Patent US5451406A successfully refreshed from Google Patents.
US5451406A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue injectable composition and method of use
Assignee: Carbon Medical Technologies Inc
•
Filing: 1994-07-14
•
Granted: 1995-09-19
•
Expires: 2014-07-14
Abstract
Abstract An improved biocompatible composition consisting of physiologically stable microparticles carried in a lubricative suspension, solution, other fluid or gel is presented. The composition is intended to be delivered into the body through a small-bore needle, cannula, or catheter and to a tissue site for the purpose of augmenting the tissue site and surrounding area, thereby correcting a defect, filling a void, or strengthening the support structures of the tissue. The particles are a hard, metallic substance and are carbon-coated.
Inventors
- 👤 Timothy P. Lawin
- 👤 Jeffrey M. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:47
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/0059; A61F2/0004; A61F2/0031; A61F2/0036; A61F2/02; A61F2/04; A61F2/042; A61L; A61L27/00; A61L27/02; A61L27/04; A61L27/28; A61L27/30; A61L27/303; A61L27/40; A61L27/44; A61L27/446; A61L27/50; A61F2310/00; A61F2310/00389; A61F2310/00574; A61L2400/00; A61L2400/06
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
59 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles in a carrier, wherein the particles are substrate particles with a carbon coating and have an average, transverse cross-sectional dimension of between 100 and 1,000 microns and the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, and has lubricative qualities.
Claim 2
Dependent Claim
59 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles in a carrier, wherein the particles are substrate particles with a carbon coating and have an average, transverse cross-sectional dimension of between 100 and 1,000 microns and the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, and has lubricative qualities.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein: said substrate particles are a metallic substance.
Claim 4
Dependent Claim
24 words
The composition of claim 1 wherein: the substrate particles are selected from the group comprising stainless steel, titanium and titanium alloys, and their oxides.
Claim 5
Dependent Claim
12 words
The composition of claim 1 wherein: said carbon coating is isotropic carbon.
Claim 6
Dependent Claim
12 words
The composition of claim 1 wherein: said substrate particles are zirconium oxide.
Claim 7
Dependent Claim
17 words
The composition of claim 4 wherein: said isotropic carbon coating is low temperature isotropic (LTI), pyrolyric carbon.
Claim 8
Dependent Claim
12 words
The composition of claim 6 wherein: said substrate particles are zirconium oxide.
Claim 9
Dependent Claim
20 words
The composition of claim 4 wherein: said isotropic carbon coating is ultra low temperature isotropic carbon which is vapor deposited.
Claim 10
Dependent Claim
13 words
The composition of claim 1 wherein: said carbon coating is pyrolyric, isotropic carbon.
Claim 11
Dependent Claim
13 words
The composition of claim 8 wherein: said substrate particles are gold or silver.
Claim 12
Dependent Claim
14 words
The composition of claim 1 wherein: said carbon coating is a smooth, surface film.
Claim 13
Dependent Claim
13 words
The composition of claim 4 wherein: said coating is a smooth, surface film.
Claim 14
Dependent Claim
12 words
The composition of claim 4 wherein: said carbon coating is vitreous carbon.
Claim 15
Dependent Claim
12 words
The composition of claim 11 wherein: said substrate particles are zirconium oxide.
Claim 16
Dependent Claim
23 words
The composition of claim 4 wherein: said substrate particles are of rounded shape and said dimension is between 200 microns and 500 microns.
Claim 17
Dependent Claim
11 words
The composition of claim 1 wherein: the substrate particles are radiopaque.
Claim 18
Dependent Claim
16 words
The composition of claim 1 wherein: the carrier is a solution, suspension or gel of polysaccharides.
Claim 19
Dependent Claim
10 words
The composition of claim 17 wherein: the polysaccharide is beta-glucan.
Claim 20
Dependent Claim
53 words
The composition of claim 1 wherein: the carrier is a solution or suspension selected from the group comprised of hyaluronic acid, polyvinyl pyrrolidone or a hydrogel derivative thereof, dextran or a hydrogel derivative thereof, glycerol, polyethylene glycol, succinylated collagen, liquid collagen, or other polysaccharides or biocompatible organic polymers, either singly or in combination.
Claim 21
Independent Claim
57 words
A method for augmenting tissue in a human patient comprising injecting into a tissue site in the patient a composition comprising a plurality of discrete, carbon coated substrate particles having an average, transverse, cross-sectional dimension of between 100 and 1,000 microns in a biocompatible carrier having sufficient fluidity to carry and deliver the particles and lubricative qualities.
Claim 22
Independent Claim
57 words
A method for augmenting tissue in a human patient comprising injecting into a tissue site in the patient a composition comprising a plurality of discrete, carbon coated substrate particles having an average, transverse, cross-sectional dimension of between 100 and 1,000 microns in a biocompatible carrier having sufficient fluidity to carry and deliver the particles and lubricative qualities.
Claim 23
Dependent Claim
14 words
The method of claim 20 wherein the tissue site is in the urinary tract.
Claim 24
Dependent Claim
14 words
The method of claim 21 wherein the tissue site is the urinary sphincter muscle.
Claim 25
Dependent Claim
12 words
The method of claim 21 wherein the tissue site is the urethra.
References Cited (Backward Citations)
US3783868A
Cited
US3977896A
Cited
US4803075A
Cited
US4773393A
Cited
US5258028A
Cited
US5007940A
Cited
US5116387A
Cited
US5158573A
Cited
US5204382A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-09-18 | 1999-03-20 | 1999-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-09-18 | 2003-03-20 | 2003-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-09-18 | 2007-03-20 | 2007-09-19 | $7700.00 | Window Closed / Lapsed |