Claim
46 words
The unit dosage form as claimed in claim 1 wherein said supply of drug provides drug such that over a substantial portion of said time period, the amount of drug provided is in excess of that which the area of the skin is able to absorb.
Claim 4
Dependent Claim
44 words
The unit dosage form as claimed in claim 1 or claim 2 which further comprises: a means for maintaining the rate at which at least one permeation enhancer is provided at the basal surface substantially constant over a substantial portion of the time period.
Claim 5
Dependent Claim
62 words
The unit dosage form of claim 3 wherein said means maintains the rate at which at least one enhancer is provided to the basal surface such that said rate is below the maximum rate the skin is able to absorb, and sufficient in combination with the other permeation enhancer to substantially increase the permeability of the area of skin to the drug.
Claim 6
Dependent Claim
24 words
The unit dosage form as claimed in claim 4 wherein said means maintains the rate at which ethanol is provided to the basal surface.
Claim 7
Dependent Claim
21 words
The unit dosage form as claimed in any preceding claim wherein the basal surface is adhesive to the area of skin.
Claim 8
Dependent Claim
27 words
The unit dosage form as claimed in any preceding claim wherein the supplies of drug, ethanol and glycerol monolaurate are admixed and contained within the same reservoir.
Claim 9
Dependent Claim
28 words
The unit dosage form as claimed in any preceding claim wherein the supply of drug and the supplies of ethanol and glycerol monolaurate are maintained in separate reservoirs.
Claim 10
Dependent Claim
45 words
The unit dosage form as claimed in any preceding claim wherein the means is a rate controlling membrane positioned between the supplies of ethanol and glycerol monolaurate and the basal surface through which the ethanol and glycerol monolaurate must permeate to reach the basal surface.
Claim 11
Dependent Claim
58 words
The unit dosage form as claimed in any preceding claim wherein the rates at which ethanol and glycerol monolaurate are provided at the basal surface are above that rate at which the rate of absorption of the drug by the area of skin ceases to increase significantly as the rates at which the enhancers are provided, are increased.
Claim 12
Dependent Claim
15 words
The unit dosage form as claimed in any preceding claim wherein said drug is nilvadipine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.