Patent US5405309A successfully refreshed from Google Patents.
US5405309A
Expired / Lapsed
US
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X-ray emitting interstitial implants
Assignee: Theragenics Corp
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Filing: 1993-04-28
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Granted: 1995-04-11
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Expires: 2013-04-28
Abstract
Abstract Safe, isotopically pure Pd-103-containing seeds of high apparent activity are formed by bombarding an Rh target in a cyclotron with high energy particles to obtain Rh containing carrier-free Pd-103, separating therefrom the carrier-free Pd-103, adding a small amount of Pd to the carrier-free Pd-103, electroplating said Pd-103/Pd admixture to a pellet(s) of electroconductive material and encapsulating the pellet(s) within a bicompatible container or shell.
Inventors
- 👤 John L. Carden, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:36
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1027; A61N2005/1019; A61N2005/1024
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
107 words
A seed for implantation into a tumor within a living body to emit X-ray radiation thereto comprising at least one pellet of an electroconductive support substantially non-absorbing of X-rays, having electroplated thereon a layer of a palladium composition consisting of carrier-free palladium 103 having added thereto palladium metal in an amount sufficient to promote said electroplating, said at least one electroplated pellet containing Pd-103 in an amount sufficient to provide a radiation level measured as apparent mCi of greater than 0.5, and a shell of a bicompatible material encapsulating said at least one electroplated pellet, said biocompatible material being penetrable by X-rays in the 20-23 kev range.
Claim 2
Dependent Claim
107 words
A seed for implantation into a tumor within a living body to emit X-ray radiation thereto comprising at least one pellet of an electroconductive support substantially non-absorbing of X-rays, having electroplated thereon a layer of a palladium composition consisting of carrier-free palladium 103 having added thereto palladium metal in an amount sufficient to promote said electroplating, said at least one electroplated pellet containing Pd-103 in an amount sufficient to provide a radiation level measured as apparent mCi of greater than 0.5, and a shell of a bicompatible material encapsulating said at least one electroplated pellet, said biocompatible material being penetrable by X-rays in the 20-23 kev range.
Claim 3
Dependent Claim
13 words
An implantable seed according to claim 1 wherein the electroconductive support comprises graphite.
Claim 4
Dependent Claim
30 words
An implantable seed according to claim 1 wherein said seed includes an X-ray opaque marker with said shell for external visualization of said pellet after its implantation in the body.
Claim 5
Dependent Claim
25 words
An implantable seed according to claim 3 wherein the material forming said X-ray-opaque marker is selected from the group consisting of lead, rhodium and palladium.
Claim 6
Dependent Claim
53 words
An implantable seed according to claim 3 wherein said shell has a generally tubular configuration, said marker is generally centrally located, and said at least one pellet includes two pellets, with one pellet disposed on either side of said marker to help promote a generally isotropic distribution of X-rays emitted from said particle.
Claim 7
Dependent Claim
39 words
A seed according to claim 1 wherein the palladium composition possesses a radioisotopic purity such that the dose from other isotopes is less than 1% of that from said Pd-103 and a specific activity of at least 2.5 Ci/g.
Claim 8
Dependent Claim
13 words
A seed according to claim 1 wherein the shell is made of titanium.
Claim 9
Independent Claim
171 words
A method of preparing a safe seed for implantation into a tumor within a living body to emit x-ray radiation said seed having a predetermined radiation level measured as apparent mCi comprising irradiating and Rh metal target in a charged particle accelerator under conditions that produce carrier-free Pd-103 in said Rh metal, recovering carrier-free Pd-103 from Rh metal, forming a carrier-free Pd-103/palladium admixture by adding palladium metal to said carrier-free Pd-103 in a small amount sufficient to promote electroplating of said mixture and to adjust its specific activity, removing, if necessary, non-palladium isotopes from said admixture, electroplating a layer of said palladium 103/palladium admixture having a known specific activity and self absorption onto at least one pellet of an electroconductive material substantially non-absorbing of X-rays, the amount of Pd-103 in said layer being sufficient to provide a radiation level measured as apparent mCi of greater than 0.5, and encapsulating said at least one pellet within a shell of a bicompatible material that is penetrable by X-rays in the 20-23 kev range.
Claim 10
Independent Claim
171 words
A method of preparing a safe seed for implantation into a tumor within a living body to emit x-ray radiation said seed having a predetermined radiation level measured as apparent mCi comprising irradiating and Rh metal target in a charged particle accelerator under conditions that produce carrier-free Pd-103 in said Rh metal, recovering carrier-free Pd-103 from Rh metal, forming a carrier-free Pd-103/palladium admixture by adding palladium metal to said carrier-free Pd-103 in a small amount sufficient to promote electroplating of said mixture and to adjust its specific activity, removing, if necessary, non-palladium isotopes from said admixture, electroplating a layer of said palladium 103/palladium admixture having a known specific activity and self absorption onto at least one pellet of an electroconductive material substantially non-absorbing of X-rays, the amount of Pd-103 in said layer being sufficient to provide a radiation level measured as apparent mCi of greater than 0.5, and encapsulating said at least one pellet within a shell of a bicompatible material that is penetrable by X-rays in the 20-23 kev range.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-04-10 | 1998-10-10 | 1999-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-10 | 2002-10-10 | 2003-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-10 | 2006-10-10 | 2007-04-11 | $7700.00 | Window Closed / Lapsed |